GABA may function tonically via GABA(A) receptors to inhibit hypotension and bradycardia by L-DOPA microinjected into depressor sites of the nucleus tractus solitarii in anesthetized rats

Neuroscience Letters

Volumn 261, Issue 1-2, 1999, Pages 93-96

  Honjo, Kaneyoshi ^a   Goshima, Yoshio ^a   Miyamae, Takeaki ^a   Misu, Yoshimi ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Competitive DOPA antagonist; Depressor responses to DOPA; GABA(A) receptors; Microinjection; Nucleus tractus solitarii; Pressor responses to GABA

Indexed keywords

LEVODOPA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL REACTIVITY; BRADYCARDIA; BRAIN MEMBRANE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DENERVATION; DEPRESSOR RESPONSE; DRUG RECEPTOR BINDING; GABAERGIC TRANSMISSION; HYPOTENSION; NERVE STIMULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SOLITARY TRACT NUCLEUS;

ANESTHESIA; ANIMALS; BICUCULLINE; BINDING, COMPETITIVE; BRADYCARDIA; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HYPOTENSION; LEVODOPA; MALE; MICROINJECTIONS; NIPECOTIC ACIDS; PRESSORECEPTORS; PROLINE; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SOLITARY NUCLEUS; TRITIUM;

EID: 0033548023     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00010-5     Document Type: Article

References (17)

1. Bowery N.G., Hudson A.L., Price G.W. GABA-A and GABA-B receptor binding site distribution in the rat central nervous system. Neuroscience. 20:1987;365-385.
2. Catelli J.M., Giakas W.J., Sved A.F. GABAergic mechanisms in nucleus tractus solitarius alter blood pressure and vasopressin release. Brain Res. 403:1987;279-289.
3. Goshima Y., Kubo T., Misu Y. Biphasic actions of L-DOPA on the release of endogenous noradrenaline and dopamine from rat hypothalamic slices. Br. J. Pharmacol. 89:1986;229-234.
4. Goshima Y., Nakamura S., Misu Y. L-Dihydroxyphenylalanine methyl ester is a potent competitive antagonist of the L-dihydroxyphenylalanine-induced facilitation of the evoked release of endogenous norepinephrine from rat hypothalamic slices. J. Pharmacol. Exp. Ther. 258:1991;466-471.
5. Hwang B.H., Wu J.Y. Ultrastructural studies on catecholaminergic terminals and GABAergic neurons in nucleus tractus solitarius of the rat medulla oblongata. Brain Res. 302:1984;57-67.
6. Kubo T., Kihara M. Evidence for the presence of GABAergic and glycine-like systems responsible for cardiovascular control in the nucleus tractus solitarii of the rat. Neurosci. Lett. 74:1987;331-336.
7. Kubo T., Kihara M. Evidence for γ-aminobutyric acid receptor-mediated modulation of the aortic baroreceptor reflex in the nucleus tractus solitarii of the rat. Neurosci. Lett. 89:1988;156-160.
8. Kubo T., Yue J.-L., Goshima Y., Nakamura S., Misu Y. Evidence for L-DOPA systems responsible for cardiovascular control in the nucleus tractus solitarii of the rat. Neurosci. Lett. 140:1992;153-156.
9. Misu Y., Goshima Y. Is L-dopa an endogenous neurotransmitter? Trends Pharmacol. Sci. 14:1993;119-123.
10. Misu Y., Goshima Y., Ueda H., Okamura H. Neurobiology of L-DOPAergic systems. Prog. Neurobiol. 49:1996;415-454.
11. Miyamae, T., Goshima, Y., Shimizu, M., Shibata, T., Kawashima, K., Ohshima, E., Suzuki, F. and Misu, Y., Some interactions of L-DOPA and its related compounds with glutamate receptors, Life Sci., 64 (1999) in press.
12. Reis D.J., Granata A.R., Perrone M.H., Talman W.T. Evidence that glutamic acid is the neurotransmitter of baroreceptor afferents terminating in the nucleus tractus solitarius (NTS). J. Auton. Nerv. Syst. 3:1981;321-334.
13. Talman W.T., Perrone M.H., Reis D.J. Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers. Science. 209:1980;813-815.
14. Tison F., Mons N., Rouet-Kamara S., Geffard M., Henry P. Endogenous L-DOPA in the rat dorsal vagal complex: an immunocytochemical study by light and electron microscopy. Brain Res. 497:1989;260-270.
15. Yue J.-L., Okamura H., Goshima Y., Nakamura S., Geffard M., Misu Y. Baroreceptor-aortic nerve-mediated release of endogenous L-3,4-dihydroxyphenylalanine and its tonic depressor function in the nucleus tractus solitarii of rats. Neuroscience. 62:1994;145-161.
16. Yue J.-L., Okumura Y., Miyamae T., Ueda H., Misu Y. Altered tonic L-3,4-dihydroxyphenylalanine systems in the nucleus tractus solitarii and the rostral ventrolateral medulla of spontaneously hypertensive rats. Neuroscience. 67:1995;95-106.
17. Zukin S.R., Young A.B., Snyder S.H. Gamma-aminobutyric acid binding to receptor sites in the rat central nervous system. Proc. Natl. Acad. Sci. USA. 71:1974;4802-4807.