Bilosespens A and B: Two novel cytotoxic sesterpenes from the marine sponge Dysidea cinerea

Organic Letters

Volumn 1, Issue 3, 1999, Pages 471-472

  Rudi, Amira ^a   Yosief, Tesfamariam ^a   Schleyer, Michael ^b   Kashman, Yoel ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b OCEANOGRAPHIC RESEARCH INSTITUTE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BILOSESPEN A; BILOSESPEN B; TERPENE;

ANIMAL; ARTICLE; CELL CULTURE; CHEMISTRY; ERITREA; HUMAN; ISOLATION AND PURIFICATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SPONGE (PORIFERA);

ANIMALS; ERITREA; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PORIFERA; TERPENES; TUMOR CELLS, CULTURED;

EID: 0033549667     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol990058m     Document Type: Article

References (9)

1. Kashman, Y.; Koren-Goldshlager, G.; Garcia Gravalos, M. D.; Schleyer, M. Tetrahedron 1999, 40, 997.
2. Koren-Goldshlager, G.; Aknin, M.; Gaydou, E. M.; Kashman, Y. J. Org. Chem. 1998, 63, 4601.
3. Kelman, D.; Kushmaro, A.; Loya, Y.; Kashman, Y.; Benayahu, Y. Mar. Ecol. Prag. Ser. 1998, 169, 87.
4. Earlier investigation of this sponge collected in the northern part of the Red Sea yielded only avarol derivatives: Hirsh, S.; Rudi, A.; Loya, Y.; Kashman, Y. J. Nat. Prod. 1991, 54, 92.
5. The decomposition seems to be autocatalyzed by the carboxylic group.
6. +, respectively, of the Decalin portion.
7. (a) Bax, A. J. Magn. Reson. 1984, 57, 314.
8. (b) Bax, A.; Ferrett, J. A.; Nashed, N.; Jerina, D. M. J. Org. Chem. 1985, 50, 3029. The selective-SPT experiment gives a better resolution than the HMBC one.
9. Faulkner, D. J. Nat. Prod. Rep. 1997, 14, 259, and earlier reports in this series.