Synthesis and antibacterial properties of β-diketone acrylate bioisosteres of pseudomonic acid A

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 13, 1999, Pages 1847-1852

  Bennett, Isobel ^a   Broom, Nigel J P ^a   Cassels, Robert ^a   Elder, John S ^a   Masson, Nicky D ^a   O'Hanlon, Peter J ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIKETONE; ACRYLIC ACID DERIVATIVE; ANTIINFECTIVE AGENT; DIKETONE; ISOLEUCINE TRANSFER RNA LIGASE; PSEUDOMONIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BIOISOSTERE; CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ENZYME INHIBITION; HAEMOPHILUS INFLUENZAE; MINIMUM INHIBITORY CONCENTRATION; MORAXELLA CATARRHALIS; MOUSE; NONHUMAN; PHARMACOKINETICS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTI-BACTERIAL AGENTS; KETONES; KINETICS; MALE; MICE; MUPIROCIN; STAPHYLOCOCCUS AUREUS;

EID: 0033526883     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00296-6     Document Type: Article

References (7)

1. 1. Fuller, A. T.; Mellows, G.; Woolford, M.; Banks, G. T.; Barrow, K. D.; Chain, E. B. Nature 1971, 234, 416-417.
2. 2. Hughes, J.; Mellows, G. Biochem. J. 1980, 191, 209-219.
3. 3. Mellows, G. In Bactroban; Proceedings of an International Symposium; Dobson, R. L., Ed.; Excerpta Medica: Amsterdam, 1985; pp3-10.
4. 4. Broom, N. J. P.; Elder, J. S.; Hannan, P. C. T.; O'Hanlon, P. J.; Pons, J. E.; Wilson, J. M.; Walker, G.; Woodall, P. J. Antibiot. 1995, 48, 1336-1344.
5. 5. Brown, P.; Best, D. J.; Broom, N. J. P.; Cassels, R.; O'Hanlon, P. J.; Mitchell, T. J.; Osborne, N. F.; Wilson, J. W. J. Med. Chem. 1997, 40, 2563-2570.
6. 6. Alexander, R. G.; Clayton, J.P.; Luk, K.; Rogers, N. H. J. Chem. Soc., Perkin Trans. 1 1978, 561-567.
7. 7. Abson, A.; Broom, N. J. P.; Coates, P. A.; Elder, J. S.; Forrest, A. K.; Hannan, P. C. T.; Hicks, A. J.; O'Hanlon, P. J.; Masson, N. D.; Pearson, N. D.; Pons, J. E.; Wilson, J. W. J. Antibiot. 1996, 49, 390-394.