Outer membrane vesicles from group B meningococci are strongly immunogenic when given intranasally to mice

Vaccine

Volumn 17, Issue 19, 1999, Pages 2336-2345

  Dalseg, Rolf ^a   Wedege, Elisabeth ^a   Holst, Johan ^a   Haugen, Inger Lise ^a   Høiby, E Arne ^a   Haneberg, Bjørn ^a,b  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

Antibodies; Memory; Mucosal immunization; Neisseria meningitidis

Indexed keywords

ADJUVANT; ANTIBODY; CHOLERA TOXIN; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; VACCINE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; IMMUNOLOGICAL MEMORY; INTRANASAL DRUG ADMINISTRATION; MEMBRANE VESICLE; MOUSE; MUCOSA; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; RECTAL DRUG ADMINISTRATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, BACTERIAL; BLOOD BACTERICIDAL ACTIVITY; CHOLERA TOXIN; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; IMMUNITY, MUCOSAL; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED BALB C; NEISSERIA MENINGITIDIS; POLYSACCHARIDES, BACTERIAL;

EID: 0033553668     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00046-8     Document Type: Article

References (48)

1. Peltola H. Meningococcal disease: still with us. Rev Infect Dis. 5:1983;71-91.
2. Schwartz B., Moore P.S., Broome C.V. Global epidemiology of meningococcal disease. Clin Microbiol Rev. 2:1989;S118-S124.
3. Kasper D.L., Winkelhake J.L., Brandt B.L., Artenstein M.S. Antigen specificity of bactericidal antibodies in antisera to Neisseria meningitidis. J Infect Dis. 127:1973;378-387.
4. Wyle F.A., Artenstein M.S., Brandt B.L., Tramont E.C., Kasper D.L., Altieri P.L., Berman S.L., Lowental J.P. Immunologic response of man to group B meningococcal polysaccharide vaccines. J Infect Dis. 126:1972;514-522.
5. Reingold A.L., Broome C.V., Hightower A.W., Ajello G.W., Bolan G.A., Adamsbaum C., Jones E.E., Phillips C., Tiendrebeogo H., Yada A. Age-specific differences in duration of clinical protection after vaccination with meningococcal polysaccharide A vaccine. Lancet. II:1985;114-118.
6. Bjune G., Høiby E.A., Grønnesby J.K., Arnesen O., Fredriksen J.H., Halstensen A., Holten E., Lindbak A.K., Nøkleby H., Rosenqvist E., Solberg L.K., Closs O., Eng J., Frøholm L.O., Lystad A., Bakketeig L.S., Hareide B. Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway. Lancet. 338:1991;1093-1096.
7. Sierra V.G., Campa H.C., Garcia L.I., Sotolongo F.P., Izquierdo L.P. Efficacy evaluation of the Cuban vaccine VA-MENGOC-BC against disease caused by serogroup B Neisseria meningitidis. Achtman M., Kohl P., Marchal C., et al. Neisseriae. 1990;129-134 Walter de Gruyter, Berlin.
8. Pan American Health Organization. Report of Pan American Health Organization Meeting 19-20 June, 1995, Washington, DC. Immunogenicity and reactogenicity of two outer membrane protein-based anti-meningococcal vaccines in Santiago, Chile.
9. Tsai C.M., Frasch C.E., Mocca L.F. Five structural classes of major outer membrane proteins in Neisseria meningitidis. J Bacteriol. 146:1981;69-78.
10. Olyhoek A.J.M., Sarkari J., Bopp M., Morelli G., Achtman M. Cloning and expression in Escherichia coli of opc, the gene for an unusual class 5 outer membrane protein from Neisseria meningitidis. Microb Pathog. 11:1991;249-257.
11. Rosenqvist E., Høiby E.A., Wedege E., Kusecek B., Achtman M. The 5C protein of Neisseria meningitidis is highly immunogenic in humans and induces bactericidal antibodies. J Infect Dis. 167:1993;1063-1065.
12. Rosenqvist E., Høiby E.A., Wedege E., Bryn K., Kolberg J., Klem A., Rønnild E., Bjune G., Nøkleby H. Human antibody responses to meningococcal outer membrane antigens after three doses of the Norwegian group B meningococcal vaccine. Infect Immun. 63:1995;4642-4652.
13. Virji M., Makepeace K., Ferguson D.J.P., Achtman M., Moxon E.R. Meningococcal Opa and Opc proteins: their role in colonization and invasion of human epithelial and endothelial cells. Mol Microbiol. 10:1993;499-510.
