A facile synthesis of 3-aryl-substituted-benzothiophenes via a Lewis acid mediated cyclization of 2-arylthio-acetophenones

Tetrahedron Letters

Volumn 40, Issue 15, 1999, Pages 2909-2912

  Kim, Seongkon ^a   Yang, Jane ^a   DiNinno, Frank ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOTHIOPHENE;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; HYPOTENSION; OSTEOPOROSIS; POSTMENOPAUSE; REACTION ANALYSIS; THIN LAYER CHROMATOGRAPHY;

EID: 0033538007     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00392-5     Document Type: Article

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20. +).
21. Although the desired product 2a-h was contaminated by ca. 10% of 13a-h, no serious attempt was made to effect separation. Instead, it was found that the mixture could be used in a synthetic sequence which provided more readily purified materials.