Enhanced immunogenicity of hepatitis B surface antigen by insertion of a helper T cell epitope from tetanus toxoid

Vaccine

Volumn 17, Issue 9-10, 1999, Pages 1035-1041

  Chengalvala, Murty V ^a   Bhat, Ramesh A ^a   Bhat, Bheem M ^a   Vernon, Steven K ^a   Lubeck, Michael D ^a  

^a WYETH AYERST RESEARCH   (United States)

Author keywords

Epitopic Suppression; Hepatitis B; T cell B cell collaboration; Vaccination

Indexed keywords

CHIMERIC PROTEIN; EPITOPE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B VACCINE; TETANUS TOXOID;

ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; FEMALE; HELPER CELL; HEPATITIS B; HEPATITIS B VIRUS; IMMUNOGENICITY; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE; VACCINATION; VIRUS HEPATITIS;

ANIMALS; EPITOPES, T-LYMPHOCYTE; FEMALE; HEPATITIS B SURFACE ANTIGENS; HUMANS; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, HELPER-INDUCER; TETANUS TOXOID; TUMOR CELLS, CULTURED;

EID: 0033525803     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00318-1     Document Type: Article

References (33)

1. Szmuness W. Hepatocellular carcinoma and the hepatitis B virus: evidence for a casual association. Prog Med Virol. 24:1978;40-69.
2. Ellis R.W. 1990. New and improved vaccines against hepatitis B. In: New Generation Vaccines. Woodrow G, Levine M, editors. New York: Mercel Dekker Inc. p. 439-447.
3. Brown S.E., Stanley C., Howard C.R., Zuckerman A.J., Steward M.W. Antibody responses to recombinant and plasma derived hepatitis B vaccines. Br Med J. 292:1986;159-161.
4. Scolnick E.M., McLean A.A., West D.J., McAleer W.J., Miller W.J., Buynak E.B. Clinical valuation in healthy adults of a hepatitis B vaccine made by recombinant DNA. J Am Med Assoc. 251:1984;2812-2815.
5. Crosnier J., Jungers P., Courouce A.M., Laplanche A., Benhamou E., Degos F., Lacour B., Prunet P., Cerisier Y., Guesry P. Randomized placebo-controlled trial of hepatitis B surface antigen vaccine in French haemodialysis units: II, haemodialysis patients. Lancet. I:1981;797-800.
6. Lelie P.N., Reesink H.W., Manen S.T., Dees P.J., Brongers E.E. Immune response to heat-inactivated hepatitis B vaccine in patients undergoing hemodialysis. Enhancement of the response by increasing the dose of hepatitis B surface antigen from 3 to 27 micrograms. Arch Intern Med. 145:1985;305-309.
7. Degos F., Duhamer G., Brechot C., Nalpas B., Courouce A.M., Tron F., Berthelot P. Hepatitis B vaccination in chronic alcoholics. J Hepatol. 2:1986;402-409.
8. Menderhall C., Roselle G.A., Lybecker L.A., Marshall L.E., Grossman C.J., Myre S.A. Hepatitis B vaccination. Response of alcoholics with and without liver injury. Dig Dis Sc. 33:1988;263-269.
9. Hess G., Rossol S., Voth R., Cheatham-Speth D., Clemens R., Meyer Zum Buschenfelde K.M. Active immunization of homosexual men using a recombinant hepatitis B vaccine. J Med Virol. 29:1989;229-231.
10. Hauser P., Voet P., Simoen E., Thomas H.C., Petre J., De Wilde M., Stephenne J. Immunological properties of recombinant HBsAg produced in yeast. Postgraduate Med J. 83:(91):1987.
11. Pillot J., Poynard T., Elias A., Maillard J., Lazizi Y., Brancer M., Dubreuil P., Budkowska A., Chaput J.C. Weak immunogenicity of the preS2 sequence and lack of circumventing effect on the unresponsiveness to the hepatitis B virus vaccine. Vaccine; 13:94 -289.
12. Schutze M.P., Leclerc C., Jolivet M., Audibert F., Chedid L.J. Carrier induced epitopic suppression, a major issue for future synthetic vaccines. J Immunol. 135:1985;2319-2322.