14. Rosenqvist E. Personal communication.
15. Rosenqvist E., Bjune G., Feiring B., Frøholm L.O., Høiby E.A., Moe B., Nøkleby H. Changes in carrier status of Neisseria meningitidis in teenagers during a group B outer membrane vaccination trial in Norway. Conde-Glez C.J., Morse S., Rice P., Sparling F., Calderón E. Pathobiology and immunobiology of Neisseriaceae. 1994;895-901 Instituto Nacional de Salud Publica.
16. Elson C.O., Ealding W. Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin. J Immun. 132:1984;2736-2741.
17. Lycke N., Holmgren J. Intestinal mucosal memory and presence of memory cells in lamina propria and Peyer's patches in mice 2 years after oral immunization with cholera toxin. Scand J Immun. 23:1986;611-616.
18. Lycke N., Holmgren J. Long-term cholera antitoxin memory in the gut can be triggered to antibody formation associated with protection within hours of an oral challenge immunization. Scand J Immun. 25:1987;407-412.
19. Clements L.D., Hartzog N.M., Lyon F.L. Adjuvant activity of Escherichia coli heat-labile enterotoxin and effect on the induction of oral tolerance in mice to unrelated protein antigens. Vaccine. 6:1988;269-277.
20. deHaan L., Holtrop M., Verweij W.R., Agsteribbe E., Wilschut J. Mucosal immunogenicity of the Escherichia coli heat-labile enterotoxin: role of the A subunit. Vaccine. 14:1996;260-266.
21. Oka T., Honda T., Morokuma K., Ginnaga A., Ohkuma K., Sakoh M. Enhancing effect of pertussis toxin B oligomer on the immunogenicity of influenza vaccine administered intranasally. Vaccine. 12:1994;1255-1258.
22. Zhou F., Kraehenbuhl J.-P., Neutra M.R. Mucosal IgA response to rectally administered antigen formulated in IgA-coated liposomes. Vaccine. 13:1995;637-644.
23. Vadolas J., Davies J.K., Wright P.J., Strugnell R.A. Intranasal immunization with liposomes induces strong mucosal immune responses in mice. Eur J Immunol. 25:1995;969-975.
24. Abraham E. Intranasal immunization with bacterial polysaccharide containing liposomes enhances antigen-specific pulmonary secretory antibody response. Vaccine. 10:1992;461-468.
25. de Haan A., Renegar K.B., Small P.A. Jr., Wilschut J. Induction of a secretory IgA response in the murine female urogenital tract by immunization of the lungs with liposome-supplemented viral subunit antigen. Vaccine. 13:1995;613-616.
26. Noll A., Autenrieth I.B. Immunity against Yersinia enterocolitica by vaccination with Yersinia HSP60 immunostimulating complexes or Yersinia HSP60 plus interleukin-12. Infect Immun. 64:1996;2955-2961.
27. Estrada A., Laarveld B., Li B., Redmond M.J. Induction of systemic and mucosal immune responses following immunization with somatostatin-avidin complexes incorporated into ISCOMS. Immunol Invest. 24:1995;819-828.
28. Morein B., Sundquist B., Höglund S., Dalsgaard K., Osterhaus A. Iscom, a novel structure for antigenic presentation of membrane proteins from enveloped viruses. Nature. 308:1984;457-460.
29. Hsu S.-C., Schadeck E.B., Delmas A., Shaw M., Steward M.W. Linkage of a fusion peptide to a CTL epitope from the nucleoprotein of measles virus enables incorporation into ISCOMs and induction of CTL responses following intranasal immunization. Vaccine. 14:1996;1159-1166.
30. Orr N., Robin G., Cohen D., Arnon R., Lowell G.H. Immunogenicity and efficacy of oral or intranasal Shigella flexneri 2a and Shigellla sonnei proteosome-lipopolysaccharide vaccines in animal models. Infect Immun. 61:1993;2390-2395.
31. Mallett C.P., Hale T.L., Kaminski R.W., Larsen T., Orr N., Cohen D., Lowell G.H. Intranasal or intragastric immunization with proteosome Shigella lipopolysaccharide vaccines protects against lethal pneumonia in a murine model of Shigella infection. Infect Immun. 63:1995;2382-2386.
32. Levi R., Aboud-Pirak E., Leclerc C., Lowell G.H., Arnon R. Intranasal immunization of mice against influenza with synthetic peptides anchored to proteosomes. Vaccine. 13:1995;1353-1359.
