A human immunoglobulin (Ig)A Cα3 domain motif directs polymeric Ig receptor-mediated secretion

Journal of Experimental Medicine

Volumn 189, Issue 4, 1999, Pages 747-751

  Hexham, J Mark ^a,b   White, Kendra D ^a   Carayannopoulos, Leonidas N ^a,c   Mandecki, Wlodeck ^a,d   Brisette, Renee ^a,d   Yang, Yih Sheng ^a,e   Capra, J Donald ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d DGI BioTechnologies   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Immunoglobulin A; J chain; Mucosal immunity; Polymeric immunoglobulin receptor; Secretory immunoglobulin A

Indexed keywords

ALANINE; AMINO ACID; ANTIBODY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN RECEPTOR; SECRETORY IMMUNOGLOBULIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CELL STRAIN; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; MUCOSA; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DIMERIZATION; DOGS; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A, SECRETORY; IMMUNOGLOBULIN CONSTANT REGIONS; KIDNEY; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, POLYMERIC IMMUNOGLOBULIN; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033557167     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.189.4.747     Document Type: Article

References (31)

1. Underdown, B.J., and J.M. Schiff. 1986. Immunoglobulin A: strategic defense initiative at the mucosal surface. Annu. Rev. Immunol. 4:389-417.
2. Childers, N.K., M.G. Bruce, and J.R. McGhee. 1989. Molecular mechanisms of immunoglobulin A defense. Annu. Rev. Microbiol. 43:503-536.
3. Mostov, K.E., and G. Blobel. 1982. A transmembrane precursor of secretory component. The receptor for transcellular transport of polymeric immunoglobulins. J. Biol. Chem. 257: 11816-11821.
4. Koshland, M.E. 1985. The coming of age of the immunoglobulin J chain. Annu. Rev. Immunol. 3:425-453.
5. Putnam, F.W., Y.S.V. Liu, and T.L.K. Low. 1979. Primary structure of a human IgA1 immunoglobulin. J. Biol. Chem. 254:2865-2874.
6. Garcia-Pardo, A., M.E. Lamm, A.G. Plaut, and B. Frangione. 1981. J chain is covalently bound to both monomer subunits in human secretory IgA. J. Biol. Chem. 256:11734-11738.
7. Bastian, A., H. Kratzin, K. Eckart, and N. Hilschmann. 1992. Intra- and interchain disulfide bridges of the human J chain in secretory immunoglobulin A. Biol. Chem. Hoppe Seyler. 373:1255-1263.
8. Atkin, J.D., R.J. Pleass, R.J. Owens, and J.M. Woof. 1996. Mutagenesis of the IgA1 heavy chain tailpiece that prevents dimer assembly. J. Immunol. 157:156-159.
9. Krugman, S., R.J. Pleass, J.D. Atkin, and J.M. Woof. 1997. Structural requirements for assembly of dimeric IgA probed by site-directed mutagenesis of J chain and a cysteine residue of the alpha-chain CH2 domain. J. Immunol. 159:144-249.
10. Mostov, K.E., M. Freidlander, and G. Blobel. 1984. The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature. 308:37-43.
11. Lindh, E., and I. Bjork. 1974. Binding of secretory component to dimers of immunoglobulin A in vitro. Eur. J. Biochem. 45:261-268.
12. Fallgreen-Gebauer, E., W. Gebauer, A. Bastian, H.D. Kratzin, H. Eiffert, B. Zimmermann, M. Karas, and N. Hilschmann. 1993. The covalent linkage of secretory component to IgA. Biol. Chem. Hoppe Seyler. 374:1023-1028.
13. Underdown, B.J., J. De Rose, and A. Plaut. 1977. Disulfide bonding of secretory component to a single monomer sub-unit in human secretory IgA. J. Immunol. 118:1816-1821.
14. Frutiger, S., G.J. Hughes, W.C. Hanly, M. Kingzette, and J.C. Jaton. 1986. The amino terminal domain of rabbit secretory component is responsible for noncovalent binding to immunoglobulin A dimers. J. Biol. Chem. 261:16673-16681.
15. Bakos, M., A. Kurowsky, and R.M. Goldblum. 1991. Characterization of a critical binding site for human polymeric Ig on secretory component. J. Immunol. 147:3419-3426.
16. Carayannopoulos, L.N., E.E. Max, and J.D. Capra. 1994. Recombinant human IgA expressed in insect cells. Prof. Natl. Acad. Sci. USA. 91:8348-8352.
17. O'Reilly, D.R., L.K. Miller, and V.A. Luckow. 1992. Baculovirus Expression Vectors: A Laboratory Manual. W.H. Freeman and Co., New York. 347 pp.
18. Rindisbacher, L., S. Cottet, R. Witteek, and J.-P. Kraehenbuhl. 1995. Production of human secretory component with dimeric IgA binding capacity using viral expression systems. J. Biol. Chem. 270:14220-14228.
19. Horton, R.M., Z. Cai, S.N. Ho, and L.R. Pease. 1990. Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. Biotechniques. 8:528-535.
20. Ravera, M.W., J. Carcamo, R. Brissette, A. Alam-Moghe, O. Dedova, W. Cheng, K.C. Hsiao, D. Klebanov, H. Shen, P. Tang, et al. 1998. Identification of an allosteric binding site on the transcription factor p53 using a phage-displayed peptide library. Oncogene. 16:1993-1999.
21. Hexham, J.M. 1998. Production of human Fab antibody fragments from phage display libraries. Methods Mol. Biol. 80: 461-474.
22. Huang, X. 1994. On global sequence alignment. Comput. Appl. Biosci. 10:227-235.
23. Smith, R.F., and T.F. Smith. 1992. Pattern-induced multi-sequence alignment (PIMA) algorithm employing secondary structure-dependent gap penalties for use in comparative protein modelling. Protein Eng. 5:35-41.
24. Carayannopoulos, L.N., J.M. Hexham, and J.D. Capra. 1996. Localization of the binding site for the monocyte IgA-Fc receptor (CD89) to the domain boundary between Ca2 and Ca3 in human IgA1 J. Exp. Med. 183:1579-1586.
25. Mostov, K.E., and D.L. Deitcher. 1986. Polymeric immunoglobulin receptor expressed in MDCK cells transcytoses IgA. Cell. 46:613-621.
26. Cwirla, S., E. Peters, R. Barrett, and W. Dower. 1990. Peptides on phage: a vast library of peptides for identifying ligands. Proc. Natl. Acad. Sci. USA. 87:6378-6382.
27. Parmley, S., and G. Smith. 1988. Antibody-selectable filamentous fd phage vectors: affinity purification of target genes. Gene. 73:305-318.
28. Devlin, J., L. Panganiban, and P. Devlin. 1990. Random peptide libraries: a source for specific protein binding molecules. Science. 249:404-406.
29. Deisenhofer, J. 1981. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9 and 2.8 Angstroms resolution. Biochemistry. 20:2361-2370.
30. Hendrickson, B.A., D.A. Conner, D.J. Ladd, D. Kendall, J.E. Casanova, B. Corthesy, E.E. Max, M.R. Neutra, C.E. Seidman, and J.G. Seidman. 1995. Altered hepatic transport of immunoglobulin A in mice lacking the J chain. J. Exp. Med. 182:1905-1911.
31. Hendrickson, B., L. Rindisbacher, B. Corthesy, D. Kendall, D. Waltz, M. Neutra, and J. Seidman. 1996. Lack of association of secretory component with IgA in J chain-deficient mice. J. Immunol. 157:750-754.