Increased expression of multidrug resistance of P-glycoprotein on Th1 cells correlates with drug resistance in rheumatoid arthritis

Arthritis and Rheumatism

Volumn 42, Issue 9, 1999, Pages 2014-2015

  Yudoh, Kazuo ^a   Matsuno, Hiroaki ^a   Nakazawa, Fujio ^a   Yonezawa, Tamon ^a   Kimura, Tomoatsu ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRHEUMATIC AGENT; BUCILLAMINE; GAMMA INTERFERON; GLYCOPROTEIN P; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN; PREDNISOLONE; SALAZOSULFAPYRIDINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG EFFICACY; FEMALE; GENE OVEREXPRESSION; HUMAN; INTERFERON PRODUCTION; MALE; MULTIDRUG RESISTANCE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; TH1 CELL;

ADULT; ARTHRITIS, RHEUMATOID; DRUG RESISTANCE, MULTIPLE; FEMALE; HUMANS; MALE; MIDDLE AGED; P-GLYCOPROTEIN; TH1 CELLS;

EID: 0033508491     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199909)42:9<2014::AID-ANR32>3.0.CO;2-R     Document Type: Article

References (7)

1. Scanlon K, Ishida H, Kashani-Sahet M. Ribozyme-mediated reversal of the multidrug-resistant phenotype. Proc Natl Acad Sci U S A 1994;91:11123-7.
2. Maillefert JF, Maynadie M, Tebib JG, Aho S, Walker P, Chatard C, et al. Expression of the multidrug resistance glycoprotein 170 in the peripheral blood lymphocytes of rheumatoid arthritis patients: the percentage of lymphocytes expressing glycoprotein 170 is increased in patients treated with prednisolone. Br J Rheumatol 1996;35: 430-5.
3. Dolhain RJEM, van der Heiden AN, ter Haar NT, Breedveld FC, Miltenburg AMM. Shift toward T lymphocytes with a T helper 1 cytokine-secretion profile in the joints of patients with rheumatoid arthritis. Arthritis Rheum 1996;39:1961-9.
4. Bonecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A, et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2. J Exp Med 1998;187:129-34,
5. Felson DT, Anderson JJ, Boers M, Bombardier C, Chernoff M, Fried B, et al. The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. Arthritis Rheum 1993;36:729-40.
6. Flier JS, Underhill LH. Multiple drug resistance in human cancer. N Engl J Med 1987;316:1388-93.
7. Rodenhuis S, Kremer JM, Bertino JR. Increase of dihydrofolate reductase in peripheral blood lymphocytes of rheumatoid arthritis patients treated with low-dose oral methotrexate. Arthritis Rheum 1987;30:369-74.