Carboxy-substituted cinnamides: A novel series of potent, orally active LTB4 receptor antagonists

Journal of Medicinal Chemistry

Volumn 42, Issue 1, 1999, Pages 164-172

  Greenspan, Paul D ^a   Fujimoto, Roger A ^a   Marshall, Paul J ^a   Raychaudhuri, Anil ^a   Lipson, Kenneth E ^a   Zhou, Huanghai ^a   Doti, Robert A ^a   Coppa, David E ^a   Zhu, Lijuan ^a   Pelletier, Roberta ^a   Uziel Fusi, Susan ^a   Jackson, Robert H ^a   Chin, Michael H ^a   Kotyuk, Bernard L ^a   Fitt, John J ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CINNAMAMIDE DERIVATIVE; CINNAMIC ACID DERIVATIVE; LEUKOTRIENE B4; LEUKOTRIENE B4 RECEPTOR ANTAGONIST; MOXILUBANT MALEATE; MYELOPEROXIDASE; PHENYLCINNAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EDEMA; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; NEUTROPHIL; NONHUMAN; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; AMIDES; ANIMALS; CALCIUM; CINNAMATES; DRUG EVALUATION, PRECLINICAL; EAR; EDEMA; FEMALE; HUMANS; MICE; NEUTROPHILS; RECEPTORS, LEUKOTRIENE B4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033552867     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980540v     Document Type: Article

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