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Volumn 162, Issue 10, 1999, Pages 6029-6039

Evidence that the Igκ gene MAR regulates the probability of premature V-J joining and somatic hypermutation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; DNA; IMMUNOGLOBULIN J CHAIN; IMMUNOGLOBULIN KAPPA CHAIN; MESSENGER RNA;

EID: 0033561793     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (33)

References (70)
  • 1
    • 0001308351 scopus 로고
    • Chromosomal loop organization in eukaryotic genomes
    • F. Eckstein and D. M. J. Lilley, eds. Springer-Verlag, Berlin
    • Garrard, W. T. 1990. Chromosomal loop organization in eukaryotic genomes. In Nucleic Acids and Molecular Biology, Vol. 4. F. Eckstein and D. M. J. Lilley, eds. Springer-Verlag, Berlin, p. 163.
    • (1990) Nucleic Acids and Molecular Biology , vol.4 , pp. 163
    • Garrard, W.T.1
  • 4
    • 0029791261 scopus 로고    scopus 로고
    • Functional compartmentalization of the nucleus
    • Strouboulis, J., and A. P. Wolffe. 1996. Functional compartmentalization of the nucleus. J. Cell Sci. 109:1991.
    • (1996) J. Cell Sci. , vol.109 , pp. 1991
    • Strouboulis, J.1    Wolffe, A.P.2
  • 5
    • 0022553738 scopus 로고
    • Chromosomal loop anchorage of the K immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites
    • Cockerill, P. N., and W. T. Garrard. 1986. Chromosomal loop anchorage of the K immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites. Cell 44:273.
    • (1986) Cell , vol.44 , pp. 273
    • Cockerill, P.N.1    Garrard, W.T.2
  • 6
    • 0023050122 scopus 로고
    • Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster
    • Gasser, S. M., and U. K. Laemmli. 1986. Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster. Cell 46:521.
    • (1986) Cell , vol.46 , pp. 521
    • Gasser, S.M.1    Laemmli, U.K.2
  • 7
    • 0026842288 scopus 로고
    • Scaffold-associated regions: Cis-acting determinants of chromatin structural loops and functional domains
    • Laemmli, U., E. Kas, L. Poljak, and Y. Adachi. 1992. Scaffold-associated regions: cis-acting determinants of chromatin structural loops and functional domains. Curr. Biol. 2:275.
    • (1992) Curr. Biol. , vol.2 , pp. 275
    • Laemmli, U.1    Kas, E.2    Poljak, L.3    Adachi, Y.4
  • 8
    • 0029918905 scopus 로고    scopus 로고
    • Purification and molecular cloning of the scaffold attachment factor B (SAF-B), a novel human nuclear protein that specifically binds to S/MAR-DNA
    • Renz, A., and F. O. Fackelmayer. 1996. Purification and molecular cloning of the scaffold attachment factor B (SAF-B), a novel human nuclear protein that specifically binds to S/MAR-DNA. Nucleic Acids Res. 24:843.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 843
    • Renz, A.1    Fackelmayer, F.O.2
  • 9
    • 0344413285 scopus 로고
    • Dysfunction of chromosomal loop attachment sites: Illegitimate recombination linked to matrix association regions and topoisomerase II
    • Sperry, A. O., V. C. Blasquez, and W. T. Garrard. 1989. Dysfunction of chromosomal loop attachment sites: illegitimate recombination linked to matrix association regions and topoisomerase II. Proc. Natl. Acad. Sci. USA 86:5497.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 5497
    • Sperry, A.O.1    Blasquez, V.C.2    Garrard, W.T.3
  • 10
    • 0024826968 scopus 로고
    • Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions
    • Adachi, Y., E. Kas, and U. Laemmli. 1989. Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions. EMBO J. 8:3997.
