Intraperitoneal administration of anti-c-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein E-deficient mice

Circulation

Volumn 99, Issue 13, 1999, Pages 1740-1746

  Murayama, Toshinori ^b   Yokode, Masayuki ^a   Kataoka, Hiroshi ^b   Imabayashi, Takeshi ^b   Yoshida, Hiroyuki ^b   Sano, Hideto ^b   Nishikawa, Satomi ^b   Nishikawa, Shin Ichi ^b   Kita, Toru ^b  

^a KYOTO UNIVERSITY   (Japan)

^b NONE

Author keywords

Antibodies; Atherosclerosis; Leukocytes

Indexed keywords

APOLIPOPROTEIN E; COLONY STIMULATING FACTOR 1; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C FMS; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; FAT INTAKE; FLOW CYTOMETRY; HYPERLIPOPROTEINEMIA TYPE 3; IMAGE ANALYSIS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICROPHOTOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

EID: 0033528755     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.99.13.1740     Document Type: Article

References (38)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
2. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ. Atherosclerosis: basic mechanisms: oxidation, inflammation, and genetics. Circulation. 1995;91:2488-2496.
3. Libby P. Molecular bases of the acute coronary syndromes. Circulation. 1995;91:2844-2850.
4. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation. 1995;92:657-671.
5. Plump AS, Smith JD, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft JG, Rubin EM, Breslow JL. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343-353.
6. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468-471.
7. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. Apo E-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 1994;14:133-140.
8. Reddick RL, Zhang SH, Maeda N. Atherosclerosis in mice lacking apo E. Arterioscler Thromb. 1994;14:141-147.
9. van Ree JH, van den Broek WJAA, Dahlmans VEH, Groot PHE, Vidgeon-Hart M, Frants RR, Wieringa B, Havekes LM, Hofker MH. Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice. Atherosclerosis. 1994;111:25-37.
10. Breslow JL. Mouse models of atherosclerosis. Science. 1996;272: 685-688.
11. Tushinski RJ, Oliver IT, Guilbert LJ, Tynan PW, Warner JR, Stanley ER. Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy. Cell. 1982; 28:71-81.
12. Sherr CJ, Rettenmier CW, Roussel MF. Macrophage colony-stimulating factor. CSF-1, and its proto-oncogene-encoded receptor. Cold Spring Harb Symp Quant Biol. 1988;53:521-530.
13. Rosenfeld ME, Ylä-Herttuala S, Lipton BA, Ord VA, Witztum JL, Steinberg D. Macrophage colony-stimulating factor mRNA and protein in atherosclerotic lesions of rabbits and humans. Am J Pathol. 1992;140: 291-300.
14. Clinton SK, Underwood R, Hayes L, Sherman ML, Kufe DW, Libby P. Macrophage colony-stimulating factor gene expression in vascular cells and in experimental and human atherosclerosis. Am J Pathol. 1992;140: 301-316.
15. Inaba T, Yamada N, Gotoda T, Shimano H, Shimada M, Momomura K, Kadowaki T, Motoyoshi K, Tsukada T, Morisaki N, Saito Y, Yoshida S, Takaku F, Yazaki Y, Expression of M-CSF receptor encoded by c-fms on smooth muscle cells derived from atherosclerotic lesion. J Biol Chem. 1992;267:5693-5699.
16. Salomon RN, Underwood R, Doyle MV, Wang A, Libby P. Increased apolipoprotein E and c-fms gene expression without elevated interleukin 1 or 6 mRNA levels indicates selective activation of macrophage functions in advanced human atheroma. Proc Natl Acad Sci U S A. 1992;89:2814-2818.
17. Yoshida H, Hayashi S, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa S. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature. 1990;345:442-444.
18. Naito M, Hayashi S-I, Yoshida H, Nishikawa S-I, Shultz LD, Takahashi K. Abnormal differentiation of tissue macrophage populations in "osteopetrosis" (op) mice defective in the production of macrophage colony-stimulating factor. Am J Pathol. 1991;139:657-667.
