Bcl-2 and Bax protein expression in human myopathies

Journal of the Neurological Sciences

Volumn 164, Issue 1, 1999, Pages 76-81

  Olive M ^a   Ferrer, I ^b  

^a HOSPITAL CLÍNIC   (Spain)

^b Hospitalet   (Spain)

Author keywords

Apoptosis; Bax; Bcl 2; Inclusion body myositis; Muscular dystrophy; Necrosis; Necrotizing myopathy; Polymyositis; Regeneration

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2;

ADOLESCENT; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MUSCLE BIOPSY; MUSCLE CELL; MUSCLE DISEASE; MUSCLE NECROSIS; MUSCLE REGENERATION; MYOPATHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTO ONCOGENE; RECEPTOR UPREGULATION; SARCOLEMMA;

ADOLESCENT; ADULT; AGED; BCL-2-ASSOCIATED X PROTEIN; BIOPSY; DNA FRAGMENTATION; FEMALE; HUMANS; MALE; MIDDLE AGED; MUSCLE, SKELETAL; MUSCULAR DISEASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0033560020     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(99)00041-6     Document Type: Article

References (33)

1. Wyllie A.H., Kerr J.R.F., Currie A.R. Cell death: the significance of apoptosis. Int Rev Cytol. 68:1990;251-356.
2. Kerr J.F.R., Harmon B.V. Definition and incidence of apoptosis: an historical perspective. Tomei L.D., Cope F.O. Apoptosis: The molecular basis of cell death. 1991;1-29 Cold Spring Harbor Laboratory Press, New York.
3. Wyllie A.H. The genetic regulation of apoptosis. Curr Op Gen Develop. 5:1995;97-104.
4. Webb J.N. The development of human skeletal muscle with particular reference to cell death. J Path. 106:1971;221-228.
5. Webb J.N. Cell death in developing skeletal muscle: histochemistry and ultrastructure. J Path. 123:1977;175-180.
6. Fidzianska A., Goebel H.H. Human ontogenesis. Cell death in fetal muscle. Acta Neuropathol. 81:1990;572-577.
7. Olivé M., Blanco R., Rivera R., Cinós C., Ferrer I. Gamma-ray-induced cell death in developing skeletal muscle. J Anat. 187:1995;127-132.
8. Carraro U. Apoptotic death of dystrophic muscle fibers after exercise: A new hypothesis on the early events of muscle damage. Basic Appl Myol. 5:1995;371-374.
9. Podhorska-Olokov M., Sandri M., Bruson A., Carraro U., Massimino M.L., Arslan P., et al. Apoptotic myonuclei appear in adult skeletal muscles of normal and mdx mice after mild exercise. Basic Appl Myol. 5:1995;87-90.
10. Tidball J.G., Albrecht D.E., Lokensgard B.E., Spencer M.J. Apoptosis precedes necrosis of dystrophin-deficient muscle. J Cell Sci. 108:1995;2197-2204.
11. Sandri M., Podhorska-Olokow M., Geromel V., Rizzi C., Arslan P., Franceschi C., et al. Exercise induces myonuclear ubiquitination and apoptosis in dystrophin-deficient muscle of mice. J Neuropathol Exp Neurol. 56:1997;45-57.
12. Fidzianska A., Goebel H.H., Warlo I. Acute infantile spinal atrophy. Muscle apoptosis as a proposed pathogenetic mechanism. Brain. 113:1990;433-445.
13. Tews D.S., Goebel H.H. Apoptosis-related proteins in skeletal muscle fibers of Spinal Muscular Atrophy. J Neuropathol Exp Neurol. 56:1997;150-156.
14. Tews D.S., Goebel H.H. DNA-fragmentation and expression of apoptosis-related proteins in muscular dystrophies. Neuropathol Appl Neurobiol. 23:1997;331-338.
15. Schneider C., Gold R., Dalakas M., Schmied M., Lassmann H., Toyka K.V., et al. MHC class I-mediated cytotoxicity does not induce apoptosis in muscle fibers nor in inflammatory T cells: studies in patients with polymyositis, dermatomyositis and inclusion body myositis. J Neuropathol Exp Neurol. 55:1996;1205-1209.
16. Behrens L., Bender A., Johnson M.A., Hohlfeld R. Cytotoxic mechanisms in inflammatory myopathies. Co-expression of Fas and protective Bcl-2 in muscle fibres and inflammatory cells. Brain. 120:1997;929-938.
17. Inukai A., Kobayashi Y., Ito K., Doyu M., Takano A., Honda H., et al. Expression of Fas antigen is not associated with apoptosis in human myopathies. Muscle and Nerve. 20:1997;702-709.
18. Olivé M., Mtnez-Matos J.A., Montero J., Ferrer I. Apoptosis is not the mechanism of cell death of muscle fibers in human muscular dystrophies and inflammatory myopathies. Muscle and Nerve. 20:1997;1328-1330.
19. Hockenberry D., Nuñez G., Milliman C., Schreiber R.D., Korsmeyer S.J. Bcl-2 is a inner mitochondrial membrane protein that blocks programmed cell death. Nature. 348:1990;334-336.
20. Hockenberry D., Oltvai Z.N., Yin X.-M., Milliman C.L., Korsmeyer S.J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell. 75:1993;241-251.
21. Oltvai Z.N., Milliman C.L., Korsmeyer J. Bcl-2 heterodimerized in vivo with a conserved homolog; Bax, that accelerates programmed cell death. Cell. 74:1993;609-619.
22. Craig R.W. The bcl-2 gene family. Semin Cancer Biol. 6:1995;35-43.
23. Davies J.C. The Bcl-2 family of proteins, and the regulation of cell survival. Trends Neurol Sci. 18:1995;355-358.
24. Sedlak T.W., Oltvai Z.N., Yang E., Wang K., Boise L.H., Thompson C.B., et al. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci USA. 92:1995;7834-7838.
25. Merry D.E., Korsmeyer S.J. Bcl-2 gene family in the nervous system. Ann Rev Neurosci. 20:1997;245-267.
26. Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labelling of DNA nuclear fragmentation. J Cell Biol. 119:1992;493-501.
27. Oldfors A., Larsson N.-G., Lindberg C., Holme E. Mitochondrial DNA deletions in inclusion body myositis. Brain. 116:1993;325-336.
28. Santorelli F.M., Sciacco M., Tanji K., Shanske S., Vu T.H., Golzi V., et al. Multiple mitochondrial DNA deletions in sporadic inclusion body myositis: a study of 56 patients. Ann Neurol. 39:1996;789-795.
29. Krajewski S., Tanaka S., Takayama S., Schibler M.J., Fenton W., Reed J.C. Investigation of the subcellular distribution of the Bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 53:1993;743-753.
30. Chen J., Graham S.H., Chan P.H., Lan J., Zhou R.L., Simon R.P. Bcl-2 is expressed in neurons that survive focal ischemia in the rat. Neuroreport. 6:1995;394-398.
31. Ferrer I., Pozas E., Lopez E., Ballabriga J. Bcl-2, Bax and Bcl-x expression following hypoxia-ischemia in the infant rat brain. Acta Neuropathol. 94:1997;583-589.
32. Ferrer I., Tortosa A., Condom E., Blanco R., Macaya A. Increased expression of Bcl-2 immunoreactivity in the cerebral cortex of the rat. Neurosci Lett. 179:1994;13-16.
33. Brown R.H. Free radicals, programmed cell death and muscular dystrophy. Curr Opin Neurol. 8:1995;373-378.