The gene mod(mdg4) affects synapse specificity and structure in Drosophila

Journal of Neurobiology

Volumn 39, Issue 3, 1999, Pages 447-460

  Gorczyca, Michael ^a   Popova, Evgenya ^a   Jia, Xi Xi ^a   Budnik, Vivian ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Body wall muscles; BTB motif; Cell adhesion; Chromatin regulator gene; Mutant; Neuromuscular junction; P element mutagenesis; Subsynaptic reticulum; Synaptic bouton; Transcription factor

Indexed keywords

ARTICLE; DROSOPHILA; GENE CONTROL; GENE MUTATION; GENETIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL; SYNAPSE; ULTRASTRUCTURE;

ALLELES; ANIMALS; DROSOPHILA; DROSOPHILA PROTEINS; GENES; MOTOR NEURONS; MUSCLES; MUTATION; NERVOUS SYSTEM PHYSIOLOGY; SYNAPSES; TRANSCRIPTION FACTORS;

EID: 0033526536     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4695(19990605)39:3<447::AID-NEU10>3.0.CO;2-Q     Document Type: Article

References (42)

1. Azpiazu N, Frasch M. 1993. tinman and bagpipe: two homeobox genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev 7:1325-1340.
2. Bailey CH, Montarolo PG, Chen M, Kandel ER, Schacher S. 1992. Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia. Neuron 9:749-758.
3. Bailey CH, Bartsch D, Kandel ER. 1996. Towards a molecular definition of long-term memory storage. Proc Natl Acad Sci USA 93:13445-13452.
4. Bier E, Vaessin H, Shepherd S, Lee K, McCall K, Barbel S, Acherman L, Carretto R, Uemura T, Grell E, Jan LY, Jan YN. 1989. Searching for pattern and mutations in the Drosophila genome with a P element LacZ vector. Genes Dev 3:1273-1287.
5. Budnik V. 1996. Synapse maturation and structural plasticity at Drosophila neuromuscular junctions. Curr Opin Neurobiol 6:858-867.
6. Budnik V, Gorczyca M. 1992. SSB, an antigen that selectively labels morphologically distinct synaptic boutons at the Drosophila larval neuromuscular junction. J Neurobiol 23:1054-1066.
7. Budnik V, Koh Y-H, Guan B, Haugh C, Woods D, Gorezyca M. 1996. Regulation of synapse structure and function by the Drosophila tumor suppressor gene, dlg. Neuron 17:627-640.
8. Budnik V, Zhong Y, Wu C-F. 1990. Morphological plasticity of motor axon terminals in Drosophila mutant with altered excitability. J Neurosci 10:3754-3768.
9. Chiba A, Snow P, Keshishian H, Hotta Y. 1995. Fasciclin III as a synaptic target recognition molecule in Drosophila. Nature 374:166-168.
10. Crossley CA. 1978. The morphology and development of the Drosophila muscular system. In: M. Ashburner, T. R. F. Wright, editors. The genetics and biology of Drosophila. Vol. 2b. New York: Academic Press, p. 526-531.
11. Davis GW, Schuster CM, Goodman CS. 1997. Genetic analysis of the mechanisms controlling target selection: target derived Fasciclin II regulates the pattern of synapse formation. Neuron 19:561-573.
12. Dorn R, Krauss V, Reuter G, Saumweber H. 1993. The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators. Proc Natl Acad Sci USA 90:11376-11380.
13. Gerasimova TI, Corces VG. 1998. Polycomb and Trithorax group proteins mediate the function of a chromatin insulator. Cell 92:511-521.
14. Gerasimova TI, Gdula DA, Gerasimov DV, Simonova O, Corces VG. 1995. A Drosophila protein that imparts directionality on a chromatin insulator is an enhancer of position-effect variegation. Cell 82:587-597.
15. Giniger E, Tietje K, Jan LY, Jan YN. 1994. lola encodes a putative transcription factor required for axon growth and guidance in Drosophila. Development 120:1385-1398.
16. Gorczyca MG, Augart C, Budnik V. 1993. Insulin-like receptor and insulin-like peptide are localized at neuromuscular junctions in Drosophila. J Neurosci 13:3692-3704.
17. Gorczyca MG, Phillis RW, Budnik V. 1994. The role of tinman, a mesodermal cell fate gene, in axon pathfinding during the development of the transverse nerve in Drosophila. Development 120:2143-2152.
18. Grenningloh G, Rehm EJ, Goodman CS. 1991. Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule. Cell 67:45-57.
