Analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole as potential antibacterial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 7, 1999, Pages 1023-1028

  Antolini, Marinella ^a   Bozzoli, Andrea ^a   Ghiron, Chiara ^a   Kennedy, Gordon ^a   Rossi, Tino ^a   Ursini, Antonella ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,5 BIS(3,5 DICHLOROPHENYL) 2 TRIFLUOROMETHYL 1H IMIDAZOLE; ANTIINFECTIVE AGENT; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; ESCHERICHIA COLI; IMIDAZOLES; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

EID: 0033526026     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00112-2     Document Type: Article

References (15)

1. 1. Neu H. C., Science, 1992, 257, 1073; Niccolai, D., Tarsi, L., Thomas, R. J., Chem. Commun. (Cambridge), 1997, 2333-2342.
2. 1. Neu H. C., Science, 1992, 257, 1073; Niccolai, D., Tarsi, L., Thomas, R. J., Chem. Commun. (Cambridge), 1997, 2333-2342.
3. 2. M. J. Cerelli, D. L. Curtis, J. P. Dunn, P. H. Nelson, T. H. Peak, D. Waterbury, J. Med. Chem., 1986, 29, 2347
4. 3. T. T. Tidwell, Org. React., 1990, 39, 297 N. Kornblum, J. W. Powers, G. J. Anderson, W. J. Jones, H. O. Larson, O. Levand, W. M. Weaver, J. Am. Chem. Soc., 1957, 79, 6562
5. 3. T. T. Tidwell, Org. React., 1990, 39, 297 N. Kornblum, J. W. Powers, G. J. Anderson, W. J. Jones, H. O. Larson, O. Levand, W. M. Weaver, J. Am. Chem. Soc., 1957, 79, 6562
6. 4. Strzybny, P. P. E., Van Es, T., Backeberg, O. G., J. S. African Chem. Inst., 1969, 22, 158
7. 5. Seko, N., Kohichiro, Y., Yokota, K., Tsukamoto, G., Chem. Pharm. Bull., 1991, 39, 651
8. 6. Curtis, N. J., Brown, R. S., J. Org. Chem., 1980, 45, 4035; Ngochindo, R. I., J. Chem. Soc. Perkin Trans. I., 1990, 1645
9. 6. Curtis, N. J., Brown, R. S., J. Org. Chem., 1980, 45, 4035; Ngochindo, R. I., J. Chem. Soc. Perkin Trans. I., 1990, 1645
10. 7. Shuranin, Yu. A., J. Org. Chem. USSR (Engl. Trans.), 1980, 16, 1861
11. 8. I. J. Turchi, M. J. S. Dewar, Chem. Rev., 1975, 75, 389
12. 9. Harris, N. V., Bridge, A. W., Bush, R. C., Coffee, E. C. J, Dron, D. I., Harper, M. F., Ashton, M. J., Lythgoe, D. J., Smith, C., et al., J. Med. Chem., 1992, 35, 4384-92 Green, D. L. C., Kiddle, J. J., Thompson, C. M., Tetrahedron, 1995, 51, 2865
13. 9. Harris, N. V., Bridge, A. W., Bush, R. C., Coffee, E. C. J, Dron, D. I., Harper, M. F., Ashton, M. J., Lythgoe, D. J., Smith, C., et al., J. Med. Chem., 1992, 35, 4384-92 Green, D. L. C., Kiddle, J. J., Thompson, C. M., Tetrahedron, 1995, 51, 2865
14. 10. National Committee for Clinical Laboratory Standards, 1993, v10(8), M7-A3
15. 11. B. Cavarelli, G. Volpe, V. Arioli, F. Parenti, Arzneim.-Forschl., 1977, 27, 1889