Stereospecific synthesis of 7-deoxy-6-hydroxy paclitaxel

Tetrahedron Letters

Volumn 40, Issue 27, 1999, Pages 4943-4946

  Wittman, Mark D ^a   Alstadt, Thomas J ^a   Kadow, John F ^a   Vyas, Dolatrai M ^a   Johnson, Kathy ^a   Fairchild, Craig ^a   Long, Byron ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Deoxygenation; Germanium compounds; Taxoids; Thiocarbonates

Indexed keywords

7 DEOXY 6 HYDROXY PACLITAXEL; PACLITAXEL DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG USE; STEREOCHEMISTRY;

EID: 0033516617     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00864-3     Document Type: Article

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13. 0.01was determined for each analog and expressed as a ratio relative to paclitaxel (compound 5=1.0; compound 8=1.1).
14. 50 for compounds 5 (7.0 nM) and 8 (17.6 nM) were determined against HCT-116, a human colon tumor cell line sensitive to paclitaxel (1.7 nM).