Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 3, 1999, Pages 459-462

  Sedrani, Richard ^a   Jones, Lyn H ^a   Jutzi Eme, Anne Marie ^a   Schuler, Walter ^a   Cottens, Sylvain ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Immunosuppressant; Natural product derivation; Rapamycin

Indexed keywords

IMMUNOPHILIN; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG MECHANISM; DRUG PROTEIN BINDING; STRUCTURE ACTIVITY RELATION;

CLONE CELLS; HYDROLYSIS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE CULTURE TEST, MIXED; SIROLIMUS;

EID: 0033535083     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00007-4     Document Type: Article

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