Synthesis of ascomycin and FK 506 derivatives with modified effector domain

Tetrahedron Letters

Volumn 40, Issue 20, 1999, Pages 3869-3872

  Nussbaumer, Peter ^a   Grassberger, Maximilian A ^a   Schulz, Gerhard ^a  

^a NOVARTIS Forschungsinstitut Wien   (Austria)

Author keywords

Carbenes and carbenoids; Diazo compounds; Hydrazones; Macrolides

Indexed keywords

ASCOMYCIN; CYCLOPROPANE DERIVATIVE; DICHLOROMETHANE; HYDRAZONE DERIVATIVE; MANGANESE DIOXIDE; METHANOL; TACROLIMUS;

ARTICLE; CHEMICAL REACTION; DERIVATIZATION; DRUG ACTIVITY; DRUG BINDING SITE; DRUG MIXTURE; DRUG PURIFICATION; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

EID: 0033553446     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00629-2     Document Type: Article

References (9)

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3. [3] Bierer BE, Somers PK, Wandless TJ, Burakoff SJ, Schreiber SL. Science 1990; 250: 556-559.
4. [4] Stütz A, Grassberger MA, Baumann K, Edmunds AJF, Hiestand P, Meingassner JG, Nussbaumer P, Schuler W, Zenke G. In: Testa B, Kyburz E, Fuhrer W, Giger R, editors. Perspectives in Medicinal Chemistry. Basle: Verlag Helv. Chim. Acta and Weinheim: VCH, 1993: 427-443.
5. [5] Böhshar M, Fink J, Heydt H, Wagner O, Regitz M. In: Klamann D, Hagemann H, editors. Methods of Organic Chemistry. Stuttgart, New York: Georg Thieme Verlag, 1990; E14b: 996-1010.
6. [6] Eistert B, Regitz M, Heck G, Schwall H. In: Müller E, editor. Methods of Organic Chemistry. Stuttgart, New York: Georg Thieme Verlag, 1968; 10/4: 620-629.
7. [7] Nussbaumer P, Grassberger M, Schulz G. Tetrahedron Lett. 1992; 33: 3845-3846.
8. [8] The 24,33-bisOTBDMS derivative of 6b has been already described: Zimmer R, Grassberger MA, Baumann K, Schulz G, Haidl E. Tetrahedron 1994; 50: 13655-13670.
9. [9] Schulz G. Unpublished results.