Cholinergic and serotonergic alterations in the rat hippocampus following trimethyltin exposure and fetal neural transplantation

Neuroscience Letters

Volumn 259, Issue 3, 1999, Pages 173-176

  Roy, Adip ^a   Agrawal, A K ^a   Husain, R ^a   Dubey, M P ^b   Seth, P K ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Cholinergic; Raphe; Septal; Serotonergic; Transplantation; Trimethyltin

Indexed keywords

TRIMETHYLTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL TRANSPLANTATION; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DENERVATION; FEMALE; HIPPOCAMPUS; NERVE GRAFT; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM;

EID: 0033555625     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00825-8     Document Type: Article

References (20)

1. Agrawal A.K., Seth P.K., Squibb R.E., Tilson H.A., Uphouse L., Bondy S.C. Neurotransmitter receptors in brain regions of acrylamide treated rats I: Effect of single exposure to acrylamide. Pharmacol. Biochem. Behav. 14:1981;527-534.
2. Bjorklund A., Stenevi U. Reformation of the severed septohippocampal cholinergic pathway in the adult rat by transplanted septal neurons. Cell Tissue Res. 185:1977;289-302.
3. Cassel J.C., Neufang B., Kelche C., Jeltsch H., Will M.E., Hertting G., Jackish R. Effects of grafts containing cholinergic and/or serotonergic neurons on cholinergic, serotonergic and noradrenergic markers in the denervated rat hippocampus. Brain Res. 604:1993;53-63.
4. Dazuta A., Chazal G., Garcia S., Olerkevich S., Descarries L. Ultrastructural features of serotonin neurons grafted to adult rat hippocampus: an immunocytochemical analysis of their cell bodies and axon terminals. Neuroscience. 42:1991;793-811.
5. Earley B., Biegon A., Leonard B.E. Quantitative autoradiographic analysis of muscarinic receptors and quantitative histochemistry of acetylcholinesterase in the rat brain after trimethyltin intoxication. Neurochem. Int. 15:1989;475-483.
6. Earley B., Bruke M., Leonard B.E. Behavioural, biochemical and histopathological effects of trimethyltin (TMT) induced brain damage in rats. Neurochem. Int. 21:1992;351-366.
7. Ellman G.L., Lowetney D., Andres V. A rapid colorimetric assay for the determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:1961;88-95.
8. Isacson O., Deacon T. Neural transplantation studies reveal brain's capacity for continuous reconstruction. Trends Neurosci. 20:1997;477-482.
9. Kim C., Speisky M.B., Kharouba S.N. Rapid and selective method for measuring norepinephrine, dopamine, 5-hydroxytryptamine and their metabolites in the rat brain by high performance liquid chromatography. Differential effects of Probenecid, Haloperidol and Yohimbine on the concentration of biogenic amines and metabolites in various regions of rat brain. J. Chromatogr. 386:1987;25-35.
10. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement by Folin phenol reagent. J. Biol. Chem. 193:1951;165-175.
11. Lu S.Y., Norman A.B. Neurotransmitter receptors in fetal tissue transplants: expression and functional significance. J. Neural Transplant. Plast. 4:1993;215-226.
12. O'Connel A., Earley B., Leonard B.E. Changes in M1 and M2 muscarinic receptors following TMT intoxication. Neurochem. Int. 25:1994;243-252.
13. Pellegrino, L.J., Pellegrino, A.S. and Cushman, A.J., A Stereotaxic Atlas of the Rat Brain, Plenum Press, New York, 1979.
14. Perlow M.J., Freed W.J., Hoffer B.J., Seiger A., Olson L., Wyatt R.J. Brain graft reduce motor abnormalities produced by destruction of nigrostriatal dopaminergic system. Science. 204:1979;643-647.
15. Roy A., Agrawal A.K., Husain R., Seth P.K. Restoration of trimethyltin induced functional deficits by single and multiple transplantation. Restor. Neurol. Neurosci. 11:1997;195-201.
16. Scatchard G. The attraction of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51:1949;660-670.
17. Tarricone B.J., Simon J.R., Low W.C. Intrahippocampal transplants of septal cholinergic neurons: choline acetyltransferase activity, muscarinic receptor binding and spatial memory function. Brain Res. 622:1993;41-47.
18. Woodruff M.L., Baisden R.H. Exposure to trimethyltin significantly enhances acetylcholinesterase staining in the rat dentate gyrus. Neurotoxicol. Teratol. 12:1990;33-39.
19. Woodruff M.L., Baisden R.H., Whittington D.L., Shelton N.L., Wray S. Grafts containing fetal hippocampal tissue reduce activity and improve passive avoidance in hippocampectomized and trimethyltin exposed rats. Exp. Neurol. 102:1988;130-143.
20. Zhou F.C., Auerbach S.B., Azmitia E.C. Transplanted raphe and hippocampal fetal neurons do not displace afferent inputs to the dorsal hippocampus or serotonergic neurons in the median raphe nucleus of the rat. Brain Res. 50:1988;51-59.