First-line treatment of metastatic breast cancer with mitoxantrone, vinorelbine, and carboplatin

American Journal of Clinical Oncology: Cancer Clinical Trials

Volumn 22, Issue 6, 1999, Pages 568-572

  Kakolyris, Stelios ^a   Kourousis, Charalambos ^a   Koukourakis, Michael ^a   Androulakis, Nikos ^a   Vamvakas, Lambros ^a   Agelaki, Sophia ^a   Hatzidaki, Dora ^a   Samonis, George ^a   Tsiftsis, Dimitrios ^a   Georgoulias, Vassilis ^a  

^a UNIVERSITY HOSPITAL OF HERAKLION   (Greece)

Author keywords

Carboplatin; Metastatic breast cancer; Mitoxantrone; Vinorelbine

Indexed keywords

CARBOPLATIN; MITOXANTRONE; NAVELBINE;

ADULT; ANEMIA; ARTICLE; BREAST CANCER; BREAST METASTASIS; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; DRUG TOLERANCE; FEMALE; HUMAN; NAUSEA; NEUTROPENIA; PHASE 2 CLINICAL TRIAL; SURVIVAL RATE; THROMBOCYTOPENIA; TUMOR GROWTH; VOMITING;

ADULT; AGED; ALOPECIA; ANEMIA; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CARBOPLATIN; CONFIDENCE INTERVALS; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MIDDLE AGED; MITOXANTRONE; NEUTROPENIA; PARESTHESIA; REMISSION INDUCTION; SOFT TISSUE NEOPLASMS; SURVIVAL RATE; THROMBOCYTOPENIA; VINBLASTINE;

EID: 0033509483     PISSN: 02773732     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000421-199912000-00006     Document Type: Article

References (24)

1. Wingo PA, Tong T, Bolden S. Cancer Stat 1995;45:8-30.
2. Potier P. The synthesis of navelbine. Prototype of a new series of vinblastine derivatives. Semin Oncol 1989;16(suppl 4):2-4.
3. Paintrand MR, Pignot I. Navelbine: an ultrastructure study of its effects. J Electron Microsc 1983;32:115-12.
4. Binet S, Chaineau E, Fellows A, et al. Immunofluorescence study of the action of navelbine, vincristine and vinblastine on mitotic and axonal microtubules. Int J Cancer 1990;46:262-6.
5. Fumoleau P, Delgado FM, Delozier T, et al. Phase II trial of weekly intravenous vinorelbine in first line advanced breast cancer chemotherapy. J Clin Oncol 1993;11:1245-52.
6. Garcia-Conde J, Lluch A, Martin M, et al. Phase II trial of weekly IV vinorelbine in first line advanced breast cancer chemotherapy. Ann Oncol 1994;5:854-7.
7. Gasparini G, Caffo O, Barni S, et al. Vinorelbine is an active anti-proliferative agent in pretreated advanced breast cancer patients: a phase II study. J Clin Oncol 1994;12:2094-101.
8. Degardin M, Bonneterre J, Hecquet B, et al. Vinorelbine (Navelbine) as a salvage treatment for advanced breast cancer. Ann Oncol 1994;5:423-6.
9. Spielman M, Dorval T, Turpin F, et al. Phase II trial of vinorelbine/ doxorubicin as first line therapy of advanced breast cancer. J Clin Oncol 1994;12:1764-70.
10. Hochster H, Vogel C, Blumenreich M, et al. A multicenter phase II study of navelbine and doxorubicin as first line chemotherapy of metastatic breast cancer. Proc Am Soc Clin Oncol 1994;13:A203.
11. Wilson KS, Paterson AHG. First line mitoxantrone chemotherapy for advanced breast cancer. Cancer Treat Rep 1986;70:1021-2.
12. Leonard RCF, Cornbleet MA, Kaye SB, et al. Mitoxantrone versus doxorubicin in combination chemotherapy for advanced carcinoma of the breast. J Clin Oncol 1987;5:1056-63.
13. Neidhart JA, Gochnour D, Roach R, et al. A comparison of mitoxantrone and doxorubicin in breast cancer. J Clin Oncol 1986;4:672-7.
14. Ferrero JM, Wendung JL, Hoch M, et al. Mitoxantrone-vinorelbine as first line therapy in metastatic breast cancer. Bull Cancer 1995;82:202-7.
15. Vogel CL. Combination chemotherapy with vinorelbine and mitoxantrone for metastatic breast cancer: a review. Semin Oncol 1995;22(suppl 5):61-5.
16. Muggia FM. Overview of carboplatin: replacing, complementing and extending the therapeutic horizons of cis-platin. Semin Oncol 1989;16(suppl 5):7-13.
17. Kolaric K, Vukas D. Carboplatin activity in untreated metastatic breast cancer - a phase II trial. Cancer Chemother Pharmacol 1991;27:409-12.
18. Martin M, Diaz-Rubio E, Casado A, et al. Carboplatin: an active drug in metastatic breast cancer. J Clin Oncol 1992;10:433-7.
19. Iaffaioli RV, Tortoriello A, Facchini G, et al. A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer. Br J Cancer 1995;72:1256-8.
20. Hayward JL, Carbonne PP, Heuson JC, et al. Assessment of response to therapy in advanced breast cancer. Cancer 1977;9: 1289-94.
21. World Health Organisation. Handbook for reporting results of cancer treatment. Geneva: WHO Offset Publication, no 48, 1979.
22. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Star Assoc 1958;53:457-81.
23. Smith IE, Henderson IC. New treatment for breast cancer. Semin Oncol 1996;33:506-28.
24. Llombart-Cussac A, Pivot X, Rhor-Alvarado A, et al. First line vinorelbine-mitoxantrone combination in metastatic breast cancer patients relapsing after an adjuvant anthracycline regimen: results of a phase II study. Oncology 1998;55:384-90.