    • (1989) EMBO J. , vol.8 , pp. 3997
    • Adachi, Y.1    Kas, E.2    Laemmli, U.3
  • 11
    • 0026674283 scopus 로고
    • Nucleotide sequence of the intron of the germline human κ immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer
    • Whitehurst, C., H. R. Henney, E. E. Max, H. W. Schroeder Jr., F. Stuber, K. A. Siminovitch, and W. T. Garrard. 1992. Nucleotide sequence of the intron of the germline human κ immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer. Nucleic Acids Res. 20:4929.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 4929
    • Whitehurst, C.1    Henney, H.R.2    Max, E.E.3    Schroeder H.W., Jr.4    Stuber, F.5    Siminovitch, K.A.6    Garrard, W.T.7
  • 12
    • 0024846566 scopus 로고
    • Immunoglobulin κ gene expression after stable integration I: Role of the intronic MAR and enhancer in plasmacytoma cells
    • Blasquez, V. C., M. Xu, S. C. Moss, and W. T. Garrard. 1989. Immunoglobulin κ gene expression after stable integration I: role of the intronic MAR and enhancer in plasmacytoma cells. J. Biol. Chem. 264:21183.
    • (1989) J. Biol. Chem. , vol.264 , pp. 21183
    • Blasquez, V.C.1    Xu, M.2    Moss, S.C.3    Garrard, W.T.4
  • 13
    • 0024790860 scopus 로고
    • Immunoglobulin κ gene expression after stable integration: Role of the intronic MAR and enhancer in transgenic mice
    • Xu, M., R. E. Hammer, V. C. Blasquez, S. A. Jones, and W. T. Garrard. 1989. Immunoglobulin κ gene expression after stable integration: role of the intronic MAR and enhancer in transgenic mice. J. Biol. Chem. 264:21190.
    • (1989) J. Biol. Chem. , vol.264 , pp. 21190
    • Xu, M.1    Hammer, R.E.2    Blasquez, V.C.3    Jones, S.A.4    Garrard, W.T.5
  • 14
    • 0031009483 scopus 로고    scopus 로고
    • Cells strongly expressing Igκ transgenes show clonal recruitment of hypermutation: A role for both the MAR and the enhancers
    • Goyenechea, B., N. Klix, J. Yelamos, G. T. Williams, A. Riddell, M. S. Neuberger, and C. Milstein. 1997. Cells strongly expressing Igκ transgenes show clonal recruitment of hypermutation: a role for both the MAR and the enhancers. EMBO J. 16:3987.
    • (1997) EMBO J. , vol.16 , pp. 3987
    • Goyenechea, B.1    Klix, N.2    Yelamos, J.3    Williams, G.T.4    Riddell, A.5    Neuberger, M.S.6    Milstein, C.7
  • 15
    • 0022442812 scopus 로고
    • Evolution of the immunoglobulin κ light chain locus in the rabbit: Evidence for differential gene conversion events
    • Akimenko, M.-A., B. Mariame, and F. Rougeon. 1986. Evolution of the immunoglobulin κ light chain locus in the rabbit: evidence for differential gene conversion events. Proc. Natl. Acad. Sci. USA 83:5180.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5180
    • Akimenko, M.-A.1    Mariame, B.2    Rougeon, F.3
  • 16
    • 0021109002 scopus 로고
    • Structural analysis of a rabbit immunoglobulin κ2 J-C locus reveals multiple deletions
    • Emorine, L., and E. E. Max. 1983. Structural analysis of a rabbit immunoglobulin κ2 J-C locus reveals multiple deletions. Nucleic Acids Res. 11:8877.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 8877
    • Emorine, L.1    Max, E.E.2
  • 17
    • 0028328632 scopus 로고
    • B cell-specific demethylation: A novel role for the intronic κ chain enhancer sequence
    • Lichtenstein, M., G. Keini, H. Cedar, and Y. Bergman. 1994. B cell-specific demethylation: a novel role for the intronic κ chain enhancer sequence. Cell 76:913.
    • (1994) Cell , vol.76 , pp. 913
    • Lichtenstein, M.1    Keini, G.2    Cedar, H.3    Bergman, Y.4
  • 19
    • 0029967078 scopus 로고    scopus 로고
    • Deletion of the Igκ light chain intronic enhancer/matrix attachment region impairs but does not abolish Vκ-Jκ rearrangement
    • Xu, Y., L. Davidson, F. W. Alt, and D. Baltimore. 1996. Deletion of the Igκ light chain intronic enhancer/matrix attachment region impairs but does not abolish Vκ-Jκ rearrangement. Immunity 4:377.
    • (1996) Immunity , vol.4 , pp. 377
    • Xu, Y.1    Davidson, L.2    Alt, F.W.3    Baltimore, D.4
  • 20
    • 0024669291 scopus 로고
    • A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
    • Sikorski, R. S., and P. Hieter. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19.
