Evidence for neural regulation of inflammatory synovial cell functions by secreting calcitonin gene-related peptide and vasoactive intestinal peptide in patients with rheumatoid arthritis

Arthritis and Rheumatism

Volumn 42, Issue 11, 1999, Pages 2418-2429

  Takeba, Yuko ^a   Suzuki, Noboru ^a   Kaneko, Atsushi ^b   Asai, Tomiaki ^b   Sakane, Tsuyoshi ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOKINE; NEUROPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE;

ADULT; AGED; ARTICLE; CELL FUNCTION; CELL PROLIFERATION; CLINICAL ARTICLE; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN TISSUE; INFLAMMATION; MALE; PATHOPHYSIOLOGY; PERIPHERAL NERVE; PRIORITY JOURNAL; RADIORECEPTOR ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE;

ADULT; AGED; ARTHRITIS, RHEUMATOID; BIOLOGICAL TRANSPORT; CALCITONIN GENE-RELATED PEPTIDE; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYTOKINES; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MIDDLE AGED; NERVOUS SYSTEM; PHOSPHORYLATION; SYNOVIAL MEMBRANE; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0033504271     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199911)42:11<2418::AID-ANR21>3.0.CO;2-7     Document Type: Article

References (65)

1. Harris ED Jr. Rheumatoid arthritis: pathophysiology and implications for therapy. N Engl J Med 1990;322:1277-89.
2. Cash JM, Klippel JH. Second-line drug therapy for rheumatoid arthritis. N Engl J Med 1994;330:1368-75.
3. Panayi GS, Lanchbury JS, Kingsley OH. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum 1992;35:729-35.
4. Zvaifler NJ, Firestein GS. Pannus and pannocytes: alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum 1994;37:783-9.
5. Dayer J-M, de Rochemonteix B, Burrus B, Demczuk S, Dinarello CA. Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells. J Clin Invest 1986;77:645-8.
6. Meyer FA, Yaron I, Yaron M. Synergistic, additive, and antagonistic effects of interleukin-1β, tumor necrosis factor a, and γ-interferon on prostaglandin E, hyaluronic acid, and collagenase production by cultured synovial fibroblasts. Arthritis Rheum 1990; 33:1518-25.
7. Woessner JF Jr. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 1991;5:2145-54.
8. Butler DM, Piccoli DS, Hart PH, Hamilton JA. Stimulation of human synovial fibroblast DNA synthesis by recombinant human cytokines. J Rheumatol 1988;15:1463-70.
9. Hškfelt T, Kellerth JO, Nilsson G, Pernow B. Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons. Brain Res 1975; 100:235-52.
10. Kimball ES. Substance P, cytokines, and arthritis. Ann N Y Acad Sci 1990;594:293-308.
11. Wilder RL. Neuroendocrine-immune system interactions and autoimmunity. Annu Rev Immunol 1995;13:307-38.
12. Lotz M, Carson DA, Vaughan JH. Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis. Science 1987;235:893-5.
13. Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 1982; 298:240-4.
14. Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I. Calcitonin gene-related peptide is a potent vasodilator. Nature 1985;313:54-6.
15. Fox FE, Kubin M, Cassin M, Niu Z, Hosoi J, Torii H, et al. Calcitonin gene-related peptide inhibits proliferation and antigen presentation by human peripheral blood mononuclear cells: effects on B7, interleukin 10, and interleukin 12. J Invest Dermatol 1997;108:43-8.
16. Wang F, Millet I, Bottomly K, Vignery A. Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes. J Biol Chem 1992;267:21052-7.
17. Takami H, Ito K. Calcitonin gene-related peptide as a tumor marker for medullary thyroid carcinoma. Int Surg 1992;77:181-5.
18. Hillyard CJ, Oscier DG, Foa R, Catovsky D, Goldman JM. Immunoreactive calcitonin in leukaemia. BMJ 1979;2:1392-3.
19. Fanciullacci M, Alessandri M, Figini M, Geppetti P, Michelacci S. Increase in plasma calcitonin gene-related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack. Pain 1995;60:119-23.
20. Arnalich F, de Miguel E, Perez-Ayala C, Martinez M, Vazquez JJ, Gijon-Banos J, et al. Neuropeptides and interleukin-6 in human joint inflammation: relationship between intraarticular substance P and interleukin-6 concentrations. Neurosci Lett 1994;170:251-4.
