Growth hormone in immune reconstitution

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 20, Issue 5, 1999, Pages 423-431

  Chappel, Scott ^a  

^a EMD SERONO INC   (United States)

Author keywords

Growth hormone; Hematopoiesis; HIV; Immune reconstitution; Lymphopoiesis; Thymus

Indexed keywords

CYCLOSPORIN; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; SOMATOMEDIN C; ZIDOVUDINE;

ANIMAL MODEL; ARTICLE; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; HEMATOPOIESIS; HORMONE RECEPTOR INTERACTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMUS; VIRUS INFECTION;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; RNA VIRUSES;

EID: 0033560738     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199904150-00003     Document Type: Article

References (132)

1. Thorner MO, Chapman IM, Gaylinn BD, et al. Growth hormone releasing hormone and growth hormone releasing peptide as therapeutic agents to enhance growth hormone secretion in disease and aging. Rec Prog Horm Res 1997;52:215-44
2. Wells JA, Cunningham BC, Fuh G, et al. The molecular basis for growth hormone-receptor interactions. Recent Prog Horm Res 1993;48:253-75.
3. Horseman ND, Yu-Lee LY. Transcriptional regulation by the helix bundle peptide hormones: growth hormone, prolactin, and hematopoietic cytokines. Endocr Rev 1994;15:627-49
4. Wells JA, de Vos AM. Structure and function of human growth hormone: implications for the hematopoietins. Ann Rev Biophys Biomol Struct 1993;22:329-51.
5. Demchuk E, Mueller T, Oschkinat H, Sebald W, Wade RC. Receptor binding propertïes of four-helix-bundle growth factors deduced from electrostatic analysis. Protein Sci 1994;3:920-35.
6. Hooghe R, Delhase M, Vergani P, Malur A, Hooghe-Peters EL. Growth hormone and prolactin are paracrine growth and differentiation factors in the haemopoietic system. Immunol Today 1993;14:212-14.
7. Kiess W, Butenandt O. Specific growth hormone receptors on human peripheral mononuclear cells: reexpression, identification and characterization. J Clin Endocrinol Metabol 1985;60:740-6.
8. Clark R. The somatogenic hormones and insulin-like growth factor-1: stimulators of lymphopoiesis and immune function. Endocr Rev 1997;18:2,157-79.
9. Chen HT, Schuler LA, Schultz RD. Growth hormone and Pit-1 expression in bovine fetal lymphoid cells. Domest Anim Endocrinol 1997;14:399-407.
10. Dardenne M, De Mello-Coelho V, Gagnerault MC, Postel-Vinay MC. Growth hormone receptors and immunocompetent cells. Ann N Y Acad Sci 1998;840:510.
11. De Mello-Coelho V, Ganerault MC, Souberbielle JC, et al. Growth hormone and its receptor are expressed in human thymic cells. Endocrinology 1998;139:3837-42.
12. Badolaro R, Bond HM, Valerio G, et al. Differential expression of surface membrane growth hormone receptors on human peripheral blood lymphocytes detected by dual fluorochrome flow cytometry. J Clin Endocrin Metabol 1994;79:984-90.
13. Rapaport R, Sills IN, Barrett P, et al. Detection of human growth hormone receptors on IM-9 cells and peripheral blood mononuclear cell subsets by flow cytometry: correlation with growth hormone binding protein levels. J Clin Endocrin Metabol 1995; 80:2612-19.
14. Gagnerault MC, Postel-Vinay MC, Dardenne M. Expression of growth hormone receptors in murine lymphoid cells analyzed by flow cytofluorometry. Endocrinology 1996;137:5,1719-26.
15. Kooijman R, Berus D, Malur A. Delhase M, Hooghe-Peters EL. Human neutrophils express GH-N gene transcripts and the pituitary transcription factor Pit-1b. Endocrinology 1997;138: 4481-4.
