Effect of nitric-oxide-generating system on microcirculatory blood flow in skin of patients with severe Raynaud's syndrome: A randomised trial

Lancet

Volumn 354, Issue 9191, 1999, Pages 1670-1675

  Tucker, A T ^a   Pearson, R M ^a   Cooke, E D ^a   Benjamin, N ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; GLYCERYL TRINITRATE; NITRIC OXIDE; SODIUM NITRITE;

ADULT; ADVERSE DRUG REACTION; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FINGER BLOOD FLOW; FOREARM BLOOD FLOW; GEL; HUMAN; LASER DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; PHOTOELECTRIC PLETHYSMOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAYNAUD PHENOMENON; SINGLE BLIND PROCEDURE; SKIN BLOOD FLOW; SOLUTION AND SOLUBILITY; STATISTICAL ANALYSIS; TOPICAL DRUG ADMINISTRATION;

EID: 0033552396     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(99)04095-7     Document Type: Article

References (36)

1. Silman A., Holligan S., Brennan P., Maddison P. Prevalence of symptoms of Raynaud's phenomenon in general practice. BMJ. 301:1990;590-592.
2. Wigley F.M., Flavahan N.A. Raynaud's phenomenon. Rheum Dis Clin North Am. 22:1996;765-781.
3. Cooke E.D. Natural history and present day management of Raynaud's syndrome. Cooke E.D., Nicolaides A.N., Porter J.M. Raynaud's syndrome. 1995;149-158 Med-Orion, London.
4. Lewis T. Experiments relating to the peripheral mechanism involved in spasmodic arrest of the circulation of the fingers, a variety of Raynaud's syndrome. Heart. 15:1929;7-101.
5. Vanhoutte P.M., Cooke J.P., Linbald L.E., Shepherd T., Flavahan N.A. Modulation of post junctional alpha-adrenergic responsiveness by local changes in temperature. Clin Sic. 68:1985;121-123.
6. Belch J.J., Ho M. Pharmacotherapy of Raynaud's phenomenon. Drugs. 52:1996;682-695.
7. Bedarida G., Kim D., Blaschke T.F., Hoffman B.B. Venodilation in Raynaud's syndrome. Lancet. 342:1993;1451-1454.
8. Schiffrin E.L. The endothelium and control of blood vessel function in health and disease. Clin Invest Med. 17:1994;602-620.
9. Lüscher T.F., Vanhoutte P.M. The endothelium: modulator of cardiovascular function. 1988;CRP Press, Boston.
10. Palmer R.M., Ferrige A.G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 327:1987;524-526.
11. Benjamin N., O'Driscoll F., Dougall H.et al. Stomach NO synthesis. Nature. 368:1994;502.
12. Khan F, Benjamin N, Littleford RC, et al. Effects of a topical nitric oxide generating system on forearm skin blood flow. Presented at Cambridge Meeting on resistance vessel function, September 1996.
13. Weller R., Patullo S., Smith T., Golden M., Omerod A., Benjamin N. Nitric oxide is generated on the skin surface by reduction of sweat nitrate. J Invest Dermatol. 107:1996;327-331.
14. Millar T.M., Stevens C.R., Benjamin N., Eisenthal R., Harrison R., Blake D.R. Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions. FEBS Lett. 427:1998;225-228.
15. Cooke E.D., Steinberg M.D., Pearson R.M., Fleming C.E., Toms S.I., Elusade J.A. Reflex sympathetic dystrophy and repetitive strain injury: temperature and microcirculatory changes following mild cold stress. J R Soc Med. 86:1993;690-693.
16. Allen E.V., Brown G.E. Raynaud's disease: a clinical review of minimal requisites for diagnosis. Am J Med Sci. 183:1932;187-200.
17. Cooke E.D., Bowcock S.A., Smith A.T.A. mathematical model for the vascular behaviour of the hands in response to cold stress. Vasc Med. 3:1985;98-104.
18. Toms S., Cooke E.D.A. comparison of the functioning of arteriovenous anastomosis in secondary Raynaud's phenomenon and control subjects in response to local hand warming. Int Angiol. 1:1995;74-79.
19. Cooke E.D., Bowcock S.A., Smith A.T. Photoplethysmography of the distal pulp in the assessment of the vasospastic hand. Angiology. 36:1985;33-40.
20. Almond N.E. Laser Doppler flowmeter system and its application to the studies of the skin microcirculation in humans [PhD thesis]. 1987;University of London, London.
21. Belch J.J., Capell H.A., Cooke E.D.et al. Oral Iloprost as a treatment for Raynaud's syndrome: a double blind multicentre placebo controlled study. Ann Rheum Dis. 54:1995;197-200.
22. Challoner A.V.J. Photoelectric plethysmography for estimating cutaneous blood flow. Rolfe P. Non-invasive physiological measurements. 1979;125-151 Academic Press, New York.
23. Nilsson G.E., Tenlan T., Akeoberg P. Evaluation of a laser Doppler flowmeter for measurement of tissue blood flow. IEEE Trans Biomed Eng. 27:1980;597-604.
24. Conrad M.C. The circulation to the skin. Functional anatomy of the lower extremites. 1971;64-65 Year Book Medical Publishers, Chicago.
25. Nilsen K.H. Effects of naftidrofuryl on microcirculatory cold sensitivity in Raynaud's phenomenon. BMJ. 1:1979;20-21.
26. Sunderland G.T., Belch J.J., Sturrock R.D., Forbes C.D., McKay A.J.A. double blind randomised placebo controlled trial of Hexopal in primary Raynaud's disease. Clin Rheumatol. 7:1988;46-49.
27. Stellin G.P., Waxman K. Current and potential therapeutic effects of pentoxifylline. Compr Ther. 15:1989;11-13.
28. Cooke E.D., Nicholaides A.N. Raynaud's syndrome. BMJ. 300:1990;55355.
29. Fisher M., Grotta J. New uses for calcium channel blockers: therapeutic implications. Drugs. 46:1993;961-975.
30. Rademaker M., Cooke E.D., Almond N.E.et al. Comparison of intravenous infusions of Iloprost and oral nifedipine in treatment of Raynaud's phenomenon in patients with systemic sclerosis: a double blind randomised study. BMJ. 298:1989;561-564.
31. Dowd P.M., Martin M.F., Cooke E.D.et al. Treatment of Raynaud's phenomenon by intravenous infusion of prostacyclin (PGI). Br J Dermatol 1982. 106:2;81-89.
32. Brain S.D., Petty R.G., Lewis J.D., Williams T.J. Cutaneous blood flow responses in the forearms of Raynaud's patients induced by local cooling and intradermal injections of CGRP and histamine. Br J Clin Pharmacol. 30:1990;853-859.
33. Kahaleh M.B. Raynaud's phenomenon and vascular disease in scleroderma. Curr Opin Rheumatol. 6:1994;621-627.
34. Bunker C.B., Goldsmith P.C., Leslie T.A., Hayes N., Foreman J.C., Dowd P.M. Calcitonin gene-related peptide, endothelin-1, the cutaneous microvasculature and Raynaud's phenomenon. Br J Dermat. 134:1996;399-406.
35. Cooke J.P., Creager S.J., Scales K.M.et al. Role of digital artery adrenoceptors in Raynaud's disease. Vasc Med. 2:1997;1-7.
36. Weller R., Ormerod A.D., Hobson R.P., Benjamin N.J.A. randomised trial of acidified nitrite cream in the treatment of tinea pedis. J Am Acad Dermatol. 38:1998;559-563.