The roles of Glu-327 and His-446 in the bisphosphatase reaction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase probed by NMR spectroscopic and mutational analyses of the enzyme in the transient phosphohistidine intermediate complex

Biochemistry

Volumn 38, Issue 14, 1999, Pages 4471-4479

  Okar, David A ^a   Live, David H ^a   Kirby, Tara L ^a   Karschnia, Elizabeth J ^a   Von Weymarn, Linda B ^a   Armitage, Ian M ^a   Lange, Alex J ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; FRUCTOSE 2,6 BISPHOSPHATASE; HISTIDINE DERIVATIVE; PHOSPHATASE;

ANIMAL TISSUE; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME MECHANISM; LIVER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ALANINE; ANIMALS; DNA MUTATIONAL ANALYSIS; FRUCTOSE-BISPHOSPHATASE; GLUTAMIC ACID; HISTIDINE; HYDROGEN-ION CONCENTRATION; KINETICS; LIVER; MALE; MULTIENZYME COMPLEXES; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHOFRUCTOKINASE-1; PHOSPHOFRUCTOKINASE-2; RATS; TESTIS; TITRIMETRY;

ANIMALIA;

EID: 0033528742     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9828728     Document Type: Article

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