    • (1989) Genetics , vol.122 , pp. 19
    • Sikorski, R.S.1    Hieter, P.2
  • 21
    • 0019424257 scopus 로고
    • The nucleotide sequence of a 5.5 kilobase DNA segment containing the mouse κ immunoglobulin J and C region genes
    • Max, E. E., J. V. Maizel Jr., and P. Leder. 1981. The nucleotide sequence of a 5.5 kilobase DNA segment containing the mouse κ immunoglobulin J and C region genes. J. Biol. Chem. 256:5116.
    • (1981) J. Biol. Chem. , vol.256 , pp. 5116
    • Max, E.E.1    Maizel J.V., Jr.2    Leder, P.3
  • 22
    • 0000416248 scopus 로고
    • In vitro recombination and mutagenesis of DNA: SOEing together tailor-made genes
    • Horton, R. M. 1993. In vitro recombination and mutagenesis of DNA: SOEing together tailor-made genes. Methods Mol. Biol. 15:251.
    • (1993) Methods Mol. Biol. , vol.15 , pp. 251
    • Horton, R.M.1
  • 23
    • 0020529962 scopus 로고
    • Transformation of intact yeast cells treated with alkali cations
    • Ito, H., Y. Fukuda, K. Murata, and A. Kimura. 1983. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 53:163.
    • (1983) J. Bacteriol. , vol.53 , pp. 163
    • Ito, H.1    Fukuda, Y.2    Murata, K.3    Kimura, A.4
  • 24
    • 0025978949 scopus 로고
    • Getting started with yeast
    • Sherman, F. 1991. Getting started with yeast. Methods Enzymol. 194:3.
    • (1991) Methods Enzymol. , vol.194 , pp. 3
    • Sherman, F.1
  • 25
    • 0028711141 scopus 로고
    • Homologous recombination for gene replacement in mouse cell lines
    • Willnow, T. E., and J. Herz. 1994. Homologous recombination for gene replacement in mouse cell lines. Methods Cell Biol. 43:305.
    • (1994) Methods Cell Biol. , vol.43 , pp. 305
    • Willnow, T.E.1    Herz, J.2
  • 26
    • 0022968816 scopus 로고
    • Transcription termination and chromatin structure of the active immunoglobulin K gene locus
    • Xu, M., M. B. Barnard, S. M. Rose, P. N. Cockerill, S.-Y. Huang, and W. T. Garrard. 1986. Transcription termination and chromatin structure of the active immunoglobulin K gene locus. J. Biol. Chem. 261:3838.
    • (1986) J. Biol. Chem. , vol.261 , pp. 3838
    • Xu, M.1    Barnard, M.B.2    Rose, S.M.3    Cockerill, P.N.4    Huang, S.-Y.5    Garrard, W.T.6
  • 29
    • 0031719509 scopus 로고    scopus 로고
    • Accurate quantification of expression of transgenes marked with restriction endonuclease site polymorphisms by RT-PCR
    • Li, S., J. B. George-Raizen, R. E. Hammer, and W. T. Garrard. 1998. Accurate quantification of expression of transgenes marked with restriction endonuclease site polymorphisms by RT-PCR. BioTechniques 25:558.
    • (1998) BioTechniques , vol.25 , pp. 558
    • Li, S.1    George-Raizen, J.B.2    Hammer, R.E.3    Garrard, W.T.4
  • 30
    • 0000386558 scopus 로고
    • Northern hybridization of RNA fractionated by agarose-formaldehyde gel electrophoresis
    • John Wiley & Sons, New York
    • Brown, T. 1994. Northern hybridization of RNA fractionated by agarose-formaldehyde gel electrophoresis. In Current Protocols in Molecular Biology. John Wiley & Sons, New York, p. 4.9.2.
