Agrochelin, a new cytotoxic alkaloid from the marine bacteria Agrobacterium sp.

Tetrahedron Letters

Volumn 40, Issue 37, 1999, Pages 6841-6844

  Cañedo, Librada M ^a   De la Fuente, Jesús A ^a   Gesto, Cristina ^a   Ferreiro, María J ^b   Jiménez, Carlos ^c   Riguera, Ricardo ^b  

^a Instituto Biomar SA   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^c UNIVERSITY OF A CORUÑA   (Spain)

Author keywords

Antitumour; Marine alkaloids; Thiazolines; Zn2+ chelation

Indexed keywords

MARINE TOXIN; ZINC ION;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHELATION; CHEMICAL MODIFICATION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE AEROBIC RODS AND COCCI; NONHUMAN; RHIZOBIUM; STRUCTURE ANALYSIS;

AGROBACTERIUM; AGROBACTERIUM SP.; BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 0033543622     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)01377-5     Document Type: Article

References (9)

1. (a) Fenical, W. Chem. Rev. 1993, 93, 1673-1683.
2. (b) Pietra, F. Nat. Prod. Reports 1997, 14, 453-464.
3. (c) Faulkner, D. Nat. Prod. Reports 1998, 15, 113-158, and references cited therein.
4. 1H NMR data: see Table 1.
5. Kobayashi, S.; Nakai, H.; Ikenishi, Y.; Sun, W. Y.; Ozaki, M.; Hayase, Y.; Takeda, R. J. Antibiotics 1998, 51, 328-332.
6. Drechsel, H.; Stephan, H.; Lotz, R.; Haag, H.; Zähner, H.; Hantke, K.; Jung, G. Liebigs Ann. 1995, 1727-1733.
7. Chambers, C. E.; McIntyre, D. D.; Mouck, M.; Sokol, P. A. Biometals 1996, 9, 157-167.
8. Jalal, M. A. F.; Hossain, M. B.; Van der Helm, D.; Sanders-Loehr, J.; Actis, L. A.; Crosa, J. H. J. Am. Chem. Soc. 1989, 111, 292-296.
9. -1): 222 (7.78), 257 (-9.80), 276 (1.49), 294 (-2.63), 355 (3.59).