21. Lygren I, Ostensen M, Burhol PG, Husby G. Gastrointestinal peptides in serum and synovial fluid from patients with inflammatory joint disease. Ann Rheum Dis 1986;45:637-40.
22. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
23. Aiyar N, Baker E, Martin J, Patel A, Stadel JM, Willette RN, et al. Differential calcitonin gene-related peptide (CGRP) and amylin binding sites in nucleus accumbens and lung: potential models for studying CGRP/amylin receptor subtypes. J Neurochem 1995;65: 1131-8.
24. 17] VIP. Am J Physiol 1986;250:G553-7.
25. Wakisaka S, Suzuki N, Saito N, Ochi T, Sakane T. Possible correction of abnormal rheumatoid arthritis synovial cell function by jun D transfection in vitro. Arthritis Rheum 1998;41:470-81.
26. Takeba Y, Suzuki N, Takeno M, Asai T, Tsuboi S, Hoshino T, et al. Modulation of synovial cell function by somatostatin in patients with rheumatoid arthritis. Arthritis Rheum 1997;40:2128-38.
27. Nagafuchi H, Suzuki N, Kaneko A, Asai T, Sakane T. Prolactin locally produced by synovium infiltrating T lymphocytes induces excessive synovial cell functions in patients with rheumatoid arthritis. J Rheumatol. In press.
28. Mochizuki M, Suzuki N, Takeno M, Nagafuchi H, Harada T, Kaneoka H, et al. Fine antigen specificity of human γδ T cell lines (Vγ9+) established by repetitive stimulation with a serotype (KTH-1) of a gram-positive bacterium, Streptococcus sanguis. Eur J Immunol 1994;24:1536-43.
29. Chong C, Bost KL, Clements JD. Differential production of interleukin-12 mRNA by murine macrophages in response to viable or killed Salmonella spp. Infect Immun 1996;64:1154-60.
30. Kincy-Cain T, Bost KL. Substance P-induced IL-12 production by murine macrophages. J Immunol 1997;158:2334-9.
31. Kobayashi T, Hattori S, Nagai Y, Sakuraoka K, Nishikawa T. Secretion of different types of gelatinases from cultured human keratinocytes. J Dermatol 1997;24:213-6.
32. Heussen C, Dowdle EB. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal Biochem 1980;102:196-202.
33. Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, et al. A cDNA encoding the calcitonin gene-related peptide type 1 receptor. J Biol Chem 1996;271:11325-9.
34. Svoboda M, Tastenoy M, van Rampelbergh J, Goossens J-F, De Neef P, Waelbroeck M, et al. Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts. Biochem Biophys Res Commun 1994;205:1617-24.
35. Adamou JE, Aiyar N, van Horn S, Elshourbagy NA. Cloning and functional characterization of the human vasoactive intestinal peptide (VIP) -2 receptor. Biochem Biophys Res Commun 1995; 209:385-92.
36. Park SK, Olson TA, Ercal N, Summers M, O'Dorisio MS. Characterization of vasoactive intestinal peptide receptors on human megakaryocytes and platelets. Blood 1996;87:4629-35.
37. Hislop AA, Boels PJ, Deutsch J, Polak JM, Haworth SG. Developmental changes in binding sites and reactivity for CGRP and VIP in porcine pulmonary arteries. Peptides 1998;19:703-14.
38. Scatchard G. The attractions of proteins for small molecules and ions. Ann N Y Acad Sci 1949;51:660-72.
39. Habener JF, Meyer TE, Yun Y, Waeber G, Hoeffler JP. Characterization of a cAMP-regulated enhancer-binding protein. Metabolism 1990;39 Suppl 2:13-6.
40. Symes AJ, Rao MS, Lewis SE, Landis SC, Hyman SE, Fink JS. Ciliary neurotrophic factor coordinately activates transcription of neuropeptide genes in a neuroblastoma cell line. Proc Natl Acad Sci U S A 1993;90:572-6.
41. Asahina A, Moro O, Hosoi J, Lerner EA, Xu S, Takashima A, et al. Specific induction of cAMP in Langerhans cells by calcitonin gene-related peptide: relevance to functional effects. Proc Natl Acad Sci U S A 1995;92:8323-7.
42. Pereira da Silva JA, Carmo-Fonseca M. Peptide containing nerves in human synovium: immunohistochemical evidence for decreased innervation in rheumatoid arthritis. J Rheumatol 1990;17:1592-9.
43. Grönblad M, Konttinen YT, Korkala O, Liesi P, Hukkanen M, Polak JM. Neuropeptides in synovium of patients with rheumatoid arthritis and osteoarthritis. J Rheumatol 1988;15:1807-10.
44. Levine JD, Moskowitz MA, Basbaum AI. The contribution of neurogenic inflammation in experimental arthritis. J Immunol 1985;135:843-7.
