Neuropeptide Y inhibits glutamate release and long-term potentiation in rat dentate gyrus

Brain Research

Volumn 827, Issue 1-2, 1999, Pages 229-233

  Whittaker, Elizabeth ^a   Vereker, Emily ^a   Lynch, M A ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

c Jun activated protein kinase; Dentate gyrus; Glutamate release; Long term potentiation; Neuropeptide Y

Indexed keywords

GLUTAMIC ACID; NEUROPEPTIDE Y; STRESS ACTIVATED PROTEIN KINASE;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; HORMONE ACTION; LONG TERM POTENTIATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTOSOME;

ACTION POTENTIALS; ANIMALS; APPETITE STIMULANTS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DENTATE GYRUS; ENZYME ACTIVATION; GLUTAMIC ACID; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LONG-TERM POTENTIATION; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPEPTIDE Y; POTASSIUM CHLORIDE; PROTEIN KINASES; RATS; RATS, WISTAR; SYNAPSES; SYNAPTOSOMES;

EID: 0033535741     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01302-5     Document Type: Article

References (21)

1. Barecca A., Valli B., Casarone A., Arvigo M., Balasini, La Sala G., Garrone S., Minuto F., Giordano G. Effects of neuropeptide Y on estradiol and progesterone secretion by human granulosa cells in culture. Fertil. Steril. 70:1998;320-325.
2. Bliss T.V.P., Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361:1993;31-39.
3. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein dye binding. Anal Biochem. 72:1976;248-254.
4. Canevari L., Richter-Levin G., Bliss T.V.P. LTP in the dentate gyrus is associated with a persistent NMDA receptor-dependent enhancement of synaptosomal glutamate release. Brain Res. 667:1994;115-117.
5. Castagne V., Corder R., Gaillard R., Mormende P. Stress-induced changes of circulating neuropeptide Y in the rat: comparison with catecholamines. Regul. Pept. 19:1987;55-63.
6. Cleary J., Semotuk M., Levine A.S. Effects of neuropeptide Y on short-term memory. Brain Res. 653:1994;210-214.
7. Colmers W.F., Lukowiak K., Pittman Q.J. Presynaptic action of neuropeptide Y in area CA1 of the rat hippocampal slice. J. Physiol. (London). 383:1987;285-299.
8. Colmers W.F., Lukowiak K., Pittman Q.J. Neuropeptide Y action in the rat hippocampal slice: site and mechanism of presynaptic inhibition. J. Neurosci. 8:1988;3827-3837.
9. Davis R.J. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 271:1993;24329-24332.
10. Dumont Y., Fournier A., St-Pierre S., Quirion R. Comparative characterization and autoradiographic distribution of neuropeptide Y receptor subtypes in rat brain. J. Neurosci. 13:1993;73-86.
11. 5 receptor subtype in the rat brain. J. Neurosci. 18:1998;5565-5574.
12. 2 receptors in rat hippocampal slices in vitro. Br. J. Pharmacol. 113:1994;737-740.
13. Flood J.F., Morley J.E. Dissociation of the effects of neuropeptide Y on feeding and memory: evidence for pre- and post-synaptic mediation. Peptides. 10:1989;963-966.
14. Haan E.A., Bowen D.M. Protection of neocortical prisms from freeze-thaw injury by dimethylsulphoxide. J. Neurochem. 37:1981;243-246.
15. McCullough L.A., Egan T.M., Westfall T.C. Neuropeptide Y inhibition of calcium channels in PC-12 pheochromocytoma cells. Am. J. Physiol. 274:1998;C1290-1297.
16. McGahon B., Lynch M.A. The synergism between metabotropic glutamate receptor activation and arachidonic acid on glutamate release is occluded by induction of long-term potentiation in the dentate gyrus. Neuroscience. 72:1996;847-855.
17. McGahon B., Kelly A., Maguire C., Lynch M.A. Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3-dicarboxylate impacts on long-term potentiation in the dentate gyrus of the rat. Neuroscience. 90:1999;. in the press.
18. 2 receptors inhibit the frequency of spontaneous but not miniature EPSCs in CA3 pyramidal cells of rat hippocampus. J. Neurophysiol. 76:1996;3159-3168.
19. Nussdorfer G.G., Gottardo G. Neuropeptide Y family of peptides in the autocrine-paracrine regulation of adrenocortical function. Horm. Metab. Res. 30:1998;368-373.
20. Ordronneau P., Abdullah L., Petruse P. An efficient enzyme immunoassay for glutamate using glutaraldehyde coupling of the hapten to microtiter plates. J. Immunol. Methods. 142:1991;169-176.
21. Vereker E., Lynch M.A. Analysis of the effects of IL-1β on hippocampal function. Soc. Neurosci. Abstr. 24:1998;1972.