Describing shape dynamics in transformed cells through latent factors

Experimental Cell Research

Volumn 246, Issue 1, 1999, Pages 69-82

  Heckman, C A ^a   Jamasbi, R J ^a  

^a BOWLING GREEN STATE UNIVERSITY   (United States)

Author keywords

Computer assisted microscopy; Image analysis; Protein kinase C; Ras oncogene; Tumor promotion

Indexed keywords

ANIMAL CELL; ARTICLE; CELL SHAPE; CELL TRANSFORMATION; HYPOTHESIS; IMAGE ANALYSIS; MATHEMATICAL ANALYSIS; MOLECULAR DYNAMICS; NONHUMAN; PATTERN RECOGNITION; PHENOTYPE; PRIORITY JOURNAL; RAT; STRUCTURE ANALYSIS;

ANIMALIA;

EID: 0033540278     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.4242     Document Type: Article

References (24)

1. Heckman C. A. Cell shape and growth control. Advances in Cell Culture. 1985;Academic Press, New York. p. 85-156.
2. Heckman C. A., Campbell A. E., Wetzel B. Characteristic shape and surface changes in epithelial transformation. Exp. Cell Res. 169:1987;127-148.
3. Heckman C. A., Plummer H. K. III, Runyeon C. S. Persistent effects of phorbol 12-myristate 13-acetate: Possible implication of vesicle traffic. J. Cell. Physiol. 166:1996;217-230.
4. Spearman C. General intelligence, objectively determined and measured. Am. J. Psychol. 15:1904;201-293.
5. Heckman C. A., Hansen T. Factor analysis as a means of assessing subcellular mass distribution. Mol. Biol. Cell. 5:1994;171a.
6. Heckman C. A. Geometrical constraints on the shape of culture cells. Cytometry. 11:1990;771-783.
7. Qiu R.-G., Abo A., McCormick F., Symons M. Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation. Mol. Cell. Biol. 17:1997;3449-3458.
8. SAS/STAT User's Guide. 1989;SAS Institute, Cary.
9. Plummer H. K. III, Heckman C. A. Transient expression of the transformed phenotype stimulated by 12-O-tetradecanoyl phorbol-13-acetate. Exp. Cell Res. 188:1990;66-74.
10. Marchok A. C., Rhoton J. C., Nettesheim P. In vitroin vivo. Cancer Res. 38:1978;2030-2037.
11. Kuroki T., Drevon C., Saint Vincent L., Tomatis L., Montesano R. Studies on the use of liver parenchymal cells inin vitro. Mecanisms d'Altération et de Réparation du DNA: Relations avec la Mutagenèse et la Cancérogénèse Chimique. 1977;Centre National de Recherche Scientifique, Paris. p. 307-314.
12. Manger R. L., Heckman C. A. Structural anomalies of highly malignant respiratory tract epithelial cells. Cancer Res. 42:1982;4591-4599.
13. Steele V. E., Marchok A. C., Nettesheim P. Establishment of epithelial cell lines following exposure of cultured tracheal epithelium to 12-O-tetradecanoyl-phorbol-13-acetate. Cancer Res. 38:1978;3563-3565.
14. Olson A. C., Larson N. M., Heckman C. A. Classification of cultured mammalian cells by shape analysis and pattern recognition. Proc. Natl. Acad. Sci. USA. 77:1980;1516-1520.
15. Dixon W. J. BMDP Statistical Software Manual. 1992;Univ. of California Press, Berkeley.
16. Heckman C. A. Agents affecting microtubules stimulate the expression of the transformed shape phenotype. J. Cell Biol. 111:1990;52a.
17. Bannikov G. A., Guelstein V. I., Montesano R., Tint I. S., Tomatis L., Troyanovsky S. M., Vasiliev J. M. Cell shape and organization of cytoskeleton and surface fibronectin in non-tumorigenic and tumorigenic rat liver cultures. J. Cell Sci. 54:1982;47-67.
18. Heckman, C. A. Plummer, H. K. III, Mukherjee, R. 1998, Enhancement of the transformed shape phenotype by microtubule (MT) inhibitors and reversal by a MT inhibitor combination (IC).
19. Kozma R., Ahmed S., Best A., Lim L. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol. 15:1995;1942-1952.
20. 1, Science, 269, 1270, 1273, 1995.
21. Ridley A. J., Paterson H. F., Johnston C. L., Diekmann D., Hall A. The small GTP-binding protein rac regulates growth-factor-induced membrane ruffling. Cell. 70:1992;401-410.
22. Manser E., Huang H.-Y., Loo T.-H., Chen X.-Q., Dong J.-M., Leung T., Lim L. Expression of constitutively active α-PAK reveals effects of the kinase on actin and focal complexes. Mol. Cell. Biol. 17:1997;1129-1143.
23. Heckman C. A., Oravecz K. I., Schwab D., Pontén J. Ruffling and locomotion: role in cell resistance to growth factor-induced proliferation. J. Cell. Physiol. 154:1993;544-565.
24. Bar-Sagi D., Feramisco J. R. Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts byras. Science. 233:1986;1061-1068.