Clinical features and anti-neural reactivity in neuropathy associated with IgG monoclonal gammopathy of undetermined significance

Journal of the Neurological Sciences

Volumn 164, Issue 1, 1999, Pages 64-71

  Di Troia, A ^a   Carpo, M ^a   Meucci, N ^a   Pellegrino, C ^a   Allaria, S ^a   Gemignani, F ^b   Marbini, A ^b   Mantegazza, R ^c   Sciolla, R ^d   Manfredini, E ^a   Scarlato, G ^a   Nobile Orazio, E ^a  

^a 'Giorgio Spagnol' Serv Clin N   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c DEPARTMENT OF NEUROSURGERY   (Italy)

^d Ospedale di Ivrea   (Italy)

Author keywords

Autoantibodies; Chondroitin sulfate C; CIDP; IgG; Monoclonal gammopathy; Neuropathy; Tubulin

Indexed keywords

GLYCOPROTEIN; M PROTEIN; TUBULIN;

ADULT; AGED; ANTIBODY TITER; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; DEMYELINATING DISEASE; DISEASE ASSOCIATION; FEMALE; HUMAN; IMMUNE RESPONSE; MALE; MONOCLONAL IMMUNOGLOBULINEMIA; NERVE FIBER; NEUROPATHY; POLYNEUROPATHY; PRIORITY JOURNAL;

ADULT; AGED; DEMYELINATING DISEASES; FEMALE; HEREDITARY MOTOR AND SENSORY NEUROPATHIES; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOTHERAPY; MALE; MIDDLE AGED; PARAPROTEINEMIAS; SURAL NERVE;

EID: 0033560048     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(99)00049-0     Document Type: Article

References (54)