16. Ban E, Gagnerault MC, Jammes H, Postel-Vinay MC, Haour F, Dardenne M. Specific binding sites for growth hormone in cultured mouse thymic epithelial cells. Life Sci 1991;48:2141-8.
17. Delhase M, Vergani P, Malur A, Hooghe-Peters EL, Hooghe RJ. The transcription factor Pit1/GHF-1 is expressed in hemopoietic and lymphoid tissues. Eur J Immunol 1993;23:951-5.
18. Kooijman R, Malur A, Van Buul-Offers SC, Hooghe-Peters EL. Growth hormone expression in murine bone marrow cells is independent of the pituitary transcription factor, Pit-1. Endocrinology 1997;138:3949-55.
19. Binder G, Revskoy S, Gupta D. In vivo growth hormone gene expression in neonatal rat thymus and bone marrow. J Endocrinol 1994;140:137-43.
20. Palmetshofer A, Zechner S, Luger TA, Barta A. Splicing variants of the human growth hormone mRNA:detection in pituitary, mononuclear and dermal fibroblasts. Mol Cell Endocrinol 1995; 113:225-34.
21. Rohn WM, Weigent DA. Cloning and nucleotide sequencing of rat lymphocyte growth hormone cDNA. Neuroimmunomodulation 1995;2:108-4.
22. Weigent DA, Baxter JB, Wear WE, Smith LR, Bost KL, Blalock JE. Production of immunoreactive growth hormone by mononuclear leukocytes. FASEB J 1988;2:2812-18.
23. Geffner ME, Bersch N, Lippe BM, Rosenfeld RG, Hintz RL, Golde DW. Growth hormone mediates the growth of T-lymphoblast cell lines via locally generated insulin-like growth factor-I. J Clin Endocrinol Metabol 1990;71:464-9.
24. Baxter JB, Blalock JE, Weigent DA. Characterization of immunoreactive insulin-like growth factor-I from leukocytes and its regulation by growth hormone. Endocrinol 1991;129:1727-34.
25. Hattori N, Shimomura K, Ishihara T, et al. Growth hormone (GH) secretion from human lymphocytes is up-regulated by GH, but not affected by insulin-like growth factor-I. J Clin Endocrinol Metab 1993;76:937-9.
26. Hattori N, Ikekubo K, Ishihara T, Moridera K, Hino M, Kurahachi H. Spontaneous growth hormone (GH) secretion by unstimulated human lymphocytes and the effects of GH-releasing hormone and somatostatin. J Clin Endocrin Metabol 1994;79:1678-80.
27. Varma S, Sabharwal P, Sheridan JF, Malarkey WB. Growth hormone secretion by human peripheral blood mononuclear cells detected by an enzyme-linked immunoplaque assay. J Clin Endocrinol Metab 1993;76:49-53.
28. Maggiano N, Piantelli M, Ricci R, Larocca LM, Capelli A, Ranelletti FO. Detection of growth hormone-producing cells in human thymus by immunohistochemistry and non-radioactive in situ hybridization. J Histochem Cytochem 1994;42:1349-54.
29. Sabharwal P, Varma S. Growth hormone synthesized and secreted by human thymocytes acts via insulin-like growth factor I as an autocrine and paracrine growth factor. J Clin Endocrinol Metab 1996;81:2663-9.
30. Wu H, Devi R, Malarkey WB. Localization of growth hormone messenger ribonucleic acid in the human immune system - a clinical research center study. J Clin Endocrinol Metab 1996;81: 1278-82.
31. Pierpaoli W, Sorkin E. Hormones and immunologic capacity. I. Effect of heterologous anti-growth hormone (ASTH) antiserum on thymus and peripheral lymphatic tissue in mice. Induction of a wasting syndrome. J Immunol 1968;101:1036-43.