33. Dalseg R., Holst J., Tangen T., Stabbetorp G., Simonsen P., Jantzen E., Haneberg B., Namork E., Haaheim L.R. Outer membrane vesicles from group-B meningococci can act as mucosal adjuvant for influenza virus antigens. Brown F., Norrby E., Burton D., Mekalanos J. Vaccines 96: Molecular approaches to the control of infectious diseases. 1996;177-182 Cold Spring Harbor Laboratory Press, New York.
34. Fredriksen J.H., Rosenqvist E., Wedege E., Bryn K., Bjune G., Frøholm L.O., Lindbak A.-K., Møgster B., Namork E., Rye U., Stabbetorp G., Winsnes R., Aase B., Closs O. Production, characterization and control of MenB-Vaccine 'FOLKEHELSA': An outer membrane vesicle vaccine against group B meningococcal disease. NIPH Ann. 14:1991;67-80.
35. Haneberg B., Kendall D., Amerongen H.M., Apter F.M., Kraehenbuhl J.-P., Neutra M.R. Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for collection of secretions from local mucosal surfaces. Infect Immun. 62:1994;15-23.
36. Wedege E., Høiby E.A., Rosenqvist E., Frøholm L.O. Serotyping and subtyping of Neisseria meningitidis isolates by co-agglutination, dot-blotting and ELISA. J Med Microbiol. 31:1990;195-201.
37. Wedege E., Bryn K., Frøholm L.O. Restoration of antibody binding to blotted meningococcal outer membrane proteins using various detergents. J Immunol Methods. 113:1988;51-59.
38. Høiby E.A., Rosenqvist E., Frøholm L.O., Bjune G., Feiring B., Nøkleby H., Rønhild E. Bactericidal antibodies after vaccination with the Norwegian meningococcal serogroup B outer membrane vesicle vaccine: A brief survey. NIPH Annals. 14:1991;147-156.
39. Perkins B.A., Jonsdottir K., Briem H., Griffiths E., Plikaytis B.D., Høiby E.A., Rosenqvist E., Holst J., Nøkleby H., Sotolongo F., Sierra G., Campa H.C., Carlone G.M., Williams D., Dykes J., Kapczynski D., Tikhomirov E., Wenger J.D., Broome C.V. Immunogenicity of two efficacious outer membrane protein-based serogroup B meningococcal vaccines among young adults in Iceland. J Infect Dis. 177:1998;683-691.
40. Berstad A.K.H., Holst J., Møgster B., Haugen I.L., Haneberg B. A nasal whole-cell pertussis vaccine can induce strong systemic and mucosal antibody responses which are not enhanced by cholera toxin. Vaccine. 15:1997;1473-1478.
41. Salit I.E., Tomalty L. Experimental meningococcal infection in mice: A model for mucosal invation. Infect Immun. 51:1986;648-652.
42. Mackinnon F.G., Gorringe A.R., Funnell S.G.P., Robinson A. Intranasal infection of infant mice with Neisseria meningitidis. Microb Pathog. 12:1992;415-420.
43. Apicella M.A. Neisseria meningitidis. Mandell G., Bennett J.E., Dolin R. Principles and practice of infectious diseases. 1995;1896-1909 Churchill Livingstone, New York.
44. Haneberg B., Dalseg R., Wedege E., Høiby E.A., Haugen I.L., Oftung F., Andersen S.R., Næss L.M., Aase A., Michaelsen T.E., Holst J. Intranasal administration of a meningococcal outer membrane vesicle vaccine induces persistent local mucosal antibodies and serum antibodies with strong bactericidal activity in humans. Infect Immun. 66:1998;1334-1341.
45. Rosenqvist E., Høiby E.A. Relative bactericidal activity of IgG antibodies against outer membrane complexes from meningococci, as a function of vaccine type, dose and time after vaccination. Achtman M., Kohl P., Marchal C., Morelli G., Seiler A., Thiesen B. Neisseriae 1990. Proceedings of the seventh international pathogenic neisseria conference. 1991;265-269 Walter de Gruyter, Berlin, New York.
46. Jarvis G.A., Griffiss J.M. Human IgA blockade of IgG-initiated lysis of Neisseria meningitidis is a function of antigen-binding fragment binding to the polysaccharide capsule. J Immunol. 147:1991;1962-1967.
47. Wetzler L.W., Ho Y., Reiser H. Neisserial porins induce B lymphocytes to express costimulatory B7-2 molecules and to proliferate. J Exp Med. 183:1996;1151-1159.
48. Liu Y.-J., Barthélémy C., de Boutellier O., Arpin C., Durand I., Banchereau J. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity. 2:1995;239-248.