Dysregulation of the hypothalamopituitary-adrenal axis is related to the clinical course of MS

Neurology

Volumn 53, Issue 4, 1999, Pages 772-777

  Bergh, Florian Then ^a,b   Kumpfel T ^a   Trenkwalder, C ^a   Rupprecht, R ^a   Holsboer, F ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Dexamethasone CRH test; Hypothalamo pituitary adrenal axis; MS

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; CORTICOTROPIN; DIAGNOSTIC AGENT; HYDROCORTISONE;

ADULT; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS FUNCTION DISORDER; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; BLOOD; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; PATHOPHYSIOLOGY;

ADRENOCORTICOTROPIC HORMONE; ADULT; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MULTIPLE SCLEROSIS; PITUITARY-ADRENAL SYSTEM;

EID: 0033546799     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/wnl.53.4.772     Document Type: Article

References (23)

1. Besedovsky HO, del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr Rev 1996;17:64-102.
2. Reder AT, Lowy MT, Meltzer HY, Antel JP. Dexamethasone suppression test abnormalities in multiple sclerosis: relation to ACTH therapy. Neurology 1987;37:849-853.
3. Reder AT, Makowiec RL, Lowy MT. Adrenal size is increased in multiple sclerosis. Arch Neurol 1994;51:151-154.
4. Michelson D, Stone L, Galliven E, et al. Multiple sclerosis is associated with alterations in hypothalamic-pituitary-adrenal axis function. J Clin Endocrinol Metab 1994;79: 848-853.
5. Purba JS, Raadsheer FC, Hofman MA, et al. Increased number of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of patients with multiple sclerosis. Neuroendocrinology 1995;62:62-70.
6. Erkut ZA, Hofman MA, Ravid R, Swaab DF. Increased activity of hypothalamic corticotropin-releasing hormone neurons in multiple sclerosis. J Neuroimmunol 1995;62:27-33.
7. Grasser A, Möller A, Backmund H, Yassouridis A, Holsboer F. Heterogeneity of hypothalamic-pituitary-adrenal system response to a combined dexamethasone-CRH test in multiple sclerosis. Exp Clin Endocrinol Diab 1996;104:31-37.
8. Wei T, Lightman SL. The neuroendocrine axis in patients with multiple sclerosis. Brain 1997;120:1067-1076.
9. Fassbender K, Schmidt R, Mossner R, et al. Mood disorders and dysfunction of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: association with cerebral inflammation. Arch Neurol 1998;55:66-72.
10. Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983;13:227-231.
11. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983;33:1444-1452.
12. Hamilton M. Development of a rating scale for primary depressive illness. Br J Consult Clin Psychol 1967;6:278-296.
13. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 1996;46:907-911.
14. Matthews WB, ed. McAlpine's multiple sclerosis. 2nd ed. Edinburgh: Churchill Livingstone, 1991.
15. Thompson AJ, Polman CH, Miller DH, et al. Primary progressive multiple sclerosis. Brain 1997;120:1085-1096.
16. von Bardeleben U, Holsboer F. Cortisol response to a combined dexamethasone-human corticotropin-releasing hormone challenge in patients with depression. J Neuroendocrinol 1989;1:485-488.
17. Heuser I, Yassouridis A, Holsboer F. The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J Psychiatr Res 1994;28:341-356.
18. Barden N Reul JMHM, Holsboer F. Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? Trends Neurosci 1995;18:6-11.
19. Sullivan F, Hutchinson M, Bahandeka S, Moore RE. Chronic hypothermia in multiple sclerosis. J Neurol Neurosurg Psychiatry 1987;50:813-815.
20. Redei E, Rittenhouse PA, Revskoy S, McGivern RF, Aird F. A novel endogenous corticotropin release inhibiting factor. Ann NY Acad Sci 1998;840:456-469.
21. Antoni FA. Vasopressinergic control of pituitary adrenocortin secretion comes of age. Front Neuroendocrinol 1993;14:76-122.
22. Harbuz MS, Rees RG, Eckland D, Jessop DS, Brewerton D, Lightman SL. Paradoxical response of hypothalamic corticotrophin-releasing factor (CRF) messenger ribonucleic acid (mRNA) and CRH-41 peptide and adenohypophyseal proopiomelanocortin mRNA during chronic inflammatory stress. Endocrinology 1992;130:1394-1400.
23. Aguilera G. Regulation of pituitary ACTH secretion during chronic stress. Front Neuroendocrinol 1994;15:321-350.