A dominant-negative pleiotrophin mutant introduced by homologous recombination leads to germ-cell apoptosis in male mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 12, 1999, Pages 6734-6738

  Zhang, Nan ^a   Yeh, Hsiu Jeng ^a   Zhong, Rong ^a   Li, Yue Sheng ^a,b   Deuel, Thomas F ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PLEIOTROPHIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CENTRAL NERVOUS SYSTEM; CHIMERA; CONTROLLED STUDY; GENE EXPRESSION; GERM CELL; GERM LAYER; MALE; MESENCHYME; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPERMATOGENESIS; TESTIS;

ALLELES; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL DIFFERENTIATION; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, DOMINANT; GROWTH SUBSTANCES; HUMANS; MALE; MICE; MUTATION; NERVE TISSUE PROTEINS; RECOMBINATION, GENETIC; TESTIS;

ANIMALIA;

EID: 0033535988     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.12.6734     Document Type: Article

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