Vascularization of human glioma spheroids implanted into rat cortex is conferred by two distinct mechanisms

Journal of Neuroscience Research

Volumn 55, Issue 4, 1999, Pages 486-495

  Goldbrunner, Roland H ^c   Bernstein, Jerald J ^a,b   Plate, Karl H ^d   Vince, Giles H ^d   Roosen, Klaus ^d   Tonn, Joerg Christian ^d  

^a DEPARTMENT OF VETERANS AFFAIRS   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d NONE

Author keywords

Angiogenesis; Endothelial cell; Spheroid; Vascularization; VEGF

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; COLLAGENASE; EPIDERMAL GROWTH FACTOR; GANGLIOSIDE GD3; INTEGRIN; INTEGRIN RECEPTOR; MATRIX METALLOPROTEINASE; OSTEOPONTIN; PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR; THROMBIN; TRANSFORMING GROWTH FACTOR BETA; TYROSINE KINASE RECEPTOR; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL COUNT; CELL MIGRATION; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM CELL; GLIOBLASTOMA; GLIOMA; HYPOXIA; IMMUNOASSAY; METASTASIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SPHEROID CELL; TUMOR GROWTH; TUMOR VASCULARIZATION; VASCULARIZATION;

ANIMALS; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL MOVEMENT; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; GLIOMA; HUMANS; LYMPHOKINES; MALE; MICROSCOPY, CONFOCAL; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PIA MATER; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0033557976     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990215)55:4<486::AID-JNR8>3.0.CO;2-A     Document Type: Article

References (53)

