The tricarboxylic acid cycle of Helicobacter pylori

European Journal of Biochemistry

Volumn 260, Issue 1, 1999, Pages 258-267

  Pitson, Stuart M ^a   Mendz, George L ^a   Srinivasan, Sujatha ^a   Hazell, Stuart L ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Helicobacter pylori; Microaerophily; NMR; TCA cycle

Indexed keywords

ACONITATE HYDRATASE; CITRATE SYNTHASE; FUMARATE HYDRATASE; FUMARATE REDUCTASE; ISOCITRATE DEHYDROGENASE; MALATE DEHYDROGENASE; MALATE SYNTHASE; OXOGLUTARATE DEHYDROGENASE; TRICARBOXYLIC ACID;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; CITRIC ACID CYCLE; ENZYME ACTIVITY; ENZYME MECHANISM; HELICOBACTER PYLORI; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL;

ALLOSTERIC REGULATION; CITRIC ACID CYCLE; COENZYME A; GENOME, BACTERIAL; GLYOXYLATES; HELICOBACTER PYLORI; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; SUCCINIC ACID;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

EID: 0033557810     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00153.x     Document Type: Article

References (73)

1. Talley, N.J. & Noack, K.B. (1993) The worldwide prevalence of Helicobacter priori: asymptomatic infection and clinical states associated with infection in adults. In Helicobacter pylori: Biology and Clinical Practice (Goodwin, C.S. & Worsley, B.W., eds), pp. 63-83. CRC Press, Boca Raton.
2. Marshall, B.J. & Warren, J.R. (1984) Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet i, 1311-1315.
3. Morris, A. & Nicholson, G. (1987) Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. Am. J. Gatroenterol. 82, 192-199.
4. Lee, A., Fox, J. & Hazell, S. (1993) Pathogenicity of Helicobacter pylori: a perspective. Infect. Immun. 61, 1601-1610.
5. Parsonnet, J., Friedman, G.D., Vandersteen, D.P., Chang, Y., Vogelman, J.H., Orentreich, N. & Sibbley, R.K. (1991) Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med. 325, 1127-1131.
6. Nomura, A., Stemmermann, G.N., Chyou, P.H., Kato, I., Perez-Perez, G.I. & Blaser, M.J. (1991) Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N. Engl. J. Med. 325, 1132-1136.
7. Vanzanten, S.J.O.V. & Sherman, P.M. (1994) Helicobacter pylori infection as a cause of gastritis, duodenal ulcer, gastric cancer and non-ulcer dyspepsia - a systematic review. Can. Med. Assoc. J. 150, 177-185.
8. Goodwin, C.S. & Worsley, B.W. (1993) The Helicobacter genus: the history of H. pylori and taxonomy of current species. In Helicobacter pylori: Biology and Clinical Practice (Goodwin, C.S. & Worsley, B.W., eds), pp. 1-13. CRC Press, Boca Raton.
9. Tomb, J.-F., White, O., Kerlavage, A.R., Clayton, R.A., Sutton, G.G., Fleischmann, R.D., Ketchum, K.A., Klenk, H.P., Gill, S., Dougherty, B.A., Nelson, K., Quackenbush, J., Zhou, L., Kirkness, E.F., Peterson, S., Loftus, B., Richardson, D., Dodson, R., Khalak, H.G., Glodek, A., McKenney, K., Fitzegerald, L.M., Lee, N., Adams, M.D., Hickey, E.K., Berg, D.E., Gocayne, J.D., Utterback, T.R., Peterson, J.D., Kelley, J.M., Cotton, M.D., Weidman, J.M., Fujii, C., Bowman, C., Watthey, L., Wallin, E., Hayes, W.S., Borodovsky, M., Karp, P.D., Smith, H.O., Fraser, C.M. & Venter, J.C. (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388, 539-547.
10. Hazell, S.L. & Mendz, G.L. (1997) How Helicobacter pylori works: an overview of the metabolism of Helicobacter pylori. Helicobacter 2, 1-12.
11. Mendz, G.L. & Hazell, S.L. (1991) Evidence for a pentose phosphate pathway in Helicobacter pylori. FEMS Microbiol. Lett. 84, 331-336.
