Neurokinin-1 receptors and spinal cord control of blood pressure in spontaneously hypertensive rats

Brain Research

Volumn 815, Issue 1, 1999, Pages 116-120

  Solomon, Samuel G ^a   Llewellyn Smith, Ida J ^c   Minson, Jane B ^c   Arnolda, Leonard F ^c   Chalmers, John P ^a   Pilowsky, Paul M ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

^c NONE

Author keywords

Hypertension; Substance P; Sympathetic preganglionic neurons

Indexed keywords

2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; 5 AMINOVALERYLSUBSTANCE P [7-11][9 PROLINE 10 (N METHYLLEUCINE)]; NEUROKININ 1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DEPRESSOR RESPONSE; DOSE RESPONSE; HYPERTENSION; INTERMETHOD COMPARISON; INTRACISTERNAL DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MEAN ARTERIAL PRESSURE; MOLECULAR DYNAMICS; NONHUMAN; PATHOPHYSIOLOGY; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SPINAL CORD; STRAIN DIFFERENCE; THORACIC SPINAL CORD;

ANALGESICS; ANIMALS; BLOOD PRESSURE; HEART RATE; HYPERTENSION; INDOLES; INJECTIONS, SPINAL; NEURONS; PEPTIDE FRAGMENTS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, NEUROKININ-1; SPINAL CORD; SUBSTANCE P; SYMPATHETIC NERVOUS SYSTEM;

EID: 0033514004     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01107-X     Document Type: Article

References (22)

1. Barber R.P., Vaughn J.E., Slemmon J.R., Salvaterra P.M., Roberts E., Leeman S.E. The origin, distribution and synaptic relationships of substance P axons in rat spinal cord. J. Comp. Neurol. 184:1979;331-352.
2. Borkowski K.R. Effect of adrenal demedullation and adrenaline on hypertension development and vascular reactivity in young spontaneously hypertensive rats. J. Auton. Pharmacol. 11:1991;1-14.
3. Cammack C., Logan S.D. Excitation of rat sympathetic preganglionic neurones by selective activation of the NK1 receptor. J. Auton. Nerv. Syst. 57:1996;87-92.
4. Couture R., Hasséssian H., Gupta A. Studies on the cardiovascular effects produced by the spinal action of substance P in the rat. J. Card. Pharmacol. 11:1988;270-283.
5. Dampney R.A.L. The subretrofacial vasomotor nucleus: anatomical, chemical and pharmacological properties and role in cardiovascular regulation. Prog. Neurobiol. 42:1994;197-227.
6. Dun N.J., Mo N. In vitro effects of substance P on neonatal rat sympathetic preganglionic neurones. J. Physiol. (Lond.). 399:1988;321-333.
7. Euler U.S., Gaddum J.H. An unidentified depressor substance in certain tissue extracts. J. Physiol. (Lond.). 72:1931;74-87.
8. Hagan R.M., Ireland S.J., Jordan C.C., Beresford I.J.M., Deal M.J., Ward P. Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: new tools for investigating neurokinin function. Neuropeptides. 19:1991;127-135.
9. Hasséssian H., Couture R. Cardiovascular responses induced by intrathecal substance P in the conscious freely moving rat. J. Card. Pharmacol. 13:1989;594-602.
10. Llewellyn-Smith I.J., Martin C.L., Minson J.B., Pilowsky P.M., Arnolda L.F., Basbaum A.I., Chalmers J.P. Neurokinin-1 receptor-immunoreactive sympathetic preganglionic neurons: target specificity and ultrastructure. Neuroscience. 77:1997;1137-1149.
11. Loewy A.D., Sawyer W.B. Substance P antagonist inhibits vasomotor responses elicited from ventral medulla in rat. Brain Res. 245:1982;379-383.
12. Meini S., Patacchini R., Lecci A., Poulos C., Rovero P., Maggi C.A. GR 73,632 and [Glu(Obzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder. Neuropeptides. 28:1995;99-106.
13. Minson J.B., Arnolda L.F., Llewellyn-Smith I.J., Pilowsky P.M., Chalmers J.P. Altered c-fos in rostral medulla and spinal cord of spontaneously hypertensive rats. Hypertension. 27:1996;433-441.
14. Miyagawa M., Chida K., Kawamura H., Takasu T. Effects of chemical stimulation and lesion of the rostral ventrolateral medulla in spontaneously hypertensive rats. Neurosci. Lett. 132:1991;1-4.
15. Nevin K., Zhuo H., Helke C.J. Neurokinin A coexists with substance P and serotonin in ventral medullary spinally projecting neurons of the rat. Peptides. 15:1994;1003-1011.
16. Pilowsky P.M., Llewellyn-Smith I.J., Lipski J., Chalmers J.P. Substance P immunoreactive boutons form synapses with feline sympathetic preganglionic neurons: an intracellular and electron microscope study. J. Comp. Neurol. 320:1992;121-135.
17. Riphagen C.L., Bauce L., Veale W.L., Pittman Q.J. The effects of intrathecal administration of arginine-vasopressin and substance P on blood pressure and adrenal secretion of epinephrine in rats. J. Auton. Nerv. Syst. 16:1986;91-99.
18. Sasek C.A., Wessendorf M.W., Helke C.J. Evidence for co-existence of thyrotropin-releasing hormone, substance P and serotonin in ventral medullary neurons that project to the intermediolateral cell column in the rat. Neuroscience. 35:1990;105-119.
19. Schramm L.P., Chornoboy E.S. Sympathetic activity in spontaneously hypertensive rats after spinal transection. Am. J. Physiol. 243:1982;R506-R511.
20. Takano Y., Martin J.E., Leeman S.E., Loewy A.D. Substance P immunoreactivity released from rat spinal cord after kainic acid excitation of the ventral medulla oblongata: a correlation with increases in blood pressure. Brain Res. 291:1984;168-172.
21. Takano Y., Sawyer W.B., Loewy A.D. Substance P mechanisms of the spinal cord related to vasomotor tone in the spontaneously hypertensive rat. Brain Res. 334:1985;105-116.
22. Togashi H., Yoshioka M., Minami M., Shimamura K., Saito H., Kitada C., Fujino M. Effect of Substance P antagonist spantide on adrenal sympathetic nerve activity in rats. Jap. J. Pharmacol. 43:1987;253-261.