19. Smith JD, Trogan E, Ginsberg M, Grigaux C, Tian J, Miyata M. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A. 1995;92:8264-8268.
20. Quiao J-H, Tripathi J, Mishra NK, Cai Y, Tripathi S, Wang X-P, Imes S, Fishbein MC, Clinton SK, Libby P, Lusis AJ, Rajavashisth TB. Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice. Am J Pathol. 1997;150:1687-1699.
21. Wiktor-Jedrzejczak W, Ahmed A, Szczylik C, Skelly RR. Hematological characterization of congenital osteopetrosis in op/op mouse. J Exp Med. 1982;156:1516-1527.
22. Inoue I, Inaba T, Motoyoshi K, Harada K, Shimano H, Kawamura M, Gotoda T, Oka T, Shiomi M, Watanabe Y, Tsukada T, Yazaki Y, Takaku F, Yamada N. Macrophage colony stimulating factor prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits. Atherosclerosis. 1992;93:245-254.
23. Sudo T, Nishikawa S, Ogawa M, Kataoka H, Ohno N, Izawa A, Hayashi S-I, Nishikawa S-I. Functional hierarchy of c-kit and c-fms in intra-marrow production of CFU-M. Oncogene. 1995;11:2469-2476.
24. Paigen B, Morrow A, Holmes PA, Mitchell D, Williams RA. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis. 1987;68: 231-240.
25. Plump AS, Scott CJ, Breslow JL. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A. 1994;91:9607-9611.
26. Pászty C, Maeda N, Verstuyft J, Rubin EM. Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J Clin Invest. 1994;94:899-903.
27. Gupta S, Pablo AM, Jiang X-C, Wang N, Tall AR, Schindler C. IFN-γ potentiates atherosclerosis in apoE knock-out mice. J Clin Invest. 1997; 99:2752-2761.
28. Suzuki H, Kurihara Y, Takeya M, Kameda N, Kataoka M, Jishaga K, Ueda O, Sakaguchi H, Higashi T, Suzuki T, Takashima Y, Kawabe Y, Cynshi O, Wada Y, Honda M, Kurihara H, Aburatani H, Doi T, Matsumoto A, Azuma S, Noda T, Toyoda Y, Itakura H, Yazaki Y, Horiuchi S, Takahashi K, Kruijt JK, van Berkel TJC, Steinbrecher UP, Ishibashi S, Maeda N, Gordon S, Kodama T. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature. 1997;386:292-296.
29. Mezdour H, Jones R, Dengremount C, Castro G, Maeda N. Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem. 1997;272: 13570-13575.
30. Dansky HM, Charlton SA, McGee Harper M, Smith JD. T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse. Proc Natl Acad Sci U S A. 1997;94: 4642-4646.
31. Daugherty A, Puré E, Delfel-Butteiger D, Chen S, Leferovich J, Roselaar SE, Rader DJ. The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/-mice. J Clin Invest. 1997;100: 1575-1580.
32. Wang JM, Griffin JD, Rambaldi A, Chen ZG, Mantovani A. Induction of monocyte migration by recombinant macrophage colony-stimulating factor. J Immunol. 1988;141:575-579.
33. Shyy Y-J, Wickham LL, Hagan JP, Hsieh H-J, Hu Y-L, Telian SH, Valente AJ, Paul Sung K-L, Chien S. Human monocyte colony-stimulating factor stimulates the gene expression of monocyte chemotactic protein-1 and increases the adhesion of monocytes to endothelial monolayers. J Clin Invest. 1993;92:1745-1751.
34. Rajavashisth TB, Andalibi A, Territo MC, Berliner JA, Navab M, Fogelman AM, Lusis AJ. Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins. Nature. 1990;344:254-257.
35. Rajavashisth TB, Yamada H, Mishra NK. Transcriptional activation of the macrophage-colony stimulating factor gene by minimally modified LDL. Arterioscler Thromb Vasc Biol. 1995;15:1591-1598.
36. Tangirala RK, Rubin EM, Palinski W. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J Lipid Res. 1995; 36:2320-2328.
37. Nakashima Y, Raines EW, Plump AS, Breslow JL, Ross R. Upregulation of VCAM-1 and ICAM-1 at atherosclerosis-prone sites on the endothelium in the apoE-deficient mice. Arterioscler Thromb Vasc Biol. 1998; 18:842-851.
38. Rajavashisth T, Quiao J-H, Tripathi S, Tripathi J, Mishra N, Hua M, Wang X-P, Loussararian A, Clinton S, Libby P, Lusis A. Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 1998;101:2702-2710.