12. Mendz, G.L. & Hazell, S.L. (1993) Glucose phosphorylation in Helicobacter pylori. Arch. Biochem. Biophys. 300, 522-525.
13. Mendz, G.L., Hazell, S.L. & Burns, B.P. (1993) Glucose utilization and lactate production by Helicobacter pylori. J. Gen. Microbiol. 139, 3023-3028.
14. Mendz, G.L., Hazell, S.L. & Burns, B.P. (1994) The Entner-Doudoroff pathway in Helicobacter pylori. Arch. Biochem. Biophys. 312, 349-356.
15. Mendz, G.L. & Hazell, S.L. (1993) Fumarate catabolism in Helicobacter pylori. Biochem. Mol. Biol. Int. 31, 325-332.
16. Mendz, G.L., Hazell, S.L. & van Gorkom, L. (1994) Pyruvate metabolism in Helicobacter pylori. Arch. Microbiol. 162, 187-194.
17. Hughes, N.J., Chalk, P.A., Clayton, C.L. & Kelly, D.L. (1995) Identification of carboxylation enzymes and characterization of a novel four-subunit pyruvate: flavodoxin oxidoreductase from Helicobacter pylori. J. Bacteriol. 177, 3953-3959.
18. Mendz, G.L., Hazell, S.L. & Srinivasan, S. (1995) Fumarate reductase: a target for therapeutic intervention against Helicobacter pylori. Arch. Biochem. Biophys. 321, 153-159.
19. Mendz, G.L., Jimenez, B.M., Hazell, S.L., Gero, A.M. & O'Sullivan, W.J. (1994) De novo synthesis of pyrimidine nucleotides by Helicobacter pylori. J. Appl. Bacteriol. 77, 1-8.
20. Mendz, G.L., Jimenez, B.M., Hazell, S.L., Gero, A.M. & O'Sullivan, W.J. (1994) Salvage synthesis of purine nucleotides by Helicobacter pylori. J. Appl. Bacteriol. 77, 674-681.
21. Mendz, G.L. & Hazell, S.L. (1996) The urea cycle of Helicobacter pylori. Microbiology 142, 2959-2967.
22. Hazell, S.L., Evans, D.J. & Graham, D.Y. (1991) Helicobacter pylori catalase. J. Gen. Microbiol. 137, 57-61.
23. Mendz, G.L. & Hazell, S.L. (1995) Aminoacid utilization by Helicobacter pylori. Int. J. Biochem. Cell Biol. 27, 1085-1093.
24. 2 for growth. Microbiology 141, 3113-3118.
25. Corthesy-Theulaz, I.E., Bergonzelli, G.E., Henry, H., Bachmann, D., Schorderet, D.F., Blum, A.L. & Ornston, L.N. (1997) Cloning and characterization of Helicobacter pylori succinyl CoA: acetoacetate CoA-transferase, a novel prokaryotic member of the CoA-transferase family. J. Biol. Chem. 272, 25659-25667.
26. Clayton, C.L., Tay, A., O'Donnell, C. & Chalk, P.A. (1995) Elucidation of Helicobacter pylori metabolism by random genome sequencing. Gut 37, A67.
27. Hoffman, P.S., Goodwin, A., Johnsen, J., Magee, K. & Veldhuyzen van Zanten, S.J.O. (1996) Metabolic activities of metronidazole-sensitive and -resistant strains of Helicobacter pylori: repression of pyruvate oxidoreductase and expression of isocitrate lyase activity correlate with resistance. J. Bacteriol. 178, 4822-4829.
28. Guest, J.R. (1995) Adaptation to life without oxygen. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 350, 189-202.
29. Beacham, A.M., Seviour, R.J. & Lindrea, K.C. (1992) Polyphosphate accumulating abilities of Acinetobacter isolates from a biological nutrient removal pilot plant. Water Res. 26, 121-122.
30. Sambrook, J., Fritsch, E.F. & Maniatis, T. (1989) Molecular cloning. A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
31. Weitzman, P.D. (1987) Patterns of diversity of citric acid cycle enzymes. Biochem. Soc. Symposium 54, 33-43.
32. Reeves, H.C., Rabin, R., Wegener, W.S. & Ajl, S.J. (1971) Assays of enzymes of the tricarboxylic acid and glyoxylate cycles. Methods Microbiol. 6A, 425-462.
33. Veeger, C., Der Vartanian, D.V. & Zeylemaker, W.P. (1969) Succinate dehydrogenase. Methods Enzymol. 13, 81-90.
