Phomalairdenone: A new host-selective phytotoxin from a virulent type of the blackleg fungus Phoma lingam

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 23, 1999, Pages 3291-3294

  Pedras, M Soledade C ^a   Erosa López, Claudia C ^a   Quail, J Wilson ^a   Taylor, Janet L ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PHOMALAIRDENONE; PLANT TOXIN; SESQUITERPENE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; FUNGUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PHYTOTOXICITY;

EID: 0033530874     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00602-2     Document Type: Article

References (25)

1. Gugel, R. K.; Petrie, G. A. Can. J. Plant Pathol. 1992, 14, 36, and references therein.
2. Although no reclassification as occurred yet, overwhelming evidence suggests that blackleg disease may in fact be caused by a complex of Phoma species, including P. lingam and P. wasabiae. For an update on blackleg fungi see ref 5.
3. The so-called "highly virulent strain" causes leaf spots and severe stem cankers on rapeseed/canola (Brassica napus, B. rapa) and cabbage (B. oleracea).
4. The so-called "avirulent strain" causes only superficial leaf and stem lesions on rapeseed and cabbage.
5. For a recent review on blackleg metabolites see: Pedras, M. S. C. Recent Res. Devel. Agricult. Food Chem. 1998, 2, 513.
6. Keri, M.; Van den Berg, C. G. J.; McVetty, P. B. E.; Rimmer, S. R. Phytopathology, 1997, 87, 594.
7. "Canola- quality lines" refers to plants containing low levels of glucosinolates and erucic acid.
8. Taylor, J. L.; Pedras, M. S. C.; Morales, V. M. Trends Microbiol. 1995, 3, 202.
9. Chen, C. Y.; Howlett, B. J.; Plummer, K. M. Eur. J. Plant Pathol. 1996, 102, 349.
10. Pedras, M. S. C.; Smith, K. C.; Taylor, J. L. Phytochemistry 1998, 49, 1575.
11. Highly virulent isolates of P. lingam produce the host-selective toxin phomalide (1).
12. Pedras, M. S. C.; Morales, V. M.; Taylor, J. L. Phytochemistry 1994, 36, 1315.
13. 3CN) at a flow rate 1.0 mL/min.
14. r = 29.6 min, conditions as described above).
15. -1.
16. 2 > )) = 0.857; GoF = 1.024.
17. First isolation: Seto, H.; Yonehara, H. J. Antibiot. 1980, 33, 92. Biosynthetic studies, inter alia:
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