    • (1994) Current Protocols in Molecular Biology , pp. 492
    • Brown, T.1
  • 31
    • 0030917138 scopus 로고    scopus 로고
    • Coordinate transcription and V(D)J recombination of the κ immunoglobulin light-chain locus: NF-κB-dependent and independent pathways of activation
    • O'Brien, D. P., E. M. Oltz, and B. G. Van Ness. 1997. Coordinate transcription and V(D)J recombination of the κ immunoglobulin light-chain locus: NF-κB-dependent and independent pathways of activation. Mol. Cell. Biol. 17:3477.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 3477
    • O'Brien, D.P.1    Oltz, E.M.2    Van Ness, B.G.3
  • 32
    • 0024435908 scopus 로고
    • Activation of immunoglobulin κ gene rearrangement correlates with induction of germline κ gene transcription
    • Schlissel, M. S., and D. Baltimore. 1989. Activation of immunoglobulin κ gene rearrangement correlates with induction of germline κ gene transcription. Cell 58:1001.
    • (1989) Cell , vol.58 , pp. 1001
    • Schlissel, M.S.1    Baltimore, D.2
  • 33
    • 0027364313 scopus 로고
    • Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin κ light-chain transgenes
    • Gonzalez-Fernandez, A., and C. Milstein. 1993. Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin κ light-chain transgenes. Proc. Natl. Acad. Sci. USA 90:9862.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 9862
    • Gonzalez-Fernandez, A.1    Milstein, C.2
  • 34
    • 0031879159 scopus 로고    scopus 로고
    • Promoter-associated displacement of hypermutations
    • Wu, P., and L. Claflin. 1998. Promoter-associated displacement of hypermutations. Int. Immunol. 10:1131.
    • (1998) Int. Immunol. , vol.10 , pp. 1131
    • Wu, P.1    Claflin, L.2
  • 35
    • 0026429190 scopus 로고
    • Introduction of a subtle mutation into the Hox-2,6 locus in embryonic stem cells
    • Hasty, P., R. Ramirez-Solis, R. Krumlauf, and A. Bradley. 1991. Introduction of a subtle mutation into the Hox-2,6 locus in embryonic stem cells. Nature 350: 243.
    • (1991) Nature , vol.350 , pp. 243
    • Hasty, P.1    Ramirez-Solis, R.2    Krumlauf, R.3    Bradley, A.4
  • 37
    • 0029557123 scopus 로고
    • Yeast artificial chromosome contigs reveal that distal variable-region genes reside at least 3 megabases from the joining regions in the murine immunoglobulin κ locus
    • George, J. B., S. Li, and W. T. Garrard. 1995. Yeast artificial chromosome contigs reveal that distal variable-region genes reside at least 3 megabases from the joining regions in the murine immunoglobulin κ locus. Proc. Natl. Acad. Sci. USA 92:12421.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 12421
    • George, J.B.1    Li, S.2    Garrard, W.T.3
  • 38
    • 0031027608 scopus 로고    scopus 로고
    • A yeast artificial chromosome contig spanning the mouse immunoglobulin K light chain locus
    • Schupp, I. W., T. Schlake, T. Kirschbaum, H. G. Zacnau, and T. Boehm. 1997. A yeast artificial chromosome contig spanning the mouse immunoglobulin K light chain locus. Immunogenetics 45:180.
    • (1997) Immunogenetics , vol.45 , pp. 180
    • Schupp, I.W.1    Schlake, T.2    Kirschbaum, T.3    Zacnau, H.G.4    Boehm, T.5
  • 40
    • 0023120709 scopus 로고
    • Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice
    • Bucchini, D., C.-A. Reynaud, M.-A. Ripoche, H. Grimai, J. Jami, and J.-C. Weill. 1987. Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice. Nature 326:409.
    • (1987) Nature , vol.326 , pp. 409
    • Bucchini, D.1    Reynaud, C.-A.2    Ripoche, M.-A.3    Grimai, H.4    Jami, J.5    Weill, J.-C.6
  • 42
    • 0025868702 scopus 로고
    • Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow
    • Hardy, R. R., C. E. Carmack, S. A. Shinton, J. D. Kemp, and R. R. Hayakawa. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
    • (1991) J. Exp. Med. , vol.173 , pp. 1213
    • Hardy, R.R.1    Carmack, C.E.2    Shinton, S.A.3    Kemp, J.D.4    Hayakawa, R.R.5
  • 43
    • 0027369562 scopus 로고
    • Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes
    • Komori, T., A. Okada, V. Stewart, and F. W. Alt. 1993. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science 261:1171.