34. Bridger, W.A., Ramaley, R.F. & Boyer, P.D. (1969) Succinyl coenzyme A synthetase from Escherichia coli. Methods Enzymol. 13, 70-75.
35. Bergmeyer, H.U. & Bernt, E. (1983) Malate dehydrogenase. In Methods of Enzymatic Analysis, Vol, 3 (Bergmeyer, H.U., Bergmeyer, J. & Grassl, M., eds.), pp. 163-176. Verlag Chemie, Weinheim.
36. Altschul, S.F., Gish, W., Miller, W., Meyer, E.W. & Lipman, D.J. (1990) Basic local alignment search tool. J. Mol. Biol. 215, 403-410.
37. Needleman, S.B. & Wunsch, C.D. (1970) A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol. 48, 443-453.
38. Srere, P.A. (1969) Citrate synthase. Methods Enzymol. 13, 3-11.
39. Jorgensen, M.A., Mendz, G.L. & Hazell, S.L. (1997) Metronidazole resistance in H. pylori and reduction of 5,5′-dithiobis-(2-nitrobenzoic acid). Gut 41, A91.
40. Weitzman, P.D. (1981) Unity and diversity in some bacterial citric acid-cycle enzymes. Adv. Microb. Physiol. 22, 185-224.
41. Holms, W.H. (1987) Control of flux through the citric acid cycle and the glyoxytate bypass in Escherichia coli. Biochem. Soc. Symposium 54, 17-31.
42. Nimmo, H.G., Borthwick, A.C., El-Mansi, E.M.T., Holms, W.H., MacKintosh, C. & Nimmo, G.A. (1987) Regulation of the enzymes at the branchpoint between the citric acid cycle and the glyoxylate bypass in Escherichia coli. Biochem. Soc. Symposium 54, 93-101.
43. Dawson, R.M.C., Elliot, D.C., Elliot, W.H. & Jones, K.M. (1986) Data for Biochemical Research, Clarendon Press, Oxford.
44. Kröger, A., Geisler, V., Lemma, E., Theis, F. & Lenger, R. (1992) Bacterial fumarate respiration. Arch. Microbiol. 158, 311-314.
45. Remington, S., Weigand, G. & Huber, R. (1982) Crystallographic refinement and atomic models of two different forms of citrate synthase at 2.7 and 1.7 Å resolution. J. Mol. Biol. 158, 111-152.
46. Weigand, G. & Remington, S.J. (1986) Citrate synthase: structure, control, and mechanism. Annu. Rev. Biophys. Biophys. Chem. 15, 97-117.
47. Anderson, D.H. & Duckworth, H.W. (1988) In-vitro mutagenesis of Escherichia coli citrate synthase to clarify the location of ligand binding sites. J. Biol. Chem. 263, 2163-2169.
48. Wood, D.O., Williamson, L.R., Winkler, H.H. & Krause, D.C. (1987) Nucleotide sequence of the Rickettsia prowazekii citrate synthase gene. J. Bacteriol. 169, 3564-3572.
49. Duckworth, H.W., Anderson, D.H., Bell, A.W., Donald, L.J., Chu, A.L. & Brayer, G.D. (1987) Structural basis for regulation in gram-negative bacterial citrate synthases. Biochem. Soc. Symposium 54, 83-92.
50. Greet, M.J., Artymiuk, P.J. & Guest, J.R. (1997) The aconitase family: three structural variations on a common theme. Trends Biochem. Sci. 22, 3-6.
51. Bradbury, A.J., Gruer, M.J., Rudd, K.E. & Guest, J.R. (1996) The second aconitase (AcnB) of Escherichia coli. Microbiology 142, 389-400.
52. Hurley, J.H., Thorsness, P.E., Ramalingam, V., Helmers, N.H., Koshland, D.E., Jnr. & Stroud, R.M. (1989) Structure of a bacterial enzyme regulated by phosphorylation, isocitrate dehydrogenase. Proc. Natl Acad. Sci. USA 86, 8635-8639.
53. + complexes. Biochemistry 30, 8671-8678.
54. Borthwick, A.C., Holms, W.H. & Nimmo, H.G. (1984) Amino acid sequence round the site of phosphorylation in isocitrate dehydrogenase from Escherichia coli, ML308. FEBS Lett. 174, 112-115.
55. Thorsness, P.E. & Koshland, D.E., Jnr. (1987) Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate. J. Biol. Chem. 262, 10422-10425.
