Structure-activity relationships of substituted 5H-thiazolo[3,2- a]pyrimidines as group 2 metabotropic glutamate receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 11, 1999, Pages 1573-1576

  Wichmann, Jürgen ^a   Adam, Geo ^a   Kolczewski, Sabine ^a   Mutel, Vincent ^a   Woltering, Thomas ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR ANTAGONIST; DIZOCILPINE; GLUTAMATE RECEPTOR ANTAGONIST; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); KAINIC ACID; KAINIC ACID RECEPTOR; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PYRIMIDINE DERIVATIVE; RO 48 8587; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CRICETINAE; EXCITATORY AMINO ACID ANTAGONISTS; KINETICS; MODELS, CHEMICAL; PYRIMIDINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0033532551     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00227-9     Document Type: Article

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