Binding of fatty acid ethyl esters to albumin for transport to cells in culture

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1436, Issue 3, 1999, Pages 491-498

  Chang, Suyi ^a   Borensztajn, Jayme ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Albumin; Alcohol; Ethyl ester; Fatty acid; Macrophage

Indexed keywords

ALCOHOL; BOVINE SERUM ALBUMIN; CARBON 14; FATTY ACID ESTER; OLEIC ACID ETHYL ESTER; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ALCOHOL METABOLISM; ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL TRANSPORT; CONTROLLED STUDY; FREEZE DRYING; HYDROPHOBICITY; LUNG ALVEOLUS MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; RAT; SOLUBILIZATION;

ALBUMINS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CELLS, CULTURED; ETHANOL; FATTY ACIDS; KINETICS; MACROPHAGES, ALVEOLAR; OLEIC ACIDS; OXIDATION-REDUCTION; PROTEIN BINDING; RATS; SOLUBILITY; WATER;

EID: 0033521722     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0005-2760(98)00155-6     Document Type: Article

References (18)

1. E. Rubin, J.L. Farber, Environmental and nutritional pathology, in E. Rubin, J.L. Farber (Eds.), Pathology, J.B. Lippincott, Philadelphia, PA, 1994, pp. 296-300.
2. Lieber C.S. Alcohol and the liver: 1994 update. Gastroenterology. 106:1994;1085-1105.
3. Lange L.G. Mechanism of fatty acid ethyl ester formation and biological significance. Ann. NY Acad. Sci. 625:1991;802-805.
4. Laposata E.A., Lange L.G. Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science. 231:1986;497-499.
5. Laposata M. Fatty acid ethyl esters: short-term and long-term serum markers of ethanol intake. Clin. Chem. 43:1997;1527-1534.
6. Bird D.A., Szczepiorkowski Z.M., Trace V.C., Laposata M. Low-density lipoprotein reconstituted with fatty acid ethyl esters as a physiological vehicle for ethyl ester delivery to intact cells. Alcohol. Clin. Exp. Res. 19:1995;1265-1270.
7. Szczepiorkowski Z.M., Dickersin G.R., Laposata M. Fatty acid ethyl esters decrease human hepatoblastoma cell proliferation and protein synthesis. Gastroenterology. 108:1995;515-522.
8. Werner J., Laposata M., Fernandez-del Castillo C., Saghir M., Iozzo R.V., Lewandrowski K.B., Warshaw A.L. Pancreatic injury in rats induced by fatty acid ethyl ester, a nonoxidative metabolite of alcohol. Gastroenterology. 113:1997;286-294.
9. Spector A.A. Fatty acid ethyl esters: insight or intoxication? Gastroenterology. 108:1995;605-607.
10. Doyle K.M., Bird D.A., al-Salihi S., Hallaq Y., Cluette-Brown J.E., Goss K.A., Laposata M. Fatty acid ethyl esters are present in human serum after ethanol ingestion. J. Lipid Res. 35:1994;428-437.
11. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. 37:1959;911-915.
12. Bird D.A., Laposata M., Hamilton J.A. Binding of ethyl oleate to low density lipoprotein, phospholipid vesicles, and albumin: a 13C NMR study. J. Lipid Res. 37:1996;1449-1458.
13. Kuhl W.E., Spector A.A. Uptake of long-chain fatty acid methyl esters by mammalian cells. J. Lipid Res. 11:1970;458-465.
14. Vorum H., Fisker K., Honore B. Palmitate and stearate binding to human serum albumin. Determination of relative binding constants. J. Peptide Res. 49:1997;347-354.
15. Chang W., Waltenbaugh C., Borensztajn J. Fatty acid ethyl ester synthesis by the isolated perfused rat heart. Metabolism. 46:1997;926-929.
16. Bagasara O., Howeedy A., Kajdacsy-Balla A. Macrophage function in chronic experimental alcoholism. I. Modulation of surface receptors and phagocytosis. Immunology. 65:1988;405-409.
17. D'Souza N.B., Nelson S., Summer W.R., Deaciuc I.V. Alcohol modulates alveolar macrophage tumor necrosis factor-α, superoxide anion, and nitric oxide secretion in the rat. Alcohol. Clin. Exp. Res. 20:1996;156-163.
18. Laposata E.A., Harrison E.H., Hedberg E.B. Synthesis and degradation of fatty acid ethyl esters by cultured hepatoma cells exposed to ethanol. J. Biol. Chem. 265:1990;9688-9693.