32. Berczi I, Nagy E, Asa SL, Kovacs, K. Pituitary hormones and contact sensitivity in rats. Allergy 1983;38:325-30.
33. Weigent DA, Blalock JE, LeBoeuf RD. An antisense oligodeoxynucleotide to growth hormone messenger ribonucleic acid inhibits lymphocyte proliferation. Endocrinology 1991;128:2053-7.
34. Fabris N, Mocchegiani E, Provinciali M. Plasticity of neuroendocrine-thymus interactions during aging - a minireview. Cell Mol Biol 1997;43:29-41.
35. Montecino-Rodriguez E, Clark R, Dorshkind K. Effects of insulin-like growth factor administration and bone marrow transplantation on thymopoiesis in aged mice. Endocrinology 1998;139: 4120-6.
36. Gelato MC. Aging and immune function: a possible role for growth hormone. Horm Res 1996;45:1-2,46-9.
37. Kelley KW, Brief S, Westly HJ, Novakofski J, Bechtel PJ, Simon J. GH3 pituitary adenoma cells can reverse thymic aging in rats. Proc Natl Acad Sci USA 1986;83:5663-7.
38. Davila DR, Brief S, Simon J, Hammer RE, Brinster RL, Kelley KW. Role of growth hormone in regulating T-dependent immune events in aged, nude and transgenic rodents. J Neurosci Res 1987; 18:108-16.
39. Goff BL, Roth JA, Arp LH, Incefy GS. Growth hormone treatment stimulates thymulin production in aged dogs. Clin Exp Immunol 1987;68:580-7.
40. Mocchegiani E, Paolucci P, Balsamo A, et al. Influence of growth hormone on thymic endocrine activity in humans. Horm Research 1990;33:248-55.
41. Goya RG, Gagnerault MC, Sosa YE, Bevilacqua JA, Dardenne M. Effects of growth hormone and thyroxine on thymulin secretion in aging rats. Neuroendocrinology 1993;58:338-43.
42. Kelley KW. Immunologic roles of two metabolic hormones, growth hormone and insulin-like growth factor-I, in aged animals. Nutr Rev 1995;53:S95-103.
43. LeRoith D, Yanowski J, Kaldjian EP, et al. The effects of growth hormone and insulin-like growth factor I on the immune system of aged female monkeys. Endocrinology 1996;137:1071-9.
44. Mosley RL. Aging, immunity and neuroendocrine hormones. Adv Neuroimmunol 1996;6:419-32.
45. Khorram O, Laughlin GA, Yen SS. Endocrine and metabolic effects of long-term administration of [NIe27] growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women. J Clin Endocrinol Metabol 1997;82:1472-9.
46. Khorram O, Yeung M, Vu L, Yen S. Effects of [norleucine27] growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women. J Clin Endocrin Metabol 1997;82:3590-6.
47. Douek DC, McFarland RD, Keiser PH, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998;396:690-5.
48. Gelato MC. Growth hormone-insulin like growth factor I and immune function. Trends Endocrinol Metabol 1993;4:106-10.
49. Auernhammer CJ, Strasburger CJ. Effects of growth hormone and insulin-like growth factor I on the immune system. Eur J Endocrinol 1995;133:635-45.
50. Postel-Vinay MC, de Mello-Coelho V, Gagnerault MC, Dardeene M. Growth hormone stimulates the proliferation of activated mouse T lymphocytes. Endocrinology 1997;138:1816-20.
51. Berczi I, Nagy E, De Toledo SM, Matusik RJ, Friesen HG. Pituitary hormones regulate c-myc and DNA synthesis in lymphoid tissue. J Immunol 1991;146:2201-6.
52. Gala RR. Prolactin and growth hormone in the regulation of the immune system. Proc Soc Exp Biol Med 1991;198:513-27
53. Murphy WJ, Durum SK, Longo DL. Role of neuroendocrine hormones in murine T cell development. Growth hormone exerts thymopoietic effects in vivo. J Immunol 1992;149:3851-7.
54. Berczi I. The role of the growth and lactogenic hormone family in immune function. Neuroimmunodulation 1994;1:201-16.
