New indolines derivatives from strychnobrasiline, modulators of chloroquine resistance in Plasmodium falciparum

Tetrahedron

Volumn 55, Issue 19, 1999, Pages 6139-6146

  Trigalo, François ^a   Martin, Marie Thérèse ^b   Blond, Alain ^a   Brouard, Jean Paul ^a   Rafatro, Herintsoa ^c   Ramanitrahasimbola, David ^c   Frappier, François ^a  

^a EUROPEAN SPACE AGENCY   (France)

^b INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

^c INSTITUT MALGACHE DE RECHERCHES APPLIQUÉES   (Madagascar)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; INDOLE ALKALOID; MAGALASHANINE; PLANT EXTRACT; STRYCHNOBRASILINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG POTENTIATION; DRUG STRUCTURE; DRUG SYNTHESIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0033532014     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(99)00269-0     Document Type: Article

References (8)

1. Caira, M.R.; Rasoanaivo, P. J. Chem. Crystallogr. 1995, 25, 725-729.
2. Rasoanaivo, P. ; Ratsimamanga-Urverg, D. ; Milijaona, R. ; Rafatro, H. ; Ratsimamanga, A. ; Galeffi, C. ; Nicoletti, M. Planta Med. 1994; 6, 13-16.
3. Iwataki, J.; Comi, J. Tetrahedron 1971, 27, 2541-2552.
4. Martin MT, Frappier F, Rasoanaivo P, Randrianarivelojona M. Magn. Reson. Chem. 1996, 34, 489-493.
5. a)N-desacetyl strychnobrasiline, 1a, was obtained from 1 after 1N HCl treatment for 2h at 95°C in quantitative yield,
6. b) Rasoanaivo, P.; Galeffi, C.; deVincente, Y.; Nicoletti, M. Rev. Latinoam. Quim. 1991, 22, 32-34.
7. Chen, SC. Synthesis 1974, 691-703.
8. Frappier, F.; Jossang, A.; Soudon, J.; Calvo, F.; Rasoanaivo, P.; Ratsimamanga-Urverg, S.; Saez, J.; Grellier, P. Antimicrob. Agents Chemother. 1996, 40, 1476-1481.