Dose dependency of antibody response in infants and children to pneumococcal polysaccharides conjugated to tetanus toxoid

Vaccine

Volumn 17, Issue 20-21, 1999, Pages 2726-2732

  Åhman, Heidi ^a   Käyhty, Helena ^a   Vuorela, Arja ^a   Leroy, Odile ^b   Eskola, Juhani ^b  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b Pasteur Mérieux Connaught ^*  (France)

Author keywords

Dose dependency; Infants; Pneumococcal tetanus toxoid conjugate vaccine

Indexed keywords

DIPHTHERIA PERTUSSIS TETANUS VACCINE; HAEMOPHILUS INFLUENZAE TYPE B VACCINE; HEXACYCLINE; INACTIVATED VACCINE; MEASLES MUMPS RUBELLA VACCINE; PNEUMOCOCCUS POLYSACCHARIDE; PNEUMOCOCCUS VACCINE; POLIOMYELITIS VACCINE; TETANUS TOXOID;

ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; DOSE RESPONSE; DRUG CONJUGATION; HUMAN; IMMUNIZATION; INFANT; INFANT DISEASE; MAJOR CLINICAL STUDY; MEMORY CELL; PRIORITY JOURNAL; STREPTOCOCCUS INFECTION;

ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HUMANS; IMMUNIZATION, SECONDARY; IMMUNOLOGIC MEMORY; INFANT; PNEUMOCOCCAL VACCINES; STREPTOCOCCUS PNEUMONIAE; TETANUS TOXOID; VACCINES, CONJUGATE;

EID: 0033523047     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00048-1     Document Type: Article

References (17)

1. Musher D.M., Chapman A.J., Coree A., Briles O., Baughn R.E. Natural and vaccine-related immunity to Streptococcus pneumoniae. J Infect Dis. 154:1986;245-256.
2. Siber G.R., Thompson C., Reid G.R., Almaido-Hill J., Zacher B., Wolff M., Santosham M. Evaluation of bacterial polysaccharide immune globulin for the treatment or prevention of Haemophilus influenzae type b and pneumococcal disease. J Infect Dis. 165(Suppl. 1):1992;S129-133.
3. Shurin P.A., Rehmus J.M., Johnson C.E., Marchant C.P., Carlin S.A., Super D.M., Van Hare G.F., Jones P.K., Ambrosino D.M., Siber G.R. Bacterial polysaccharide immune globulin for prophylaxis of acute otitis media in high-risk children. J Pediatr. 123:1993;801-810.
4. Douglas R.M., Paton J.C., Duncan S.J., Hansman D.J. Antibody responses to pneumococcal vaccination in children younger than five years of age. J Infect Dis. 148:1983;131-137.
5. Leinonen M., Säkkinen A., Kalliokoski R., Luotonen J., Timonen M., Mäkelä P.H. Antibody response to 14-valent pneumococcal capsular polysaccharide vaccine in preschool age children. Pediatr Infect Dis J. 5:1986;39-44.
6. Käyhty H., Åhman H., Rönnberg P.-R., Tillikainen R., Eskola J. Pneumococcal polysaccharide-meningococcal outer membrane protein complex conjugate vaccine is immunogenic in infants and children. J Infect Dis. 172:1995;1273-1278.
7. Anderson E., Kennedy D., Geldmacher K., Donelly J., Mendelman P. Immunogenicity of heptavalent pneumococcal conjugate vaccine in infants. J Pediatr. 128:1996;649-653.
8. Åhman H., Käyhty H., Tamminen P., Vuorela A., Malinoski F., Eskola J. Pentavalent pneumococcal oligosaccharide conjugate vaccine PncCRM is well-tolerated and able to induce an antibody response in infants. Pediatr Infect Dis J. 15:1996;134-139.
9. Leach A., Ceesay S., Banya W., Greenwood B. Pilot trial of a pentavalent pneumococcal polysaccharide/protein conjugate vaccine in Gambian infants. Pediatr Infect Dis J. 15:1996;333-339.
10. 197 conjugate vaccines: effect of saccharide size on immunogenicity and interactions with simultaneously administered HbOC and DTP vaccines. J Infect Dis. 176:1997;445-455.
11. Dagan R., Melamed R., Zamir O., Leroy O. Safety and immunogenicity of tetravalent pneumococcal vaccines containing 6B, 14 19F and 23F polysaccharides conjugated to either tetanus toxoid or diphtheria toxoid in young infants and their boosterability by native polysaccharide antigens. Pediatr Infect Dis J. 16:1997;1053-1059.
12. Åhman H., Käyhty H., Lehtonen H., Leroy O., Froeschle J., Eskola J. Streptococcus pneumoniae capsular polysaccharide - diphtheria toxoid conjugate vaccine is immunogenic in early infancy and able to induce immunologic memory. Pediatr Infect Dis J. 17:1998;211-216.
13. Sigurdardottir S., Vidarsson G., Gudnason T., Kjartansson S., Kristinsson K.G., Jonsson S., Valdimarsson H., Schiffman G., Schneerson R., Jonsdottir I. Immune responses of infants vaccinated with serotype 6B pneumococcal polysaccharide conjugated with tetanus toxoid. Pediatr Infect Dis J. 16:1997;667-674.
14. Dagan R, Eskola J, Leroy O, Bailleux F. Reduced response to multiple vaccines sharing common protein epitopes that are administered simultaneously to infants. Infect Immun 1998;66:2093-8.
15. Quataert S.A., Kirch C.S., Quackenbush Wiedl L.J., Phipps D.C., Strohmeyer S., Cimino C., Skuse J., Madore D.V. Assignment of weight-based antibody units to a human antipneumococcal standard reference serum, Lot 89-S. Clin Diagn Lab Immunol. 2:1995;590-597.
16. Peeters C., Tenbergen-Meekes A.-M., Poolman J., Beurret M., Zegers B., Rijkers G. Effect of carrier priming on immunogenicity of saccharide-protein conjugate vaccines. Infect Immun. 59:1991;3504-3510.
17. Insel R.A. Potential alterations in immunogenicity by combining or simultaneously administering vaccine components. Ann N Y Acad Sci. 754:1995;35-47.