    • (1993) Science , vol.261 , pp. 1171
    • Komori, T.1    Okada, A.2    Stewart, V.3    Alt, F.W.4
  • 44
    • 0027452074 scopus 로고
    • Mice lacking TdT: Mature animals with an immature lymphocyte repertoire
    • Gilfillan, S., A. Dierich, M. Lemeur, C. Benoist, and D. Mathis. 1993. Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science 261:1175.
    • (1993) Science , vol.261 , pp. 1175
    • Gilfillan, S.1    Dierich, A.2    Lemeur, M.3    Benoist, C.4    Mathis, D.5
  • 45
    • 0028245640 scopus 로고
    • κ light chain rearrangement in mouse fetal liver
    • Ramsden, D. A., C. J. Paige, and G. E. Wu. 1994. κ light chain rearrangement in mouse fetal liver. J. Immunol. 153:1150.
    • (1994) J. Immunol. , vol.153 , pp. 1150
    • Ramsden, D.A.1    Paige, C.J.2    Wu, G.E.3
  • 46
    • 0028348205 scopus 로고
    • Limited junctional diversity in κ light chains
    • Victor, K. D., K. Vu, and A. J. Feeney. 1994. Limited junctional diversity in κ light chains. J. Immunol. 152:3467.
    • (1994) J. Immunol. , vol.152 , pp. 3467
    • Victor, K.D.1    Vu, K.2    Feeney, A.J.3
  • 47
    • 0031567975 scopus 로고    scopus 로고
    • Constitutive expression of terminal deoxynucleotidyl transferase in transgenic mice is sufficient for N region diversity to occur at any Ig locus throughout B cell differentiation
    • Bentolila, L. A., G. E. Wu, F. Nourrit, M. F. díAndon, F. Rougeon, and N. Doyen. 1997. Constitutive expression of terminal deoxynucleotidyl transferase in transgenic mice is sufficient for N region diversity to occur at any Ig locus throughout B cell differentiation. J. Immunol. 158:715.
    • (1997) J. Immunol. , vol.158 , pp. 715
    • Bentolila, L.A.1    Wu, G.E.2    Nourrit, F.3    Díandon, M.F.4    Rougeon, F.5    Doyen, N.6
  • 48
    • 0030249394 scopus 로고    scopus 로고
    • A prematurely expressed Igκ transgene, but not a VκJκ gene segment targeted into the Igκ locus, can rescue B cell development in λ5-deficient mice
    • Pelanda, R., S. Schaal, R. M. Torres, and K. Rajewsky. 1996. A prematurely expressed Igκ transgene, but not a VκJκ gene segment targeted into the Igκ locus, can rescue B cell development in λ5-deficient mice. Immunity 5:229.
    • (1996) Immunity , vol.5 , pp. 229
    • Pelanda, R.1    Schaal, S.2    Torres, R.M.3    Rajewsky, K.4
  • 49
    • 0025817171 scopus 로고
    • Somatic hypermutation of the JC intron is markedly reduced in unrearranged κ and H alleles and is unevenly distributed in rearranged alleles
    • Weber, J. S., J. Berry, S. Litwin, and J. L. Claflin. 1991. Somatic hypermutation of the JC intron is markedly reduced in unrearranged κ and H alleles and is unevenly distributed in rearranged alleles. J. Immunol. 146:3218.
    • (1991) J. Immunol. , vol.146 , pp. 3218
    • Weber, J.S.1    Berry, J.2    Litwin, S.3    Claflin, J.L.4
  • 50
    • 0028061856 scopus 로고
    • Mutations in Ig V(D)J genes are distributed asymmetrically and independently of the position of V(D)J
    • Weber, J. S., J. Berry, T. Manser, and J. L. Claflin. 1994. Mutations in Ig V(D)J genes are distributed asymmetrically and independently of the position of V(D)J. J. Immunol. 153:3594.
    • (1994) J. Immunol. , vol.153 , pp. 3594
    • Weber, J.S.1    Berry, J.2    Manser, T.3    Claflin, J.L.4
  • 51
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
    • Betz, A., C. Milstein, A. Gonzalez-Fernandez, R. Pannel, T. Larson, and M. Neuberger. 1994. Elements regulating somatic hypermutation of an immunoglobulin κ gene: critical role for the intron enhancer/matrix attachment region. Cell 77:239.