56. Dean, A.M. & Golding, G.B. (1997) Protein engineering reveals ancient adaptive replacements in isocitrate dehydrogenase. Proc. Natl Acad. Sci. USA 94, 3104-3109.
57. Simpson, A., Bateman, O., Driessen, H., Lindley, P., Moss, D., Mylvaganam, S., Nambor, E. & Slingsby, C. (1994) The structure of avian eye lens delta-crystallin reveals a new fold for a superfamily of oligomeric enzymes. Nat. Struct. Biol. 1, 724-734.
58. Weaver, T. & Banaszak, L. (1996) Crystallographic studies of the catalytic and a second site in fumarase C from Escherichia coli. Biochemistry 35, 13955-13965.
59. Weaver, T., Lees, M. & Banaszak, L. (1997) Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site. Prot. Sci. 6, 834-842.
60. Goodwin, C.S., Armstrong, J.A., Chilvers, T., Peters, M., Collins, M.D., Sly, L., McConnell, W. & Harper, W.E.S. (1989) Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen. nov. as Helicobacter pylori comb. nov. & Helicobacter mustelae comb. nov., respectively. Int. J. Syst. Bacteriol. 39, 397-405.
61. Lauterbach, F., Körtner, C., Albracht, S.P.J., Unden, G. & Kröger, A. (1990) The fumarate reductase operon of Wolinella succinogenes. Sequence and expression of the frdA and frdB genes. Arch. Microbiol. 154, 386-393.
62. Cronin, J.E. & LaPorte, D. (1996) Tricarboxylic acid cycle and glyoxylate bypass. In Escherichia coli and Salmonella typhimurium. Cellular and Molecular Biology (Neidhardt, F.C., Curtiss, R., Ingraham, J.L., Lin, E.C.C., Low, K.B., Magasanik, B., Reznikoff, W.S., Riley, M., Schaechter, M. & Umbarger, H.E., eds), pp. 206-216. ASM Press, Washington.
63. Smith, A.J. & Hoare, D.S. (1977) Specialist phototrophs, lithotrophs, and methylotrophs: a unity among a diversity of procaryotes? Bacteriol. Rev. 41, 419-448.
64. 4-metabolism in free-living and bacteroid forms of Rhizobium leguminosarum. J. Gen. Microbiol. 134, 1433-1440.
65. Green, L.S. & Emerich, D.W. (1997) Bradyrhizobium japonicum does not require α-ketoglutarate dehydrogenase for growth on succinate or malate. J. Bacteriol. 179, 194-201.
66. Sievers, M., Stockli, M. & Teuber, M. (1997) Purification and properties of citrate synthase from Acetobacter europaeus. FEMS Microbiol. Lett. 146, 53-58.
67. Phibbs, P.V. & Winkler, H.H. (1982) Regulatory properties of citrate synthase from Rickettsia prowazekii. J. Bacteriol. 149, 718-725.
68. Donald, L.J., Molgat, G.F. & Duckworth, H.W. (1989) Cloning, sequencing, and expression of the gene for NADH-sensitive citrate synthase of Pseudomonas aeruginosa. J. Bacteriol. 171, 5542-5550.
69. Gruer, M.J. & Guest, J.R. (1994) Two genetically-distinct and differentially-regulated aconitases (AcnA and AcnB) in Escherichia coli. Microbiology 140, 2531-2541.
70. Perham, R.N., Packman, L.C. & Radford, S.E. (1987) 2-Oxo acid dehydrogenase multi-enzyme complexes: in the beginning and halfway there. Biochem. Soc. Symposium 54, 67-81.
71. Mai, X. & Adams, M.W.W. (1996) Purification and characterization of two reversible and ADP-dependent acetyl coenzyme A synthetases from the hyperthermophilic archaeon Pyrococcus furiosus. J. Bacteriol. 178, 5890-5896.
72. Pickett, M.W., Williamson, M.P. & Kelly, D.J. (1994) An enzyme and C-13-NMR study of carbon metabolism in Heliobacteria. Photosynth. Res. 41, 75-88.
73. Allison, M.J., Robinson, I.M. & Baetz, A.L. (1979) Synthesis of α-ketoglutarate by reductive carboxylation of succinate in Veillonella, Selenomonas, and Bacteroides species. J. Bacteriol. 140, 980-986.