55. Dardenne M, Savino W. Control of thymus physiology by peptidic hormones and neuropeptides. Immunol Today 1994;15:518-20.
56. Timsit J, Savino W, Safieh B, et al. Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells. J Clin Endocrinol Metab 1992;75: 183-8.
57. Fukushima R, Hato F, Kinoshita Y, Tsuji K, Kitano A. Effect of exogenous growth hormone on in vitro proliferation of thymic lymphocytes from the hypophysectomized rats. Cell Mol Biol 1997;43:567-79.
58. Lin B, Kinoshita Y, Hato F, Tsuji Y. Enhancement of DNA synthetic activity of thymic lymphocytes by the culture supernatant of thymus epithelial cells stimulated by growth hormone. Cell Mol Biol 1997;43:351-9.
59. Robert F, Beenen V. Thymic neuropeptides and T cell development. Ann N Y Acad Sci 1992;650:99-104.
60. Weigent DA. Immunoregulatory properties of growth hormone and prolactin. Pharmacol Ther 1996;69:237-57.
61. Murphy WJ, Rui H, Longo DL. Effects of growth hormone and prolactin immune development and function. Life Sci 1995;57:1-14.
62. Kelley KW, Arkins S, Minshall C, Liu Q, Dantzer R. Growth hormone, growth factors and hematopoiesis. Horm Res 1996;45: 38-45.
63. Chen H, Schuler LA, Schultz RD. Growth hormone receptor and regulation of gene expression in fetal lymphoid cells. Mol Cell Endocrinol 1998;137:21-9.
64. Taub DD, Tsarfaty G, Lloyd AR, Durum SK, Longo DL, Murphy WJ. Growth hormone promotes human T cell adhesion and migration to both human and murine matrix proteins in vitro and directly promotes xenogeneic engraftment. J Clin Invest 1994;94: 293-300.
65. De Mello-Coelho V, Villa-Verde DM, Dardenne M, Savino W. Pituitary hormones modulate cell-cell interactions between thymocytes and thymic epithelial cells. J Neuroimmunol 1997;76: 39-49.
66. Kooijman R, Willems M, Rijkers GT, et al. Effects of insulin-like growth factors and growth hormone on the in vitro proliferation of T lymphocytes. J Neuroimmunol 1992;38:95-104.
67. Geffner M. Effects of growth hormone and insulin-like growth factor I on T -and B-lymphocytes and immune function. Acta Paediatr Suppl 1997;423:76-9.
68. Snow EC, Feldbush TL, Oakes JA. The effect of growth hormone and insulin upon MLC responses and the generation of cytotoxic lymphocytes. J Immunol 1981;126:161-4.
69. Benfield MR, Vail A, Weigent DA. Recombinant human growth hormone augments responses in the mixed leukocyte culture. Transplant Proc 1994;26:84.
70. Murphy WJ, Durum SK, Longo DL. Differential effects of growth hormone and prolactin on murine T cell development and function. J Exp Med 1993;178:231-6.
71. Mellado M, Llorente M, Rodriguez-Frade M, Lucas P, Martinez-A C, del Real G. HlV-1 envelope protein gp120 triggers a Th2 response in mice that shifts to Th1 in the presence of human growth hormone. Vaccine 1998;15:1111-15.
72. Bidlingmaier M, Auernhammer CJ, Feldmeier H, Strasburger CJ. Effects of growth hormone and insulin - like growth factor I binding to natural killer cells. Acta Paediatr Suppl 1997;423: 80-1.
73. Crist DM, Peake GT, Mackinnon LT, Sibbitt WL, Kraner JC. Exogenous growth hormone treatment alters body composition and increases natural killer cell activity in women with impaired endogenous growth hormone secretion. Metabolism 1987;36: 1115-17.
