A stereospecific, intermolecular biaryl-coupling approach to korupensamine A en route to the michellamines

Angewandte Chemie - International Edition

Volumn 38, Issue 23, 1999, Pages 3530-3533

  Lipshutz, Bruce H ^a   Keith, John M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Atropisomerism; Biaryls; Korupensarnines; Michellamines; Tetrahydroisoquinolines

Indexed keywords

ANTIVIRUS AGENT; MICHELLAMINE B; PALLADIUM; TETRAHYDROISOQUINOLINE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CHIRALITY; DIASTEREOISOMER; DRUG STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS; MOLECULAR INTERACTION; NONHUMAN; STEREOCHEMISTRY; STEREOSPECIFICITY;

EID: 0033521225     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(19991203)38:23<3530::AID-ANIE3530>3.0.CO;2-W     Document Type: Article

References (38)

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38. [1d] it is appreciated that structural changes with such tetrahydroisoquinolines can alter the observed CD spectra, thereby leading to erroneous assignments. In the case of derivatives 16, it is apparent that alterations at the C-3 methyl group do not impact, let alone overshadow, the significant bias imposed in each by the axially chiral, nonracemic, biaryl nuclei.