    • (1994) Cell , vol.77 , pp. 239
    • Betz, A.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannel, R.4    Larson, T.5    Neuberger, M.6
  • 52
    • 0028226831 scopus 로고
    • Human splenic IgM immunoglobulin transcripts are mutated at high frequency
    • Insel, R. A., W. S. Varade, and E. Marin. 1994. Human splenic IgM immunoglobulin transcripts are mutated at high frequency. Mol. Immunol. 31:383.
    • (1994) Mol. Immunol. , vol.31 , pp. 383
    • Insel, R.A.1    Varade, W.S.2    Marin, E.3
  • 53
    • 0032081254 scopus 로고    scopus 로고
    • Reevaluation of 3′ Eκ function in stage-and lineage-specific rearrangement and somatic hypermutation
    • Van der Stoep, N., J. R. Gorman, and F. W. Alt. 1998. Reevaluation of 3′ Eκ function in stage-and lineage-specific rearrangement and somatic hypermutation. Immunity 8:743.
    • (1998) Immunity , vol.8 , pp. 743
    • Van Der Stoep, N.1    Gorman, J.R.2    Alt, F.W.3
  • 54
    • 0029983727 scopus 로고    scopus 로고
    • Accessibility control of antigen-receptor variable-region gene assembly: Role of cis-acting elements
    • Sleckman, B., J. Gorman, and F. Alt. 1996. Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements. Annu. Rev. Immunol. 14:459.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 459
    • Sleckman, B.1    Gorman, J.2    Alt, F.3
  • 55
    • 0024472824 scopus 로고
    • Immunoglobulin κ light chain gene promoter and enhancer are not responsible for B-cell restricted rearrangement
    • Goodhardt, M., C. Babinet, G. Lutfalla, S. Kallenbach, P. Cavelier, and F. Rougeon. 1989. Immunoglobulin κ light chain gene promoter and enhancer are not responsible for B-cell restricted rearrangement. Nucleic Acids Res. 17:7403.
    • (1989) Nucleic Acids Res. , vol.17 , pp. 7403
    • Goodhardt, M.1    Babinet, C.2    Lutfalla, G.3    Kallenbach, S.4    Cavelier, P.5    Rougeon, F.6
  • 56
    • 0021257290 scopus 로고
    • Different joining region J elements of the murine κ immunoglobulin light chain locus are used at markedly different frequencies
    • Wood, D. L., and C. Coleclough. 1984. Different joining region J elements of the murine κ immunoglobulin light chain locus are used at markedly different frequencies. Proc. Natl. Acad. Sci. USA 81:4756.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 4756
    • Wood, D.L.1    Coleclough, C.2
  • 57
    • 0031975171 scopus 로고    scopus 로고
    • Multiple sequences from downstream of the Jκ cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain
    • Klix, N., C. J. Jolly, S. L. Davies, M. Bruggeman, G. T. Williams, and M. S. Neuberger. 1998. Multiple sequences from downstream of the Jκ cluster can combine to recruit somatic hypermutation to a heterologous, upstream mutation domain. Eur. J. Immunol. 28:317.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 317
    • Klix, N.1    Jolly, C.J.2    Davies, S.L.3    Bruggeman, M.4    Williams, G.T.5    Neuberger, M.S.6
  • 58
    • 0027305024 scopus 로고
    • In situ studies of the primary response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells
    • Jacob, J., J. Przylepa, C. Miller, and G. Kelsoe. 1993. In situ studies of the primary response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J. Exp. Med. 178:1293.
    • (1993) J. Exp. Med. , vol.178 , pp. 1293
    • Jacob, J.1    Przylepa, J.2    Miller, C.3    Kelsoe, G.4
  • 61
    • 0030839857 scopus 로고    scopus 로고
    • Chromatin-remodelling factor CHRAC contains the ATPases ISW1 and topoisomerase II
    • Varga-Weisz, P. D., M. Wilm, E. Bonte, K. Dumas, M. Mann, and P. B. Becker. 1997. Chromatin-remodelling factor CHRAC contains the ATPases ISW1 and topoisomerase II. Nature 388:598.
    • (1997) Nature , vol.388 , pp. 598
    • Varga-Weisz, P.D.1    Wilm, M.2    Bonte, E.3    Dumas, K.4    Mann, M.5    Becker, P.B.6
  • 62
    • 0030765923 scopus 로고    scopus 로고
    • H gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor
    • H gene repertoire of developing precursor B lymphocytes in mouse bone marrow mediated by the pre-B cell receptor. Immunity 7:357.