1. Kelly J.J., Kyle R.A., O'Brien P.C., Dyck P.J. Prevalence of monoclonal protein in peripheral neuropathy. Neurology. 31:1981;1480-1483.
2. Osby E., Noring L., Hast R., Kjellin K.G., Knutsson E., Siden A. Benign monoclonal gammopathy and peripheral neuropathy. Br J Hematol. 51:1982;531-539.
3. Krol-v Straaten M.J., Ackerstaff R.G.A., De Maat C.E.M. Peripheral polyneuropathy and monoclonal gammopathy of undetermined significance. J Neurol Neurosurg Psychiatry. 48:1985;706-708.
4. Gosselin S., Kyle R.A., Dyck P.J. Neuropathy associated with monoclonal gammopathies of undetermined significance. Ann Neurol. 30:1991;54-61.
5. Yeung K.B., Thomas P.K., King R.H.M., Waddy H., Will R.G. The clinical spectrum of peripheral neuropathies associated with benign monoclonal IgM, IgG and IgA paraproteinaemia. Comparative clinical, immunological and nerve biopsy findings. J Neurol. 238:1991;383-391.
6. Nobile-Orazio E., Barbieri S., Baldini L., Marmiroli P., Carpo M., Premoselli S., Manfredini E., Scarlato G. Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies. Acta Neurol Scand. 85:1992;383-390.
7. Vrethem M., Cruz M., Wen-Xin H., Malm C., Holmgren H., Ernerudh J. Clinical, neurophysiological and immunological evidence of polineuropathy in patients with monoclonal gammopathies. J Neurol Sci. 114:1993;193-199.
8. Suarez G.A., Kelly J.J. Polyneuropathy associated with monoclonal gammopathy of undetermined significance: further evidence that IgM-MGUS neuropathies are different than IgG-MGUS. Neurology. 43:1993;1304-1308.
9. Notermans N.C., Wokke J.H.J., Lokhorst H.M., Franssen H., Van der Graaf Y., Jennekens F.G.I. Polyneuropathy associated with monoclonal gammopathy of undetermined significance. A prospective study of the prognostic value of clinical and laboratory abnormalities. Brain. 117:1994;1385-1393.
10. Latov N. Waldenström's Macroglobulinemia and nonmalignant IgM monoclonal gammopathies. Kelly J.J., Kyle R.A., Latov N. Polyneuropathies associated with plasma cell discrasia. 1987;51-72 Martinus Nijhoff Publishing, Boston.
11. Nobile-Orazio E., Manfredini E., Carpo M., Meucci N., Monaco S., Ferrari S., Bonetti B., Cavaletti G., Gemignani F., Durelli L., Barbieri S., Allaria S., Sgarzi M., Scarlato G. Frequency and clinical correlates of anti-neural IgM antibodies in neuropathy associated with IgM monoclonal gammopathy. Ann Neurol. 36:1994;416-424.
12. Latov N. Nonmalignant IgG and IgA gammopathies. Kelly J.J., Kyle R.A., Latov N. Polyneuropathies associated with plasma cell discrasia. 1987;73-76 Martinus Nijhoff Publishing, Boston.
13. Thomas P.K., Willison H.J. Paraproteinemic neuropathy. Baillière Clin Neur. 3:1994;129-147.
14. Vallat J.M., Jauberteau M.O., Bordessoule D., Yardin C., Preux P.M., Couratier P. Link between peripheral neuropathy and monoclonal dysglobulinemia: a study of 66 cases. J Neurol Sci. 137:1996;124-130.
15. Kyle R.A. Plasma cell dyscrasia: definition and diagnostic evaluation. Kelly J.J., Kyle R.A., Latov N. Polyneuropathies associated with plasma cell discrasia. 1987;1-28 Martinus Nijhoff Publishing, Boston.
16. Kelly J.J. The electrodiagnostic findings in peripheral neuropathy associated with monoclonal gammopathy. Muscle Nerve. 6:1983;504-509.
17. Nobile-Orazio E., Marmiroli P., Baldini L., Spagnol G., Barbieri S., Moggio M., Polli N., Polli E., Scarlato G. Peripheral neuropathy in macroglobulinemia: incidence and antigen specificity of M-proteins. Neurology. 37:1987;1506-1514.
18. Dyck P.J., Karnes J., Lais A., Lofgren E.P., Stevens J.K. Pathologic alteration of the peripheral nervous system of humans. Dyck P.J., Thomas P.K., Lambert E.H., Bunge R. Peripheral neuropathy. 2nd ed :1984;760-870 WB Saunders, Philadelphia.
19. Takatsu M., Hays A.P., Latov N., Abrams G.M., Sherman W.H., Nemni R., Nobile-Orazio E., Saito T., Freddo L. Immunofluorescence study of patients with neuropathy and IgM M-proteins. Ann Neurol. 18:1985;173-181.
20. Nobile-Orazio E., Manfredini E., Sgarzi M., Spagnol G., Allaria S., Quattroni M., Scarlato G. Serum IgG antibodies to a 35-Kda PO-related glycoprotein in motor neuron disease. J Neuroimmunol. 53:1994;143-151.
21. Carpo M., Nobile-Orazio E., Meucci N., Gamba M., Barbieri S., Allaria S., Scarlato G. Anti-GD1a Ganglioside antibodies in peripheral motor syndromes. Ann Neurol. 39:1996;539-543.
22. Tettamanti G., Bonali F., Marchesini S., Zambotti V. A new procedure for the extraction, purification and fractionation of brain gangliosides. Biochim Biophys Acta. 296:1973;160-170.
23. Hermosilla E., Lagueny A., Vital C., Vital A., Ferrer X., Steck A., Julien J. Peripheral neuropathy associated with monoclonal IgG of undetermined significance: clinical, electrophysiologic, pathologic and therapeutic study of 14 cases. J Periph Nerv Syst. 1:1996;139-148.
24. Gorson K.C., Ropper A.H. Axonal neuropathy associated with monoclonal gammopathy of undetermined significance. J Neurol Neurosurg Psychiatry. 63:1997;163-168.
25. Research criteria for diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP). Neurology. 41:1991;617-618.
26. Bromberg M.B., Feldman E.L., Albers J.W. Chronic inflammatory demyelinating polyradiculoneuropathy: comparison of patients with and without an associated monoclonal gammopathy. Neurology. 42:1992;1157-1163.
27. Bleasel A.F., Hawke S.H.B., Pollard J.D., McLeod J.G. IgG monoclonal paraproteinaemia and peripheral neuropathy. J Neurol Neurosurg Psychiatry. 56:1993;52-57.