74. Bozzola M, Valtorta A, Moretta A, Cisternino M, Biscaldi I, Schimpff R. In vitro and in vivo effect of growth hormone on cytotoxic activity. J Pediatr 1990;117:596-9.
75. Yoshida A, Ishioka C, Kimata H, Mikawa H. Recombinant human growth hormone stimulates B cell immunoglobulin synthesis and proliferation in serum-free media. Acta Endocrinol (Copenh) 1992;126:524-9.
76. Kimata H, Yoshida A. Effect of growth hormone and insulin-like growth factor-I on immunoglobulin production by and growth of human B cells. Blood 1991;78:635-41.
77. Kimata H, Yoshida A. Differential effect of growth hormone and insulin-like growth factor-I, insulin-like growth factor-II, and insulin on Ig production and growth in human plasma cells. Blood 1994;83:1569-74.
78. Kimata H, Fujimoto M. Growth hormone and insulin-like growth factor I induce immunoglobin (Ig)E and IgG4 production by human B cells. J Exp Med 1994;180:727-32.
79. Rapaport R, Bozzola M. Role of B-cells in growth hormone-immune interactions. Acta Paediatr Suppl 1997;423:82-3.
80. Wit JM, Kooijman R, Rijkers GT, Zegers BJ. Immunological findings in growth hormone-treated patients. Horm Res 1993;39: 107-10.
81. Wiedermann CJ, Reinisch N, Braunsteiner H. Stimulation of monocyte chemotaxis by human growth hormone and its deactivation by somatostatin. Blood 1993;82:954-60.
82. Edwards CK, Ghiasuddin SM, Schepper JM, Yunger LM, Kelley KM. A newly defined property of somatotropin: priming of macrophages for production of superoxide anion. Science 1988;239: 767-71.
83. Fu YK, Arkins S, Wany BS, Kelley KW. A novel role of growth hormone and insulin-like growth factor-I. Priming neutrophils for superoxide anion secretion. J Immunol 1991;146:1602-8.
84. Wiedermann CJ, Reinisch N, Niedermuhlbichler M, Braunsteiner H. Inhibition of recombinant human growth hormone-induced and prolactin-induced activation of neutrophils by octreotide. Naunyn Schmiedebergs Arch Pharmacol 1993;347:336-41.
85. Merchav S, Tatarsky I, Hochberg Z. Enhancement of human granulopoiesis in vitro by biosynthetic insulin like growth factor/ somatomedin C and human growth hormone. J Clin Invest 1988; 81:791-7.
86. Murphy WJ, Tsarfaty G, Longo DL. Growth hormone exerts hematopoietic growth-promoting effects in vivo and partially counteracts the myelosuppressive effects of azidothymidine. Blood 1992;80:1443-7.
87. Kelley KW, Meier WA, Minshall C, et al. Insulin growth factor-I inhibits apoptosis in hematopoietic progenitor cells. Implications for thymic aging. Ann NY Acad Sci 1998;840:518-24.
88. Kiess W, Gallaher B. Hormonal control of programmed cell death/apoptosis. Eur J Endocrinol 1998;138:482-91.
89. Golde DW, Bersch N, Li CH. Growth hormone: species specific stimulation of erythropoiesis in vitro. Science 1976;196:1112-14.
90. Ten Have SM, van der Lely AJ, Lamberts SW. Increase in haemoglobin concentrations in growth hormone deficient adults during human recombinant growth hormone replacement therapy. Clin Endocrinol 1997;47:565-70.
91. Christ ER, Cummings MH, Westwood NB, et al. The importance of growth hormone in the regulation of erythropoiesis, red cell mass and plasma volume in adults with growth hormone deficiency. J Clin Endocrinol Metabol 1997;82:2985-90.
92. Murphy WJ, Durum SK, Longo DL. Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice. Proc Natl Acad Sci USA 1992;89: 4481-5.
