Discontinuation of anticytomegalovirus therapy in patients with HIV infection and cytomegalovirus retinitis

JAMA

Volumn 282, Issue 17, 1999, Pages 1633-1637

  Whitcup, Scott M ^a   Fortin, Eric ^a   Lindblad, Anne S ^d   Griffiths, Paul ^f   Metcalf, Julia A ^b   Robinson, Michael R ^a   Manischewitz, Jody ^e   Baird, Barbara ^c   Perry, Cheryl ^a   Kidd, I Michael ^f   Vrabec, Tamara ^g   Davey, Richard T ^b   Falloon, Judith ^b   Walker, Robert E ^b   Kovacs, Joseph A ^c   Lane, H Clifford ^b   Nussenblatt, Robert B ^a   Smith, Janine ^a   Masur, Henry ^c   Polis, Michael A ^b  

^a NATIONAL EYE INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d EMMES CORPORATION   (United States)

^e CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^f ROYAL FREE HOSPITAL   (United Kingdom)

^g WILLS EYE HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; ANTIVIRUS AGENT; CIDOFOVIR; DIDANOSINE; FOSCARNET; GANCICLOVIR; INDINAVIR; LAMIVUDINE; NELFINAVIR; NEVIRAPINE; RITONAVIR; SAQUINAVIR; STAVUDINE; ZALCITABINE; ZIDOVUDINE;

ADULT; ARTICLE; BLOOD CULTURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MALE; MORBIDITY; MORTALITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RETINITIS; URINE CULTURE; UVEITIS; VIRUS DETECTION; VIRUS LOAD; VISUAL IMPAIRMENT;

EID: 0033520676     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.282.17.1633     Document Type: Article

References (28)