45. Brain SD, Cambridge H, Hughes SR, Wilsoncroft P. Evidence that calcitonin gene-related peptide contributes to inflammation in the skin and joint. Ann N Y Acad Sci 1992;657:412-9.
46. Wiesenfeld-Hallin Z, Hokfelt T, Lundberg JM, Forssmann WG, Reinecke M, Tschopp FA, et al. Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons in spinal cord and interact in spinal behavioral responses of the rat. Neurosci Lett 1984;52:199-204.
47. Buck SH, Walsh JH, Yamamura HI, Burks TF. Neuropeptides in sensory neurons. Life Sci 1982;30:1857-66.
48. Konttinen YT, Kemppinen P, Segerberg M, Hukkanen M, Rees R, Santavirta S, et al. Peripheral and spinal neural mechanisms in arthritis, with particular reference to treatment of inflammation and pain. Arthritis Rheum 1994;37:965-82.
49. Ahmed M, Bjurholm A, Schultzberg M, Theodorsson E, Kreicbergs A. Increased levels of substance P and calcitonin gene-related peptide in rat adjuvant arthritis: a combined immunohistochemical and radioimmunoassay analysis. Arthritis Rheum 1995;38:699-709.
50. Levine JD, Dardick SJ, Roizen MF, Helms C, Basbaum AI. Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis. J Neurosci 1986;6:3423-9.
51. Ahmed M, Srinivasan GR, Theodorsson E, Schultzberg M, Kreicbergs A. Effects of surgical denervation on substance P and calcitonin gene-related peptide in adjuvant arthritis. Peptides 1995;16:569-79.
52. D'Souza SM, Maclntyre I, Girgis SI, Mundy GR. Human synthetic calcitonin gene-related peptide inhibits bone resorption in vitro. Endocrinology 1986;119:58-61.
53. Jorgensen C, Sany J. Modulation of the immune response by the neuro-endocrine axis in rheumatoid arthritis. Clin Exp Rheumatol 1994;12:435-41.
54. Sakuta H, Inaba K, Muramatsu S. Calcitonin gene-related peptide enhances cytokine-induced IL-6 production by fibroblasts. Cell Immunol 1995;165:20-5.
55. Konttinen YT, Rees R, Hukkanen M, Grönblad M, Tolvanen E, Gibson SJ, et al. Nerves in inflammatory synovium: immunohistochemical observations on the adjuvant arthritic rat model. J Rheumatol 1990;17:1586-91.
56. Walsh DA, Mapp PI, Wharton J, Polak JM, Blake DR. Neuropeptide degrading enzymes in normal and inflamed human synovium. Am J Pathol 1993;142:1610-21.
57. Imai S, Rauvala H, Konttinen YT, Tokunaga T, Maeda T, Hukuda S, et al. Efferent targets of osseous CGRP-immunoreactive nerve fiber before and after bone destruction in adjuvant arthritic rat: an ultramorphological study on their terminal-target relations. J Bone Miner Res 1997;12:1018-27.
58. Imai S, Tokunaga Y, Konttinen YT, Maeda T, Hukuda S, Santavirta S. Ultrastructure of the synovial sensory peptidergic fibers is distinctively altered in different phases of adjuvant induced arthritis in rats: ultramorphological characterization combined with morphometric and immunohistochemical study for substance P, calcitonin gene related peptide, and protein gene product 9.5. J Rheumatol 1997;24:2177-87.
59. Stanisz AM, Scicchitano R, Bienenstock J. The role of vasoactive intestinal peptide and other neuropeptides in the regulation of the immune response in vitro and in vivo. Ann N Y Acad Sci 1988;527:478-85.
60. Ottaway CA. Vasoactive intestinal peptide as a modulator of lymphocyte and immune function. Ann N Y Acad Sci 1988;527: 486-500.
61. Umeda Y. Inhibition of immune responses by calcitonin gene-related peptide. Ann N Y Acad Sci 1992;657:552-4.
62. Lorenz JJ, Furdon PJ, Taylor JD, Verghese MW, Chandra G, Kost TA, et al. A cyclic adenosine 3′,5′-monophosphate signal is required for the induction of IL-1β by TNF-α in human monocytes. J Immunol 1995;155:836-44.
63. Tanabe T, Otani H, Zeng X-T, Mishima K, Ogawa R, Inagaki C. Inhibitory effects of calcitonin gene-related peptide on substance-P-induced superoxide production in human neutrophils. Eur J Pharmacol 1996;314:175-83.
64. Hashimoto K, Lipsky PE. Immunosuppression by the disease modifying antirheumatic drug bucillamine: inhibition of human T lymphocyte function by bucillamine and its metabolites. J Rheumatol 1993;20:953-7.
65. Takeba Y, Suzuki N, Wakisaka S, Nagafuchi H, Mihara S, Kaneko A, et al. Effects of actarit on synovial cell functions in patients with rheumatoid arthritis. J Rheumatol 1999;26:25-33.