Influence of intestinal bacterial decontamination using metronidazole and ciprofloxacin or ciprofloxacin alone on the development of acute graft- versus-host disease after marrow transplantation in patients with hematologic malignancies: Final results and long-term follow-up of an open-label prospective randomized trial

Blood

Volumn 93, Issue 10, 1999, Pages 3267-3275

  Beelen, Dietrich W ^a   Elmaagacli, Ahmet ^a   Müller, Karl Dieter ^a   Hirche, Herbert ^a   Schaefer, Ulrich W ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; BUSULFAN; CIPROFLOXACIN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; METHOTREXATE; METRONIDAZOLE;

ADOLESCENT; ADULT; ANTIBIOTIC THERAPY; ARTICLE; BACTERICIDAL ACTIVITY; BONE MARROW TRANSPLANTATION; CARDIOTOXICITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; GRAFT VERSUS HOST REACTION; HLA SYSTEM; HUMAN; INCIDENCE; INTERSTITIAL PNEUMONIA; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; NEPHROTOXICITY; NEUTROPENIA; ORAL DRUG ADMINISTRATION; ORGAN DONOR; PATHOGENESIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE; TREATMENT INDICATION; TREATMENT OUTCOME;

EID: 0033562823     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.10.3267.410k22_3267_3275     Document Type: Article

References (37)

