Ingestion of chilli pepper (Capsicum annuum) reduces salicylate bioavailability after oral aspirin administration in the rat

Canadian Journal of Physiology and Pharmacology

Volumn 77, Issue 6, 1999, Pages 441-446

  Cruz, Leticia ^a   Castañeda Hernández, Gilberto ^b   Navarrete, Andrés ^c  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

Aspirin; Bioavailability; Capsaicin; Capsicum annuum; Drug food interaction

Indexed keywords

ACETYLSALICYLIC ACID; SALICYLIC ACID;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; FOOD DRUG INTERACTION; MALE; NONHUMAN; PEPPER; PRIORITY JOURNAL; RAT;

EID: 0033505779     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/cjpp-77-6-441     Document Type: Article

References (23)

1. Alvares, A.P., Anderson, K.E., Conney, A.H., and Kappas, A. 1976. Interactions between nutritional factors and drug biotransformation in man. Proc. Natl. Acad. Sci. U.S.A. 73: 2501-2504.
2. Bailey, D.G., Arnold, J.M.O., and Spence, D. 1994. Grapefruit juice and drugs. How significant is the interaction? Clin. Pharmacokinet. 33:140-145.
3. Bromm, B., Rundshagen, I., and Scharein, E. 1991. Central analgesic effects of acetylsalicylic in healthy men. Arzneim. Forsch. 41: 1123-1129.
4. Buck, S.H., and Burks, T.F. 1983. Capsaicin: hot new pharmacological tools. Trends Pharmacol. Sci. 4: 84-87.
5. Campbell, T.C., and Hayes, J.R. 1974. Role of nutrition in the drug-metabolizing enzyme system. Pharmacol. Rev. 26: 171-197.
6. Canadian Council on Animal Care. 1989. Ethics of animal investigation. Canadian Council on Animal Care, Ottawa, Ont.
7. Castañeda-Hernández, G., Castillo-Méndez, M.S., López-Muñoz, F.J., Granados-Soto, V., and Flores-Murrierta, F.J. 1994. Potentiation by caffeine of aspirin in the pain-induced functional impairment model in the rat. Can. J. Physiol. Pharmacol. 72: 1127-1131.
8. Dromgoole, S.H., and Furst, E.D. 1992. Salicylates. In Applied pharmacokinetics: principles of therapeutic drug monitoring. 3rd ed. Edited by E.W. Evans, J.J. Schentag, and J.W. Jusko. Applied Therapeutics Inc., Vancouver, Wash. pp. 32.1-32.34.
9. Hatakeyama, Y., Matsuo, M., Tomoi, M., Ohtsuka, M., and Shimomura, K. 1995. Luminal dilution caused by certain mild irritants and capsaicin contributes to their gastric mucosal protection. Am. J. Physiol. G200-G206.
10. Hatori, A., Shigematsu, A., and Tsuya, A. 1984. The metabolism of aspirin in rats: localization, absorption, distribution and excretion. Eur. J. Drug Metab. Pharmacokinet. 9: 205-214.
11. Insel, P.A. 1996. Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout. In Goodman and Gilman's: The pharmacologic basis of therapeutics. 9th ed. Edited by J.G. Hardman, L.E. Iwamoto, K., Takei, M., and Watanabe. J. 1982. Gastrointestinal and hepatic first-pass metabolism of aspirin in rats. J. Pharm. Pharmacol. 34: 176-180.
12. Insel, P.A. 1996. Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout. In Goodman and Gilman's: The pharmacologic basis of therapeutics. 9th ed. Edited by J.G. Hardman, L.E. Iwamoto, K., Takei, M., and Watanabe. J. 1982. Gastrointestinal and hepatic first-pass metabolism of aspirin in rats. J. Pharm. Pharmacol. 34: 176-180.
13. Limbird, P.B. Molinoff, R.W. Ruddon, and A. Goodman Gilman. McGraw-Hill, New York. pp. 617-657.
14. Limlomwongse, L., Chaitauchawong, C., and Tongyai, S. 1979. Effect of capsaicin on gastric acid secretion and mucosal blood flow in the rat. J. Nutr. 109: 773-777.
15. López-Carrillo, I., Hernández, A.M., and Dubrow, R. 1994. Chilli pepper consumption and gastric cancer in Mexico: a case-control study. Am. J. Epidemiol. 139: 263-271.
16. Pantuck, E.J., Hsiao, K.C., Kuntzman, R., and Conney, A.H. 1975. Intestinal metabolism of phenacetin in the rat: effect of charcoal-broiled beef and rat chow. Science (Washington, D.C.), 187: 744-746.
17. Patrono, C. 1994. Aspirin as an antiplatelet drug. New Engl. J. Med. 330: 1287-1294.
18. Sauter, R., Steinijans, V.W., Diletti, E., Böhm, A., and Schulz, H.U. 1992. Presentation of results from bioequivalence studies. Int. J. Clin. Pharmacol. Ther. Toxicol. 30: 233-256.
19. Steinijans, V.W., and Diletti, E. 1983. Statistical analysis of bioavailability studies: parametric and non-parametric confidence intervals. Eur. J. Clin. Pharmacol. 24: 127-136.
20. Takeuchi, K., Niidia, H., Matsumoto, J., Ueshima, K., and Okabe, S. 1991. Gastric motility in capsaicin-induced cytoprotection in the rat stomach. Jpn. J. Pharmacol. 55: 147-155.
21. Torres-López, J.E., López-Muñoz, F.J., Castañeda-Hernández, G., Flores-Murrieta, F.J., and Granados-Soto, V. 1997. Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of diclofenac in the rat. J. Pharmacol. Exp. Ther. 282: 685-690.
22. Uduphille, M. 1993. The effect of capsaicin on the small intestine absorption of glucose and alanine in the rat. Indian J. Physiol. Pharmacol. 37: 59-62.
23. Wanwimolruk, S., Nyika, S., Kepple, M., Ferry, D.G., and Clak, C.R. 1993. Effects of capsaicin on the pharmacokinetics of antipyrine, theophylline and quinine in rats. J. Pharm. Pharmacol. 45: 618-621.