28. Simmons Z., Albers J.W., Bromberg M.B., Feldman E.L. Presentation and initial clinical course in patients with chronic inflammatory demyelinating polyradiculoneuropathy: comparison of patients without and with monoclonal gammopathy. Neurology. 43:1993;2202-2209.
29. Simmons Z., Albers J.W., Bromberg M.B., Feldman E.L. Long-term follow-up of patients with chronic inflammatory demyelinating polyradiculoneuropathy, without and with monoclonal gammopathy. Brain. 118:1995;359-368.
30. Connolly A.M., Pestronk A., Trotter J.L., Feldman E.L., Cornblath D.R., Olney R.K. High titer selective serum anti-beta-tubulin antibodies in chronic inflammatory demyelinating polyneuropathy. Neurology. 43:1993;557-562.
31. Manfredini E., Nobile-Orazio E., Allaria S., Scarlato G. Anti-alpha- and beta-tubulin IgM antibodies in dysimmune neuropathies. J Neurol Sci. 133:1995;79-84.
32. Van Schaik I.N., Vermeulen M., Van Doorn P.A., Brand A. Anti-beta-tubulin antibodies have no diagnostic value in patients with chronic inflammatory demyelinating polyneuropathy. J Neurol. 242:1995;599-603.
33. Yuki N., Tagawa Y., Handa S. Autoantibodies to peripheral nerve glycosphingolipids SPG, SLPG and SGPG in Guillain Barré syndrome and chronic inflammatory demyelinating polyneuropathy. J Neuroimmunol. 70:1996;1-6.
34. Fazio R., Nemni R., Quattrini A., Lorenzetti I., Canal N. IgG monoclonal proteins from patients with axonal peripheral neuropathies bind to different epitopes of the 68 kDa neurofilament protein. J Neuroimmunol. 36:1992;97-104.
35. Notermans N.C., Wokke J.H.J., Van den Berg L.H., Van der Graff Y., Franssen H., Teunissen L.L., Lokhorst H.M. Chronic idiopathic axonal polyneuropathy. Comparison of patients with and without monoclonal gammopathy. Brain. 119:1996;421-427.
36. Ritzmann S.E., Loukas D., Sakai H., Daniels J.C., Levin W.C. Idiopathic (asymptomatic) monoclonal gammopathies. Arch Intern Med. 135:1995;95-106.
37. Briani C., Berger J.S., Latov N. Antibodies to chondroitin sulfate C: a new detection assay and correlations with neurological diseases. J Neuroimmunol. 84:1998;117-121.
38. Sherman W.H., Latov N., Hays A.P., Takatsu M., Nemni R., Galassi G., Ossermann E.F. Monoclonal IgM-k antibody precipitating with chondroitin sulfate C from patients with axonal polyneuropathy and epidermolysis. Neurology. 33:1983;192-201.
39. Yee W.C., Hahn A.F., Hearn S.A., Rupar A.R. Neuropathy in IgMλ paraproteinemia. Immunoreactivity to neural proteins and chondroitin sulfate. Acta Neuropathol. 78:1989;57-64.
40. Quattrini A., Nemni R., Fazio R., Iannaccone S., Lorenzetti I., Grassi F., Canal N. Axonal neuropathy in a patient with monoclonal IgM kappa reactive with Schmidt-Lantermann incisures. J Neuroimmunol. 33:1991;73-79.
41. Mamoli A., Nemni R., Camerlingo M., Quattrini A., Corbo L., Lorenzetti I., Canal N. A clinical, electrophysiological, morphological and immunological study of chronic sensory neuropathy with ataxia and paresthesia. Acta Neurol Scand. 85:1992;110-115.
42. Nemni R., Fazio R., Quattrini A., Lorenzetti I., Mamoli D., Canal N. Antibodies to sulfatide and to chondroitin sulfate C in patients with chronic sensory neuropathy. J Neuroimmunol. 43:1993;79-86.
43. Dyck P.J., Low P.A., Windebank A.J., Jared S.S., Gosselin S., Bourque P., Smith B.E., Kratz K.M., Karnes J.L., Evans B.A., Pineda A.A., O'Brien P.C., Kyle R.A. Plasma exchange in polyneuropathy associated with monoclonal gammopathy of undetermined significance. N Engl J Med. 325:1991;1482-1486.
44. Notermans N.C., Lokhorst H.M., Franssen H., Van der Graaf Y., Teunissen L.L., Jennekens F.G.I., Van den Berg L.H., Wokke J.H.J. Intermittent cyclophosphamide and prednisone treatment of polyneuropathy associated with monoclonal gammopathy of undetermined significance. Neurology. 47:1996;1227-1233.
45. Contamin F., Singer B., Mignot B., Ecoffet M., Kazatchkine M. Polyneuropathie a rechutes évoluant dupuis 19 ans, associée a une gammapathie monoclonale IgG bénigne Effect favorable de la corticothérapie. Rev Neurol. 132:1976;741-762.
46. Read D.J., Vanhegan R.I., Matthews W.B. Peripheral neuropathy and benign IgG paraproteinaemia. J Neurol Neurosurg Psychiatry. 41:1978;215-219.
47. Noring L., Kjellin K.G., Siden A. Neuropathies associated with disorders of plasmocytes. Europ Neurol. 19:1980;224-230.
48. Ohnishi A., Hirano A. Uncompacted myelin lamellae in dysglobulinemic neuropathy. J Neurol Sci. 51:1981;131-140.
49. Dalakas M.C., Engel W.K. Polyneuropathy with monoclonal Gammopathy: Studies of 11 Patients. Ann Neurol. 10:1981;45-52.
50. Sewell H.F., Matthews J.B., Gooch E., Millac P., Willox A., Stern M.A., Walker F. Autoantibody to nerve tissue in a patient with a peripheral neuropathy and IgG paraproteinemia. J Clin Pathol. 34:1981;1163-1166.
51. Bosch P., Ansbacher L., Goeken J., Cancilla P. Peripheral neuropathy associated with monoclonal gammopathy. Studies of intraneural injections of monoclonal immunoglobulin sera. J Neuropathol Exp Neurol. 41:1982;446-459.
52. Fineman S.M., McKendall R.R. Plasma exchange: a treatment for neuropathy associated with IgG-kappa gammopathy. J Neurol. 237:1990;85-87.
53. Waterston J.A., Brown M.M., Ingram D.A., Swash M. Cyclosporin A therapy in paraprotein-associated neuropathy. Muscle Nerve. 15:1992;445-448.
54. Moorhouse D.F., Fox R.I., Powell H.C. Immunotactoid-like endoneurial deposits in a patient with monoclonal gammopathy of undetermined significance and neuropathy. Acta Neuropathol. 84:1992;484-494.