93. Murphy WJ, Durum SK, Anver M, Frazier M, Longo DL. Recombinant human growth hormone promotes human lymphocyte engraftment in immunodeficient mice and results in an increased incidence of human Epstein Barr virus-induced B-cell lymphoma. Brain Behav Immunol 1992;6:355-64.
94. Tsarfaty G, Longo DL, Murphy WJ. Human insulin-like growth factor I exerts hematopoietic growth-promoting effects after in vivo administration. Exp Hematol 1994;22:1273-7.
95. Beschorner WE, Divic J, Pulido H, et al. Enhancement of thymic recovery after cyclosporine by recombinant human growth hormone and insulin-like growth factor-1. Transplantation 1991;52: 879-84.
96. Li S, Crenshaw EB, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG. Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene, pit-1. Nature 1990;347:528-33.
97. Baroni CD, Fabris N, Bertoli G. Effects of hormones on development and function of lymphoid tissue. Synergistic action of thyroxin and somatotropic hormone in pituitary dwarf mice. Immunology 1969;17:303-14.
98. Fabris N, Pierpaoli W, Sorkin E. Hormones and the immunological capacity. III. The immunodeficiency disease of the hypopituitary Snell-Bagg dwarf mouse. Clin Exp Immunol 1971;9:209-25.
99. Murphy WJ, Durum SK, An ver MR, Longo DL. Immunologic and hematologic effects of neuroendocrine hormones. Studies on DW/J dwarf mice. J Immunol 1992;148:3799-3805.
100. Schurmann A, Spencer GS, Berry CJ. Growth hormone alters lymphocyte sub-populations and antibody production in dwarf rats in vivo. Experientia 1995;51:780-5.
101. Weigent DA, Blalock JE. Effect of the administration of growth-hormone-producing lymphocytes on weight gain and immune function in dwarf mice. Neuroimmunodulation 1994;1:50-8.
102. Blazar BR, Brennan CA, Broxmeyer HE, Shultz LD, Vallera DA. Transgenic mice expressing either bovine growth hormone (bGH) or human GH releasing hormone (hGRH) have increased splenic progenitor cell colony formation and DNA synthesis in vitro and in vivo. Exp Hematol 1995;23:1397-1406.
103. Abbassi V, Ballanti JA. Humoral and cell-mediated immunity in growth hormone-deficient children: effect of therapy with human growth hormone. Pediatr Res 1985;19:299-301
104. Rapaport R, Oleske J, Ahdieh H, Solomon S, Delfaus C, Denny T. Suppression of immune function in growth hormone-deficient children during treatment with human growth hormone. J Pediatr 1986;109:434-9.
105. Rapaport R, Oleske J, Ahdieh H, et al. Effects of human growth hormone on immune functions: in vitro studies on cells of normal and growth hormone-deficient children. Life Sci 1987;41:2319-24.
106. Peterson BH, Rapaport R, Henry DP, Huseman C, Moore WV. Effect of treatment with biosynthetic human growth hormone (GH) on peripheral blood lymphocyte populations and function in growth hormone-deficient children. J Clin Endocrinol Metab 1990;70:1756-60.
107. Spadoni GL, Rossi P, Ragno W, et al. Immune function in growth hormone-deficient children treated with biosynthetic growth hormone. Acta Paediatr Scand 1991;80:75-9.
108. Kappel M, Hansen MB, Diamant M, Jorgensen JOL, Gyhrs A, Pedersen BK. Effects of an acute bolus growth hormone infusion on the human immune system. Horm Metab Res 1993;25:579-85.
109. Carroll PV, Christ ER, Bengtsson BA, et al. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. J Clin Endocrin Metabol 1998;83:382-95.
110. Kundig TM, Schorle H, Bachmann MF, Hengartner H, Zinkernagel RM, Horak I. Immune responses in interleukin-2-deficient mice. Science 1993;262:1059-61.
111. Li XC, Roy-Chaudhury P, Hancock WW, et al. IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection. J Immunology 1998;161: 890-6.
