Reaction of achiral titanium Z-enolates with chiral α-silyloxy aldehydes

Tetrahedron Letters

Volumn 40, Issue 27, 1999, Pages 5079-5082

  Esteve, Cristina ^a   Ferreró, Mònica ^a   Romea, Pedro ^a   Urpí, Fèlix ^a   Vilarrasa, Jaume ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Aldol reactions; Diastereoselection; Stereoelectronic effects

Indexed keywords

FORMALDEHYDE; TITANIUM DERIVATIVE; TITANIUM ENOLATE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; MOLECULAR INTERACTION; MOLECULAR STABILITY; STEREOCHEMISTRY;

EID: 0033516716     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00986-7     Document Type: Article

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13. 2)CHO; the syn Felkin compound was identified as the major aldol, but a loss of diastereoselectivity is observed as the size of R increases; however, the other stereoisomers have not been characterized and no further explanations have been provided.
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15. All new compounds show spectroscopic and analytical data consistent with the assigned structures.