1. Storb R, Deeg HJ, Whitehead J, Appelbaum F, Beatty P, Bensinger W, Buckner CD, Clift R, Doney K, Farewell V, Hansen J, Hill R, Lum L, Martin P, McGuffin R, Sanders J, Stewart P, Sullivan K, Witherspoon R, Yee G, Thomas ED: Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft-versus-host disease after marrow transplantation for leukemia. N Engl J Med 314:729, 1986
2. Storb R, Deeg HJ, Pepe M, Appelbaum F, Anasetti C, Beatty P, Bensinger W, Berenson R, Buckner CD, Clift R, Doney K, Longton G, Hansen J, Hill R, Loughran T, Martin P, Singer J, Sanders J, Stewart P, Sullivan K, Witherspoon R, Thomas ED: Methotrexate and cyclosporine versus cyclosporine alone for prophylaxis of acute graft-versus-host disease in patients given HLA-identical marrow grafts for leukemia: Long-term follow-up of a controlled trial. Blood 73:1729, 1989
3. Atkinson K, Farrell C, Chapman G, Downs K, Penny R, Biggs J: Female marrow donors increase the risk of acute graft-versus-host disease: Effect of donor age and parity and analysis of cell subpopulations in the donor inoculum. Br J Haematol 63:231, 1986
4. Gale RP, Bortin MM, van Bekkum DW, Biggs JC, Dicke KA, Gluckman E, Good RA, Hoffmann RG, Kay HEM, Kersey JH, Marmont A, Masaoka T, Rimm A, van Rood JJ, Zwaan FE: Risk factors for acute graft-versus-host disease. Br J Haematol 67:397, 1987
5. Hill GR, Krengler W, Ferrara JM: The role of cytokines in acute graft-versus-host disease. Cytokines Cell Mol Ther 3:257, 1997
6. Jones JM, Wilson R, Bealmear PM: Mortality and gross pathology of secondary disease in germ free mouse radiation chimeras. Radiat Res 45:577, 1971
7. van Bekkum DW, Roodenburg J, Heidt PJ, van der Waaij D: Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora. J Natl Cancer Inst 52:401, 1974
8. Heit H, Wilson R, Fliedner TM, Kohne E: Mortality of secondary disease in antibiotic treated mouse radiation chimeras, in Heneghan JB (ed): Germfree Research: Biological Effects of Gnotobiotic Environments. New York, NY, Academic, 1973, p 477
9. Wagemaker G, Heidt PJ, Merchav S, van Bekkum DW: Abrogation of histocompatibility barriers to bone marrow transplantation in rhesus monkeys, in Baum SD, Ledney GD, Thierfelder S (eds): Experimental Hematology Today. Basel, Switzerland, Karger, 1982, p 111
10. Heidt PI: Gnotobiotics and Bone Marrow Transplantation: Experimental and Clinical Studies. Rijswijk, The Netherlands, Radiobiological Institute of the Division for Health Research TNO, 1989, p 21
11. Van Bekkum DW, Knaan S: Role of bacterial flora in development of intestinal lesions from graft-versus-host reaction. J Natl Cancer Inst 58:787, 1977
12. Buckner CD, Clift RA, Sanders JE, Meyers ID, Counts GW, Farewell VT, Thomas ED, and the Seattle Marrow Transplant Team: Protective environment for marrow transplant recipients. A prospective study. Ann Intern Med 89:893, 1978
13. SkinhØj P, Jacobsen N, Hoiby N, Faber V, and the Copenhagen Bone Marrow Transplant Group: Strict protective isolation in allogeneic bone marrow transplantation: Effects on infectious complications, fever and graft versus host disease. Scand J Infect Dis 19:91, 1987
14. Storb R, Prentice RL, Buckner CD, Clift RA, Appelbaum F, Deeg J, Doney K, Hansen JA, Mason M, Sanders J, Singer J, Sullivan KM, Witherspoon RP, Thomas ED: Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environment. N Engl J Med 308:302, 1983
15. Vossen JM, Heidt PI, van den Berg H, Gerritsen EJA, Hermans J, Dooren LJ: Prevention of infection and graft-versus-host disease by suppression of intestinal microflora in children treated with allogeneic bone marrow transplantation. Eur J Clin Microbiol Infect Dis 9:14, 1990
16. Beelen DW, Haralambie E, Brandt H, Linzenmeier G, Müller K-D, Quabeck K, Sayer HG, Graeven U, Mahmoud HK, Schaefer UW: Evidence that sustained growth suppression of intestinal anaerobic bacteria reduces the risk of acute graft-versus-host disease after sibling marrow transplantation. Blood 80:2668, 1992
17. Ottinger HD, Albert E, Arnold R, Beelen DW, Blasczyk R, Bunjes D, Burdach S, Ebell W, Ehninger G, Einsele H, Enczmann J, Fauser A, Friedrich W, Finke J, Göbel U, Goldmann SF, Gramatzki M, Helbig W, Kanz L, Klingebiel T, Kolb HJ, Kühnl P, Löliger C, Müller CR, Müller CA, Niethammer D, Schaefer UW, Sayer H, Schmitz N, Schulze-Rath R, Waßmuth R, Wernet P, Westphal E, Zander R, Zintl F, Grosse-Wilde H: German consensus on immunogenetic donor search for transplantation of allogeneic bone marrow and peripheral blood stem cells. Bone Marrow Transplant 20:101, 1997
18. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457, 1958
19. Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163, 1966
20. Cox DR: Regression models and life-tables. J R Stat Soc 34:187, 1972
21. Kalbfleisch JD, Prentice RL: The Statistical Analysis of Failure Time Data. New York, NY, Wiley, 1980
22. Cole JWL, Grizzle JE: Applications of multivariate analysis of variance to repeated measures experiments. Biometrics 22:810, 1966
23. Haralambie E: Clinically applied gnotobiotics with special regards to anaerobic bacteria, in Ducluzeau R (ed): Gnotobiology and its Applications. Proceedings of the IX International Symposium on Gnotobiology, Lyon, France, Editon Foundation Marcel Merieux, 1980, p 175
24. WHO Handbook for Reporting Results of Cancer Treatment. Geneva, Switzerland, WHO Offset Publications, No. 48, 1979
25. Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, Lerner KG, Thomas ED: Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation 18:295, 1974
26. Thomas ED, Storb R, Clift RA, Fefer A, Johnson FL, Neiman PE, Lerner KG, Glucksberg H, Buckner CD: Bone marrow transplantation (second of two parts). N Engl J Med 292:895, 1975
27. Hill GR, Crawford JM, Cooke KR, Brinson YS, Pan L, Ferrara JLM: Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines. Blood 90:3204, 1997
28. Hallahan DE, Spriggs DR, Beckett MA, Kufe DW, Weichselbaum RR: Increased tumor necrosis factor-a mRNA after cellular exposure to ionizing radiation. Proc Natl Acad Sci USA 86:10104, 1989
29. Sherman ML, Datta R, Hallahan DE, Weichselbaum RR, Kufe DW: Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes. J Clin Invest 87:1794, 1991
30. Piguet PF, Grau GE, Allet B, Vassalli P: Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-versus-host disease. J Exp Med 166:1280, 1987
31. Wang JH, Redmond HP, Watson RW, Bouchier-Hayes D: Role of lipopolysaccharide and tumor necrosis factor-alpha in induction of hepatocyte necrosis. Am J Physiol 269 (2 Pt 1):G297, 1995
32. Remick DG: Lung and gut injury induced by tumour necrosis factor. Res Immunol 144:326, 1993
33. Hattori K, Hirano T, Miyajima H, Yamakawa N, Tateno M, Oshimi K, Kayagaki N, Yagita H, Okumura K: Differential effects of anti-fas ligand and anti-tumor necrosis factor antibodies on acute graft-versus-host disease pathologies. Blood 91:4051, 1998
34. Heinzelmann M, Mercer-Jones MA, Gardner SA, Wilson MA, Polk HC: Bacterial cell wall products increase monocyte HLA-DR and ICAM-1 without affecting lymphocyte CD18 expression. Cell Immunol 176:127, 1997
35. Mattern T, Flad HD, Brade L, Rietschel ET, Ulmer AJ: Stimulation of human T lymphocytes by LPS is MHC unrestricted, but strongly dependent on B7 interactions. J Immunol 160:3412, 1998
36. Eissner G, Kohlhuber F, Grell M, Ueffing M, Scheurich P, Hieke A, Multhoff G, Bornkamm GW, Holler E: Critical involvement of transmembrane tumor necrosis factor-α in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin. Blood 86:4184, 1995 (abstr)
37. Atkinson K, Horowitz MM, Gale RP, van Bekkum DW, Gluckman E, Good RA, Jacobsen N, Kolb HJ, Rimm AA, Ringden O, Rozman C, Sobocinski KA, Zwaan FE, Bortin MM: Risk factors for chronic graft-versus-host disease after HLA-identical sibling bone marrow transplantation. Blood 75:2459, 1990