Indomethacin and Corticosteroids: An Additive Constrictive Effect on the Fetal Ductus Arteriosus

American Journal of Perinatology

Volumn , Issue , 1999, Pages 379-384

  Levy, Roni ^a   Ben Arie, Alon ^a   Milman, Dora ^a   Or, Yuval ^a   Hagay, Zion ^a   Matitiau, Abraham ^a  

^a HEBREW UNIVERSITY   (Israel)

Author keywords

Corticosteroids; ductus arteriosus; indomethacin

Indexed keywords

BETAMETHASONE; CORTICOSTEROID; INDOMETACIN;

ARTICLE; CLINICAL ARTICLE; DISEASE SEVERITY; DRUG POTENCY; DRUG POTENTIATION; DUCTUS ARTERIOSUS OBLITERATION; HEART FUNCTION; HUMAN; NEWBORN; PRIORITY JOURNAL; TRICUSPID VALVE REGURGITATION;

ADRENAL CORTEX HORMONES; ANALYSIS OF VARIANCE; BLOOD FLOW VELOCITY; CHILD, PRESCHOOL; CONSTRICTION, PATHOLOGIC; DRUG THERAPY, COMBINATION; DUCTUS ARTERIOSUS; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; FOLLOW-UP STUDIES; HUMANS; INDOMETHACIN; INFANT; INFANT, NEWBORN; MALE; OBSTETRIC LABOR, PREMATURE; PREGNANCY; REFERENCE VALUES; TOCOLYTIC AGENTS; ULTRASONOGRAPHY, PRENATAL; UTERINE CONTRACTION;

EID: 0033511717     PISSN: 07351631     EISSN: 10988785     Source Type: Journal    
DOI: 10.1055/s-1999-6814     Document Type: Article

References (20)

1. Zuckerman H, Reiss U, Rubinstein I. Inhibition of premature labor with indomethacin. Obstet Gynecol 1974; 44: 787-792
2. Kierse MJ, Grant A, King JF. Preterm labor. Effective care in pregnancy and childbirth. Oxford: Oxford University Press; 1989: 694-745
3. Moise KJ, Huhta JC, Sharif DS, Ou CN, Kirshon B, Wasserstrum N. Indomethacin in treatment of premature labor: Effects on the fetal ductus arteriosus. N Engl J Med 1988; 319: 327-331
4. Wassertrum N, Huhta JC, Mari G, Sharit DS, Willis R, Neal NK. Betamethasone and the human fetal ductus arteriosus. Obstet Gynecol 1989; 74: 897-900
5. Azarcit-Benist A, Benefia L, Matias A, DeCrepy A, Madelenat P. Constriction of the fetal ductus arteriosus during prenatal betamethasone therapy. Obstet Gynecol 1995; 85: 874-876
6. National Institutes of Health Consensus Development Panel on the effect of corticosteroids for fetal maturation in perinatal outcomes. JAMA 1995; 273: 413-418
7. Csaba IF, Solyoc E, Ertl T. Relationship of maternal treatment with indomethacin to persistence of fetal circulation syndrome. J Pediatr 1978; 92: 484-488
8. Norton ME, Merrill J, Cooper BA. Neonatal complications after the administration of indomethacin for preterm labor. N Engl J Med 1993; 329: 1602-1607
9. Nomma K, Takao A. Increased constriction of the ductus arteriosus with combined administration of indomethacin and betamethasone in fetal rats. Pediatr Res 1989; 25: 69-75
10. Clyman RI, Mauray F, Romon C, Rudolph AM, Heyman M. Glucocorticoids alter the sensitivity of the lamb ductus arteriosus to prostaglandin E2. J Pediatr 1981; 98: 126-128
11. Smith WL, Garavito RM, DeWitt DL. Prostaglandin endoperoxide H synthases (cyclooxygenase) 1 and 2. J Biol Chem 1996; 271: 33157-33160
12. Ballard PI. Glucosteroids differentiation. In: Baxter JD, Rousseu GG, eds. Glucosteroidal Hormone Action. Heidelberg: Springer-Verlag; 1979; 493-515
13. Higby K, Xenakis E, Pauerstein C. Do tocolytic agents stop preterm labor? A critical and comprehensive review of efficacy and safety. Am J Obstet Gynecol 1993; 168: 1247-1259
14. Morales WJ, Smith SG, Angel JL, O'Brien WF, Knuppel RA. Efficacy and safety of indomethacin vs ritodrin in the management of preterm labor: A randomized study. Obstet Gynecol 1989; 74: 567-572
15. Morales WJ, Madhav H. Efficacy and safety of indomethacin compared to magnesium sulfate in the management of preterm labor: A randomized study. Am J Obstet Gynecol 1993; 169: 97-102
16. Tan B, Panter K, Hannah M. Indomethacin for the acute tocolysis of preterm labor: A meta-analysis of RCTs. Am J Obstet Gynecol 1996; 174: 466
17. Eronen M, Pesonen E, Kurki T, Ylikorkala O, Hallman M. Effect of indomethacin and B sympathomimetics on the treatment of premature labor. Am J Obstet Gynecol 1991; 164: 141-146
18. Moise KJ. Effect of advancing gestational age on the frequency of fetal ductal constriction in association with maternal indomethacin use. Am J Obstet Gynecol 1993; 168: 1350-1353
19. Respondec M, Weil SR, Huhta JC. Fetal echocardiography during indomethacin treatment. Ultrasound Obstet Gynecol 1995; 5: 86-89
20. Vermillion ST, Scardo JA, Lashus AG, Wiles HB. The effect of indomethacin tocolysis on fetal ductus arteriosus constriction with advancing gestational age. Am J Obstet Gynecol 1997; 177: 256-261