13. Herzenberg L.A., Tokuhisa T., Herzenberg L.A. Carrier priming leads to hapten-specific suppression. Nature. 285:1980;664-667.
14. Herzenberg L.A., Tokuhisa T. Epitope-specific induction of suppression for IgG anti-hapten antibody response. J Exp Med. 155:1982;1730-1740.
15. Schutze M.P., Leclerc C., Vogel F.R., Chedid L. Epitopic suppression in synthetic vaccine models: analysis of the effector mechanisms. Cell Immunol. 104:1987;79-90.
16. Tagawa M., Tokuhisa T., Ono K., Taniguchi M., Herzenberg L.A., Herzenberg L.A. Epitope specific regulation. IV. In Vitro studies with suppressor T cells induced by carrier/hapten-carrier immunization. Cell Immunol. 86:1984;327-336.
17. Sercarz E.E., Yowell R.L., Turkin D., Miller A., Araneo B.A., Adorini L. Different functional specificity repertoires for suppressor and helper T cells. Immunol Rev. 39:1978;108-136.
18. Adorini L., Harvey M.A., Miller A., Sercarz E.E. Fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme in a genetically nonresponder mouse strain. J Exp Med. 150:1979;293-306.
19. Etlinger H.M., Gillssen D., Lahn H.W., Matile H., Schonfeld H.J., Trzeciak A. Use of prior vaccinations for the development of new vaccines. Science (USA). 249:1990;423-425.
20. Delpeyronx F., Van Wezel E., Blondel B., Carinic R. Structural factors modulate the activity of antigenic poliovirus sequences expressed on hybrid hepatitis B surface antigen particles. J Virol. 64:1990;6090-6100.
21. Chengalvala M.V., Bhat B.M., Bhat R.A., Lubeck M.D., Mizutani S., Davis A., Hung P.P. Immunogenicity of high expression adenovirus-hepatitis B virus recombinant vaccines in dogs. J Gen Virol. 75:1994;125-131.
22. Chengalvala M.V., Bhat B.M., Bhat R.A., Dheer S.K., Lubeck M.D., Purcell R.H., Murthy K.K. Replication and immunogenicity of Ad7-, Ad4-, and Ad5-hepatitis B virus surface antigen recombinants, with or without a portion of E3 region, in chimpanzees. Vaccine. 15:1997;335-339.
23. Molnar-Kimber K.L., Jarocki-Witek V., Dheer S.K., Vernon S.K., Conley A.J., Davis A.R., Hung P.P. Distinctive properties of the hepatitis B virus envelope proteins. J Virol. 62:1988;407-416.
24. Maupas P., Coursaget P., Goudeau A., Drucker J., Bagros P. Immunization against hepatitis B in man. Lancet. 1:1976;1367-1370.
25. Milich D.R. Synthetic T and B cell recognition sites: implications for vaccine development. Advances in Immunology. 45:1989;195-264.
26. Milich D.R. T- and B-cell recognition of hepatitis B viral antigens. Immunology Today. 9:1988;380-386.
27. Berzofsky J.A. Ir Genes: antigen-specific genetic regulation of the immune response. The Antigens. 7:1987;1-113.
28. Owens T. A role for adhesion molecules in contact dependent T help for B cells. Eur J Immunol. 21:1991;979-983.
29. Lamb J.R., Ivanyi J., Rees A.D.M., Rothbard J.B., Howland K., Young R.A., Young D.B. Mapping of T cell epitopes using recombinant antigens and synthetic peptides. EMBO Journal. 6:1987;1245-1249.
30. Perlmutter R.M. T cell signaling. Science (USA). 245:1989;344-346.
31. Cardell S., Sander B., Moller G. Helper interleukins are produced by both CD4 and CD8 splenic T cells after mitogen stimulation. Eur J Immunol. 21:1991;2495-2500.
32. Sinigaglia F., Guttinger M., Kilgus J., Doran D.M., Matile H., Etlinger H., Trzeciak A., Gillessen O., Pink J.R.L. A malaria T cell epitope recognized in association with most mouse and human class II molecules. Nature. 336:1988;778-780.
33. Partidos C.D., Steward M.W. Prediction and identification of a T cell epitope in the fusion protein of measles virus immunodominant in mice and humans. J Gen Virol. 71:1990;2099-2105.