Aging and corticosterone injections affect spatial learning in Fischer- 344 x Brown Norway rats

Brain Research

Volumn 827, Issue 1-2, 1999, Pages 93-103

  Hebda Bauer, Elaine K ^a,b   Morano, Maria Ines ^b   Therrien, Barbara ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Aging; Corticosterone; Fischer 344 x Brown Norway rat; Hippocampus; Memory; Spatial learning

Indexed keywords

CORTICOSTERONE;

AGED; AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; LEARNING DISORDER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL DISCRIMINATION; SWIMMING; TASK PERFORMANCE;

AGE FACTORS; AGING; ANIMALS; ANTI-INFLAMMATORY AGENTS; BEHAVIOR, ANIMAL; CORTICOSTERONE; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY; RATS; RATS, INBRED F344; SPACE PERCEPTION; SWIMMING;

EID: 0033535832     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01310-4     Document Type: Article

References (30)

1. Barnes C.A., Green E.J., Baldwin J., Johnson W.E. Behavioral and neurophysiological examples of functional sparing in senescent rat. Can. J. Psychol. 41(2):1987;131-140.
2. Barnes C.A., McNaughton B.L. An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses. Behav. Neurosci. 99(6):1985;1040-1048.
3. Bodnoff S.R., Humphreys A.G., Lehman J.C., Diamond D.M., Rose G.M., Meaney M.J. Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats. J. Neurosci. 15(1):1995;61-69.
4. Dachir S., Kadar T., Robinzon B., Levy A. Cognitive deficits induced in young rats by long-term corticosterone administration. Behav. Neural Biol. 60:1993;103-109.
5. Deupree D.L., Bradley J., Turner D.A. Age-related alterations in potentiation in the CA1 region in F344 rats. Neurobiol. Aging. 14(3):1993;249-258.
6. Deupree D.L., Turner D.A., Watters C.L. Spatial performance correlates with in vitro potentiation in young and aged Fischer 344 rats. Brain Res. 554(1-2):1991;1-9.
7. Dunbar G.L., Rylett R.J., Schmidt B.M., Sinclair R.C., Williams L.R. Hippocampal choline acetyltransferase activity correlates with spatial learning in aged rats. Brain Res. 604(1-2):1993;266-272.
8. Fischer W., Chen K.S., Gage F.H., Bjorklund A. Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiol. Aging. 13:1991;9-23.
9. Fordyce D.E., Wehner J.M. Effects of aging on spatial learning and hippocampal protein kinase C in mice. Neurobiol. Aging. 14(4):1993;309-317.
10. Foster T.C., Barnes C.A., Rao G., McNaughton B.L. Increase in perforant path quantal size in aged f-344 rats. Neurobiol. Aging. 12:1991;441-448.
11. Gage F.H., Bjorklund A. Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism. J. Neurosci. 6(10):1986;2837-2847.
12. Gallagher M., Pelleymounter M.A. An age-related spatial learning deficit: choline uptake distinguishes 'impaired' and 'unimpaired' rats. Neurobiol. Aging. 9:1988;363-369.
13. Geinisman Y., deToledo-Morrell L., Morrell F. Aged rats need a preserved complement of perforated axospinous synapses per hippocampal neuron to maintain good spatial memory. Brain Res. 398(2):1986;266-275.
14. Hebda-Bauer E.K., Briones T., Therrien B. A visual cue enhanced by sound improves spatial learning and decreases responses to distraction in animals with hippocampal damage. Soc. Neurosci. Abstr. 20(2):1994;1014.
15. Issa A.M., Rowe W., Gauthier S., Meaney M.J. Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats. J. Neurosci. 10(10):1990;3247-3254.
16. Lipman R.D., Chrisp C.E., Hazzard D.G., Bronson R.T. Pathologic characterization of Brown Norway, Brown Norway×Fischer 344, and Fischer 344×Brown Norway Rats with Relation to Age. J. Gerontol. Biol. Sci. 51A(1):1996;B54-B59.
17. Luine V., Martinez C., Villegas M., Magarinos A.M., McEwen B.S. Restraint stress reversibly enhances spatial memory performance. Physiol. Behav. 59(1):1996;27-32.
18. Luine V., Villegas M., Martinez C., McEwen B.S. Repeated stress causes reversible impairments of spatial memory performance. Brain Res. 639:1994;167-170.
19. McEwen B.S., Stellar E. Stress and the individual: mechanisms leading to disease. Arch. Int. Med. 153:1993;2093-2101.
20. Morano M.I., Vazquez D.M., Akil H. The role of the hippocampal mineralocorticoid and glucocorticoid receptors in the hypothalamo-pituitary-adrenal axis of the aged fischer rat. Mol. Cel. Neurosci. 5:1994;400-412.
21. Odio M., Brodish A. Age-related adaptation of pituitary-adrenocortical responses to stress. Neuroendocrinology. 49:1989;382-388.
22. Sapolsky R.M., Krey L.C., McEwen B.S. The adrenocortical stress-response in the aged male rat: impairment of recovery from stress. Exp. Gerontol. 18:1983;55-64.
23. Sapolsky R.M., Krey L.C., McEwen B.S. Stress down-regulates corticosterone receptors in a site-specific manner in the brain. Endocrinology. 114(1):1985;287-292.
24. Sapolsky R.M., Krey L.C., McEwen B.S. Prolonged glucocorticoid exposure reduces hippocampal neuron number: Implications for aging. J. Neurosci. 5(5):1985;1222-1227.
25. Tanila H., Sipila P., Shapiro M., Eichenbaum H. Brain aging: impaired coding of novel environmental cues. J. Neurosci. 17(13):1997;5167-5174.
26. Therrien B., Holden J.E., Hebda-Bauer E.K. Effects of a cue and distracter on spatial learning after hippocampal damage: gender differences. Soc. Neurosci. Abstr. 19(1):1993;361.
27. Turner D.A., Deupree D.L. Functional elongation of CA1 hippocampal neurons with aging in Fischer 344 rats. Neurobiol. Aging. 12:1991;201-210.
28. Van Der Staay F., Blokland A. Behavioral differences between outbred Wistar, inbred Fischer 344, Brown Norway, and hybrid Fischer 344×Brown Norway rats. Phys. Behav. 60(1):1996;97-109.
29. Van Eekelen J.A.M., Rots N.Y., Sutanto W., De Kloet E.R. The effect of aging on stress responsiveness and central corticosteroid receptors in the brown norway rat. Neurobiol. Aging. 13:1991;159-170.
30. Young E.A., Vazquez D. Hypercortisolemia, hippocampal glucocorticoid receptors, and fast feedback. Mol. Psychiatry. 1:1996;149-159.