1. Freeman WR, Lerner CW, Mines JA, et al. A prospective study of the ophthalmologic findings in the acquired immunodeficiency syndrome. Am J Ophthalmol. 1984;97:133-142.
2. Studies of Ocular Complications of AIDS Research Group, in collaboration with the AIDS Clinical Trials Group. Mortality in patients with the acquired Immunodeficiency syndrome treated with either foscarnet or ganciclovir for cytomegalovirus retinitis N Engl J Med. 1992;326:213-220.
3. Jacobson MA, O'Donnell JJ, Porteous D, Brodie HR, Feigal D, Mills J. Retinal and gastrointestinal disease due to cytomegalovirus in patients with the acquired immune deficiency syndrome: prevalence, natural history, and response to ganciclovir therapy. QJM. 1988; 67:473-486.
4. Whitcup SM, Fortin E, Nussenblatt RB, Polis MA, Muccioli C, Belfort RJ. Therapeutic effect of combination antiretroviral therapy on cytomegalovirus retinitis. JAMA. 1997;277:1519-1520.
5. + counts. Ophthalmology. 1998;105:1259-1264.
6. Whitcup SM, Cunningham ETJ, Polis MA, Fortin E. Spontaneous and sustained resolution of CMV retinitis in patients receiving highly active antiretroviral therapy. Br J Ophthalmol. 1998;82:846.
7. Reed JB, Schwab IR, Gordon J, Morse LS. Regression of cytomegalovirus retinitis associated with protease inhibitor treatment in patients with AIDS. Am J Ophthalmol. 1997;124:199-205.
8. Macdonald JC, Torriani FJ, Morse LS, Karavellas MP, Reed JB, Freeman WR. Lack of reactivation of cytomegalovirus (CMV) retinitis after stopping maintenance therapy in AIDS patients with sustained elevations in CD4 T cells in response to highly active antiretroviral therapy. J Infect Dis. 1998;177:1182-1187.
9. Tural C, Romeu J, Sirera G, et al. Long-lasting remission of cytomegalovirus retinitis without maintenance therapy in human immunodeficiency virus-infected patients. J Infect Dis. 1998;177:1080-1083.
10. Jabs DA, Bolton SG, Dunn JP, Palestine AG. Discontinuing anticytomegalovirus therapy in patients with immune reconstitution after combination antiretroviral therapy. Am J Ophthalmol. 1998;126:817-822.
11. Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Morb Mortal Wkly Rep. 1992;41:1-19.
12. Ferris FL III, Kasoff A, Bresnick GH, Bailey I, New visual acuity charts for clinical research. Am J Ophthalmol. 1982;94:91-96.
13. Kidd IM, Fox JC, Pillay D, Charman H, Griffiths PD, Emery VC. Provision of prognostic information in immunocompromised patients by routine application of the polymerase chain reaction for cytomegalovirus. Transplantation. 1993;56:867-871.
14. Bowen EF, Sabin CA, Wilson P, et al. Cytomegalovirus (CMV) viraemia detected by polymerase chain reaction identifies a group of HIV-positive patients at high risk of CMV disease. AIDS. 1997;11:889-893.
15. Feinberg MB, Carpenter C, Fauci AS, et al. Report of the NIH Panel to Define Principles of Therapy of HIV Infection. Ann Intern Med. 1998;128:1057-1078.
16. Jabs DA, Bartlett JG. AIDS and ophthalmology: a period of transition. Am J Ophthalmol. 1997;124: 227-233.
17. Palestine AG, Rodrigues MM, Macher AM, et al. Ophthalmic involvement in acquired immunodeficiency syndrome. Ophthalmology. 1984;91:1092-1099.
18. Zegans ME, Walton RC, Holland GN, O'Donnell JJ, Jacobson MA, Margolis TP. Transient vitreous inflammatory reactions associated with combination antiretroviral therapy in patients with AIDS and cytomegalovirus retinitis. Am J Ophthalmol. 1998;125: 292-300.
19. Karavellas MP, Lowder CY, Macdonald JC, Avila CP, Freeman WR. Immune recovery vitritis associated with inactive cytomegalovirus retinitis: a new syndrome. Arch Ophthalmol. 1998;116:169-175.
20. Weinberg DV, Moorthy RS. Cystoid macular edema due to cytomegalovirus in a patient with acquired immunodeficiency virus. Retina. 1996;16:343-344.
21. Jacobson MA, Zegans M, Parvan PR, et al. Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy. Lancet. 1997;349:1443-1445.
22. Karavellas MP, Plummet DJ, Macdonald JC, et al. Incidence of immune recovery vitritis in cytomegalovirus retinitis patients following institution of successful highly active antiretroviral therapy. J Infect Dis. 1999;179:697-700.
23. The Studies of Ocular Complications of AIDS Research Group in Collaboration with the AIDS Clinical Trials Group. Rhegmatogenous retinal detachment in patients with cytomegalovirus retinitis: the Foscamet-Ganciclovir Cytomegalovirus Retinitis Trial. Am J Ophthalmol. 1997;121:61-70.
24. + T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nat Med. 1997;3:533-540.
25. Martin DF, Parks DJ, Mellow SD, et al. Treatment of cytomegalovirus retinitis with an intraocular sustained-release ganciclovir implant: a randomized, controlled clinical trial. Arch Ophthalmol. 1994;112: 1531-1539.
26. Studies of Ocular Complications of AIDS Research Group in Collaboration with the AIDS Clinical Trials Group. Parenteral cidofovir for cytomegalovirus retinitis in patients with AIDS: the HPMPC Peripheral Cytomegalovirus Retinitis Trial: a randomized, controlled trial. Ann Intern Med. 1997;126:264-274.
27. Lalezari JP, Stagg RJ, Kuppermann BD, et al. Intravenous cidofovir for peripheral cytomegalovirus retinitis in patients with AIDS: a randomized, controlled trial. Ann Intern Med. 1997;126:257-263.
28. Musch DC, Martin DF, Gordon JF, Davis MD, Kupperman DB. Treatment of cytomegalovirus retinitis with a sustained-release ganciclovir implant. N Engl J Med. 1997;337:83-90.