19. Guan B, Hartmann B, Koh Y-H, Gorczyca M, Budnik V. 1996. The Drosophila tumor suppressor gene, dlg, is involved in structural plasticity at a glutamatergic synapse. Curr Biol 6:695-706.
20. Hall ZW, Sanes JR. 1993. Synaptic structure and development: the neuromuscular junction. Neuron 10(Suppl):99-121.
21. Hu S, Fambrough D, Atashi JR, Goodman CS, Crews ST. 1995. The Drosophila abrupt gene encodes a BTB-zinc finger regulatory protein that controls the specificity of neuromuscular connections. Genes Dev 9:2936-2948.
22. Jan LY, Jan YN. 1982. Antibodies to horseradish peroxidase as specific neuronal markers in Drosophila and grasshopper embryos. Proc Natl Acad Sci USA 72:2700-2704.
23. Jia X, Gorczyca M, Budnik V. 1993. Ultrastructure of neuromuscular junctions in Drosophila: comparison of wild type and mutants with increased excitability. J Neurobiol 24:1025-1044.
24. Johansen J, Halpern ME, Johansen KM, Keshishian H. 1989a. Stereotypic morphology of glutamatergic synapses on identified muscle cells of Drosophila larvae. J Neurosci 9:710-725.
25. Johansen J, Halpern ME, Keshishian H. 1989b. Axonal guidance and the development of muscle fiber specific innervation in Drosophila embryos. J Neurosci 9:4318-4332.
26. Keshishian H, Broadie K, Chiba A, Bate M. 1996. The Drosophila neuromuscular junction: a model system for studying synaptic development and function. Annu Rev Neurosci 19:545-575.
27. Lahey T, Gorczyca M, Jia X, Budnik V. 1994. The Drosophila tumor suppressor gene dig is required for normal synaptic bouton structure. Neuron 13:823-835.
28. Monastirioti M, Gorczyca M, Rapus J, Eckert M, White K, Budnik V. 1995. Octopamine immunoreactivity in the fruit fly Drosophila melanogaster. J Comp Neurol 356: 275-287.
29. Petruzzelli L, Herrera R, Arenas-García R, Fernandez R, Birnbaum MJ, Rosen OM. 1986. Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody. Proc Natl Acad Sci USA 83:4710-4714.
30. Phillis RW, Bramlage AT, Wotus CW, Whittaker A, Gramates LS, Seppala D, Farahanchi F, Caruccio P, Murphey RK. 1993. Isolation of mutations affecting neural circuitry required for grooming behavior in Drosophila melanogaster. Genetics 133:581-592.
31. Pirotta V. 1988. Vectors for P-mediated transformation in Drosophila. Biotechnology 10:437-456.
32. Pirotta V. 1997. Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression. Trends Genet 13:314-318.
33. Robertson HM, Preston CR, Phillis RW, Johnson-Schlitz D, Benz WK, Engels WR. 1988. A stable genomic source of P element transposase in Drosophila melanogaster. Genetics 118:461-470.
34. Rose D, Zhu X, Koe H, Hoang B, Cho J, Chiba A. 1997. Toll, a muscle cell surface molecule, locally inhibits synaptic initiation of the RP3 motorneuron growth cone in Drosophila. Development 124:1561-1571.
35. Schuster CM, Davis GW, Fetter RD, Goodman CS. 1996. Genetic dissection of structural and functional components of synaptic plasticity. I. Fasciclin II controls synaptic stabilization and growth. Neuron 17:641-654.
36. Shishido E, Takeichi M, Nose A. 1998. Drosophila synapse formation: regulation by transmembrane protein with leurich repeats, CAPRICIOUS. Science 280:2118-2121.
37. Tessier-Lavigne M, Goodman CS. 1996. The molecular biology of axon guidance. Science 274:1123-1133.
38. Thomas U, Kim E, Kuhlendahl S, Koh Y-H, Gundelfinger ED, Sheng M, Garner CC, Budnik V. 1997. Determination of synaptic bouton structure by discs-large dependent clustering of the cell adhesion molecule Fasciclin II. Neuron 19:787-799.
39. Van Vactor D, Sink H, Frambrough D, Tsoo R, Goodman CS. 1993. Genes that control neuromuscular specificity in Drosophila. Cell 73:1137-1153.
40. Woods DF, Bryant PJ. 1991. The disc-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 66:451-464.
41. Zito K Fetter RD, Goodman CS, Isacoff EY 1997. Synaptic clustering of Fascilin II and Shaker: essential targeting sequences and role of Dlg. Neuron 19:1007-1016.
42. Zollman S, Godt D, Privé GG, Couderc J-L, Laski FA. 1994. The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc Natl Acad Sci USA 91:10717-10721.