112. Stanley SK, McCune JM, Kaneshima H, et al. Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. J Exp Med 1993;178:1151-63.
113. Braun J, Valentin H, Nugeyre MT, et al. Productive and persistent infection of human thymic epithelial cells in vitro with HIV-1. Virology 1996;225:413-18.
114. + cell depletion in human immunodeficiency virus type 1-infected SCID-hu mice suggest direct viral killing of the thymocytes in vivo. J Virol 1997;71:8245-53.
115. Wykrzykowska JJ, Rosenzweig M, Veazey RS, et al. Early regeneration of the thymic progenitors in rhesus macaques infected with simian immunodeficiency virus. J Exp Med 1998;187:1767-78.
116. McCune JM. Thymic function in HIV-1 disease. Semin Immunol 1997;9:397-404.
117. Nahmias AJ, Clark WS, Kourtis AP, et al. Thymic dysfunction and time of infection predict mortality in human immunodeficiency virus-infected infants. CDC Perinatal AIDS Collaborative Transmission Study Group. J Infect Dis 1998;178:680-5.
118. Harris PJ, Candelor PD, Bunn JE. HIV infection of the adult thymus: an even more conventional theory explaining CD4 cell decrease and CDS cell increase in AIDS. Med Hypotheses 1991; 36:379-80.
119. Autran B, Guiet P, Raphael M, et al. Thymocyte and thymic microenvironment alterations during a systemic HIV infection in a severe combined immunodeficient mouse model. AIDS 1996; 10:717-27.
120. Fauci AS, Pantaleo G, Stanley S, Weissman D. Immunopathogenic mechanisms of HIV infection. Ann Intern Med 1996;124: 654-63.
121. Jenkins M, Hanley MB, Moreno MB, et al. Human immunodeficiency virus-1 infection interrupts thymopoiesis and multilineage hematopoiesis in vivo. Blood 1998;91:2672-8.
122. Koka PS, Fraser JK, Bryson Y, et al. Human immunodeficiency virus inhibits multilineage hematopoiesis in vivo. J Virol 1998; 72:5121-7.
123. Bonyhadi ML, Rabin L, Salimi S, et al. HIV induces thymus depletion in vivo. Nature 1993;363:728-32.
124. Knight SC, Patterson S. Bone marrow-derived dendritic cells, infection with human immunodeficiency virus, and immunopathology. Annu Rev Immunol 1997;15:593-615.
125. Gaulton GN. Viral pathogenesis and immunity within the thymus. Immunol Res 1998;17:75-82.
126. Rothe M, Chene L, Nugeyre MT, et al. Contact with thymic epithelial cells as a prerequisite for cytokine-enhanced human immunodeficiency virus type 1 replication in thymocytes. J Virol 1998;72:5852-61.
127. Mackall CL, Gress RE. Thymic aging and T-cell regeneration. Immunol Rev 1997;160:91-102.
128. Withers-Ward ES, Amado RG, Koka PS, et al. Transient renewal of thymopoiesis in HIV-infected human thymic implants following antiviral therapy. Nat Med 1997;3:1102-9.
129. Schambelan, M., Mulligan, K., Grunfeld, C., et al., 1996. Recombinant human growth hormone in patients with HIV-associated wasting. A randomized, placebo-controlled trial. Serostim Study Group. Ann Intern Med 125:873-82.
130. Nguyen B, Clerici M, Venzon DJ. Pilot study of immunological effects of recombinant human growth hormone and recombinant insulin-like growth factor in HIV-infected patients. AIDS Res Hum Retroviruses 1998;12:895-904.
131. Knyszynski A, Adler-Kunin S, Globerson A. Effects of growth hormone on thymocyte development from progenitor cells in the bone marrow. Brain Behav Immunol 1992;6:327-40.
132. Hirschfeld S. Use of human recombinant growth hormone and human recombinant insulin-like growth factor-I in patients with human immunodeficiency virus infection. Horm Res 1996;46: 4-5, 215-21.