    • (1997) Immunity , vol.7 , pp. 357
    • Ten Boekel, E.1    Melchers, F.2    Rolink, A.G.3
  • 63
    • 0027476466 scopus 로고
    • Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development
    • Ehlich, A., S. Schaal, H. Gu, D. Kitamura, W. Muller, and K. Rajewsky. 1993. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72:695.
    • (1993) Cell , vol.72 , pp. 695
    • Ehlich, A.1    Schaal, S.2    Gu, H.3    Kitamura, D.4    Muller, W.5    Rajewsky, K.6
  • 64
    • 0030222767 scopus 로고    scopus 로고
    • The Ig-κ 3′ enhancer influences the ratio of Ig-κ versus Ig-λ B lymphocytes
    • Gorman, J. R., N. Vanderstoep, R. Monroe, M. Cogne, L. Davidson, and F. W. Alt. 1996. The Ig-κ 3′ enhancer influences the ratio of Ig-κ versus Ig-λ B lymphocytes. Immunity 5:241.
    • (1996) Immunity , vol.5 , pp. 241
    • Gorman, J.R.1    Vanderstoep, N.2    Monroe, R.3    Cogne, M.4    Davidson, L.5    Alt, F.W.6
  • 65
    • 0027309329 scopus 로고
    • Yeast calmodulin and a conserved nuclear protein participate in the in vivo binding of a matrix association region
    • Fishel, B. R., A. O. Sperry, and W. T. Garrard. 1993. Yeast calmodulin and a conserved nuclear protein participate in the in vivo binding of a matrix association region. Proc. Natl. Acad. Sci. USA 90:5623.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 5623
    • Fishel, B.R.1    Sperry, A.O.2    Garrard, W.T.3
  • 66
    • 0028880693 scopus 로고
    • Mutually exclusive interaction of a novel matrix attachment region binding protein and the NF-μNR enhancer repressor
    • Zong, R.-T., and R. H. Scheuermann. 1995. Mutually exclusive interaction of a novel matrix attachment region binding protein and the NF-μNR enhancer repressor. J. Biol. Chem. 270:24010.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24010
    • Zong, R.-T.1    Scheuermann, R.H.2
  • 67
    • 0030875133 scopus 로고    scopus 로고
    • A matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression
    • Liu, J., D. Bramblett, Q. Zhu, M. Lozano, R. Kobayashi, S. R. Ross, and J. P. Dudley. 1997. A matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression. Mol. Cell. Biol. 17:5275.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 5275
    • Liu, J.1    Bramblett, D.2    Zhu, Q.3    Lozano, M.4    Kobayashi, R.5    Ross, S.R.6    Dudley, J.P.7
  • 68
    • 0031915974 scopus 로고    scopus 로고
    • A nuclear matrix/scaffold attachment region co-localizes with the gypsy retrotransposon insulator sequence
    • Nabirochkin, S., M. Ossokina, and T. Heidmann. 1998. A nuclear matrix/scaffold attachment region co-localizes with the gypsy retrotransposon insulator sequence. J. Biol. Chem. 273:2473.
    • (1998) J. Biol. Chem. , vol.273 , pp. 2473
    • Nabirochkin, S.1    Ossokina, M.2    Heidmann, T.3
  • 69
    • 0030922269 scopus 로고    scopus 로고
    • The role of insulator elements in defining domains of gene expression
    • Geyer, P. K. 1997. The role of insulator elements in defining domains of gene expression. Curr. Opin. Genet. Dev. 7:242.
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 242
    • Geyer, P.K.1
  • 70
    • 0031790033 scopus 로고    scopus 로고
    • A targeted κ immunoglobulin gene containing a deletion of the nuclear matrix association region exhibits hyper-recombination in pre-B cells
    • Hale, M. A., and W. T. Garrard. 1998. A targeted κ immunoglobulin gene containing a deletion of the nuclear matrix association region exhibits hyper-recombination in pre-B cells. Mol. Immunol. 35:609.
    • (1998) Mol. Immunol. , vol.35 , pp. 609
    • Hale, M.A.1    Garrard, W.T.2


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