1. Acker H, Carlsson J. 1992. The microenvironment in multicellular spheroids. In: Bjerkvig R, editor. Spheroid culture in cancer research. Boca Raton, FL: CRC Press. p 136-158.
2. Akslen LA, Andersen KJ, Bjerkvig R. 1988. Characteristics of human and rat glioma cells grown in a defined medium. Anticancer Res 8:797-804.
3. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. 1997. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964-967.
4. Bernstein JJ, Edvardsen K. 1997. Astrocytomas recruit endothelial cells (abstract). J Neuro-Oncol 35:10.
5. Bernstein JJ, Goldberg WJ, Laws ERJ. 1989. Human malignant astrocytoma xenografts migrate in rat brain: A model for central nervous system cancer research. J Neurosci Res 22:134-144.
6. Bjerkvig R, Lund-Johansen M, Edvardsen K. 1997. Tumor cell invasion and angiogenesis in the central nervous system. Curr Opin Oncol 9:223-229.
7. Clohisy DR, Ogilvie CM, Carpenter RJ, Ramnaraine ML. 1996. Localized, tumor-associated osteolysis involves the recruitment and activation of osteoclasts. J Orthop Res 14:2-6.
8. Damert A, Machein M, Breier G, Fujita MQ, Hanahan D, Risau W, Plate KH. 1997. Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia driven mechanisms. Cancer Res 57:3860-3864.
9. Dellian M, Witwer BP, Salehi HA, Yuan F, Jain RK. 1996. Quantitation and physiological characterization of angiogenic vessels in mice. Am J Pathol 149:59-71.
10. Desbaillets I, Diserens AC, Tribolet N, Hamou MF, Van Meir EG. 1997. Upregulation of interleukin 8 by oxygen deprived cells in glioblastomas suggests a role in leukocyte activation, chemotaxis, and angiogenesis. J Exp Med 186:1201-1212.
11. Farrel CL, Steward PA, Del Maestro RF. 1987. A new glioma model in rat: the C6 spheroid implantation technique permeability and vascular characterization. J Neurooncol 4:403-415.
12. Folkman J. 1972. Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg 175:409-416.
13. Folkman J. 1992. The role of angiogenesis in tumor growth. Semin Cancer Biol 3:65-71.
14. Folkman J. 1995. Diagnostic and therapeutic applications of angiogenesis research. CR Acad Sci III 316:909-918.
15. Gladson CL. 1996. Expression of integrin αvβ3 in small blood vessels of glioblastoma tumors. J Neuropath Exp Neurol 55:1143-1149.
16. Goldbrunner RH, Haugland HK, Klein CE, Roosen K, Tonn JC. 1996. ECM dependent and integrin mediated tumor cell migration of human glioma and melanoma cell lines under serum free conditions. Anticancer Res 16:3679-3688.
17. Gospodarowicz D, Bialecki H, Thrakal TK. 1979. The angiogenic activity of the fibroblast and epidermal growth factor. Exp Eye Res 28:501-515.
18. Hatva E, Kaipainen A, Mentula P, Jaaskelainen J, Paetau A, Haltia M, Alitalo K. 1995. Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors. Am J Pathol 146:368-378.
19. Kim JB, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N. 1993. Inhibition of vascular endothelial growth factor induced angiogenesis suppresses tumor growth in vivo. Nature 362:841-844.
20. Kleihues P, Burger PC, Scheithauer BW. 1993. The new WHO classification of brain tumors. Brain Pathol 3:255-268.
21. Koochekpour S, Merzak A, Pilkington GJ. 1996. Vascular endothelial growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells in vitro. Cancer Lett 102:209-215.
22. Kotitschke K, Tonn JC, Goldbrunner RH, Bogdahn U, Haase A. 1995. 1H-NMR spectroscopic investigations of tumor spheroids grown from a human glioma biopsy as well as from a pertinent human malignant glioma cell line. J Magn Reson 109:39-43.
23. Kremer C, Breier G, Risau W, Plate KH. 1997. Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system. Cancer Res 57:3852-3859.
24. Kumar R, Yoneda J, Bucana CD, Fidler IJ. 1998. Regulation of distinct steps of angiogenesis by different angiogenic molecules. Int J Oncol 12:749-757.
25. Lund-Johansen M, Engebraaten O, Bjerkvig R, Laerum OD. 1990. Invasive glioma cells in tissue culture. Anticancer Res 10:1135-1152.
26. McLeod DS, Lutty GA, Wajer SD, Flower RW. 1987. Visualization of a developing vasculature. Microvasc Res 33:257-269.
27. Millauer B, Shawer L, Plate KH, Risau W, Ullrich A. 1994. Glioblastoma growth inhibited in vivo by a dominant-negative flk-1 mutant. Nature (Lond.) 367:576-579.
28. 2 consumption of multicellular spheroids during development of necroses. Adv Exp Med Biol 191:775.
29. Nakagawa T, Kubota T, Kabuto M, Sato K, Kawano H, Hayakawa T, Okada Y. 1994. Production of matrix metalloproteinases and tissue inhibitor of metalloproteinases-1 by human brain tumors. J Neurosurg 81:69-77.
30. Nakayama Y, Sueishi K, Oka K, Kono S, Tomonaga M. 1998. Stromal angiogenesis in human glioma: a role of platelet derived endothelial cell growth factor. Surg Neurol 49:181-187.
31. Paulus W, Huettner C, Tonn JC. 1994. Collagens, integrins and the mesenchymal drift in glioblastomas: A comparison of biopsy specimens, spheroid and early monolayer cultures. Int J Cancer 58:841-846.
32. Pepper MS, Wasi S, Ferrara N, Orci L, Montessano R. 1994. In vitro augiogenic and proteolytic properties of bovine lymphatic endothelial cells. Exp Cell Res 210:298-305.
33. Plate KH, Breier G, Millauer B, Ullrich A, Risau W. 1993. Upregulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res 53:5822-5827.
34. Plate KH, Breier G, Risau W. 1994a. Molecular mechanisms of developmental and tumor angiogenesis. Brain Pathol 4:207-218.
35. Plate KH, Breier G, Weich HA, Mennel HD, Risau W. 1994b. Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer 59:520-529.
36. Plate KH, Breier G, Weich HA, Risau W. 1992. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature 359:845-848.
37. Rao JS, Yamamoto M, Mohanam S, Gokaslan ZL, Fuller GN, Stetler-Stevenson WG, Rao VH, Liotta LA, Nicolson GL, Sayawa RF. 1996. Expression and localization of 92 kDa type IV collagenase/gelatinase B (MMP-9) in human gliomas. Clin Exp Metastasis 14:12-18.
38. Risau W, Drexler H, Mironov V, Smits A, Siegbahn A, Funa K, Heldin C. 1992. Platelet derived growth factor is angiogenic in vivo. Growth Factors 7:261-266.
39. Russel DS, Rubinstein LJ. 1989. Pathology of tumors of the nervous system. London: Arnold. 223 p.
40. Saleh M, Stacker SA, Wilks AF. 1996. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence. Cancer Res 56:393-401.
41. Samoto K, Ikezaki K, Ono M, Shono T, Kohno K, Kuwano M, Fukui M. 1995. Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors. Cancer Res 55:1189-93.
42. Schreiber AB, Winkler ME, Derynck R. 1986. Transforming growth factor α: A more potent angiogenic mediator than epidermal growth factor. Science 232:1250-1253.
43. Segal DH, Germano IM, Bederson JB. 1997. Effects of basic fibroblast factor on in vivo cerebral tumorigenesis in rats. Neurosurgery 40:1027-1033.
44. Senger DR, Ledbetter SR, Claffey KP, Papadopoulos-Sergiou A, Peruzzi CA, Detmar M. 1996. Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the αvβ3 integrin, osteopontin, and thrombin. Am J Pathol 149:293-305.
45. Shweiki D, Neeman M, Itin A, Keshet E. 1995. Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis. Proc Natl Acad Sci USA 92:768-772.
46. Stein I, Neeman M, Shweiki D, Itin A, Keshet E. 1995. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol 15:5363-5368.
47. Takano S. Yoshii Y, Kondo S, Suzuki H, Maruno T, Shirai S, Nose T. 1996. Concentration of vascular endothelial growth factor in the serum and tumor tissue of brain tumor patients. Cancer Res 56:2185-2190.
48. Tonn JC, Haugland HK, Saraste J, Roosen K, Laerum OD. 1995. Differential effects of vincristine and phenytoin on the proliferation, migration, and invasion of human glioma cell lines. J Neurosurg 82:1035-1043.
49. Tooth HH. 1912. Some observations on the growth and survival-period of intracranial tumours, based on the records of 500 cases, with special reference to the pathology of the gliomata. Brain 35:61-108.
50. Tsai JC, Goldman CK, Gillespie GY. 1995. Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF. J Neurosurg 82:864-873.
51. Vince GH, Wagner S, Pietsch T, Goldbrunner RH, Bouterfa H, Roosen K, Tonn JC. 1997. Intratumoral heterogeneous exression of matrix-metalloproteinases in astrocytic tumors (abstract). Anticancer Res 17:4061.
52. Wesseling P, van der Laak JA, Link M, Teepen HL, Ruiter DJ. 1998. Quantitative analysis of microvascular changes in diffuse astrocytic neoplasms with increasing grade of malignancy. Hum Pathol 29:352-358.
53. Yuan F, Salehi HA, Boucher Y, Vasthare US, Tuma RF, Jain RK. 1994. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res 54:4564-4568.