Human proinsulin gene-transfected Chinese hamster ovary cells secrete immunoreactive insulin

In Vivo

Volumn 13, Issue 6, 1999, Pages 535-540

  Sato, Yoshitoshi ^a   Nio, Yoshinori ^a   Omori, Hiroshi ^a   Inoue, Yasushi ^a   Hirahara, Noriyuki ^a   Sasaki, Susumu ^a   Tamura, Katsuhiro ^a  

^a SHIMANE UNIVERSITY   (Japan)

Author keywords

Artificial pancreas; Diabetes mellitus; Gene transfection; Insulin; Transkaryotic cell

Indexed keywords

IMMUNOREACTIVE INSULIN; PROINSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL PANCREAS; CHO CELL; DIABETES MELLITUS; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC TRANSFECTION; GLUCOSE TOLERANCE TEST; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; MOUSE; NONHUMAN; NORMAL HUMAN; PANCREAS ISLET BETA CELL; PANCREAS SECRETION; PANCREAS TRANSPLANTATION;

EID: 0033504139     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. International Pancreas Transplant Registry Newsletter 7: 11, 1994.
2. Wamock GL, Kneteman NM, Ryan EA, Ravinovitch A, Rajotte RV: Long-term follow-up after transplantation of insulin-producing pancreatic islets into patients with type I (insulin-dependent) diabetes mellitus. Diabetologia 35: 89-95, 1992.
3. International Islet Transplant Registry 4: 4-19, 1994.
4. Socci C, Falqui L, Davalli AM, Ricordi C, Braghi S, Bertuzi F, Maffi P, Secchi A, Gavazi F, Freschi M, Magistretti P, Socci S, Di Carlo V, Poza G: Fresh human islet transplantation to replace pancreatic endocrine function in type 1 diabetic patients. Report of six cases. Acta Diabetol Lat 28: 151-157, 1991.
5. Gores PF, Najarian JS, Stephanian E, Lloveras JJ, Kelley SL, Sutherland DE: Insulin independence in type I diabetes after transplantation of unpurified islets from single donor with 15-deoxyspergualin. Lancet 341: 19-21, 1993.
6. Platt JL, Vercellotti GM, Delmasso AT, Matas AJ, Bolman RM, Najarian JS, Bach FH: Transplantation of discordant xenografts: a review of progress. Immunol Today 11: 450-456, 1990.
7. Paul LC: Mechanisms of humoral xenograft rejection. In: Xenotransplantation, the transplantation of organs and tissues between species (Cooper DK, Kemp E, Reemtsma K, WhiteDJ, eds). Berlin Springer, 1991, pp47-67.
8. Shichiri M, Kawamori R, Yamasaki Y, Hakui N, Abe H: Wearable artificial endocrine pancreas with needle-type glucose sensor. Lancet 20: 1129-1131, 1982.
9. Shichiri M, Kawasaki R, Hakui N, Yamasaki Y, Abe H: Closed-loop glycemic control with a wearable artificial endocrine pancreas. Diabetes 33: 1200-1202, 1984.
10. Hashiguchi Y, Uemura T, Sakakida M, KaJiwara K, Nishio K, Shichiri M: Development of a miniaturized glucose monitoring system by combining a needle-type glucose sensor with microdialysis sampling method. Diabetes Care 17: 387-396, 1994.
11. Selden RF, Skoskiewicz MJ, Russel PS, Goodman HM: Regulation of insulin-gene expression. Implication for gene therapy. N Eng J Med 317: 1067-1076, 1987.
12. Huges SD, Johnson JH, Quaade C, Newgard CB: Newgard. Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells. Proc Natl Acad Sci 89: 688-692, 1992.
13. Hughes SD, Quaade C, Johnson JH, Feber S, Newgard CB: Transfection of AtT-20ins cells with CLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. J Biol Chem 268: 15205-15212, 1993.
14. Ferber S, Beltrandel RH, Johnson JH, Noel RJ, Cassidy LE, Clark S, Becker TC, Hughes SD, Newgard CB: GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. J Biol Chem 269: 11523-11529, 1994.
15. Schnedl WJ, Hohmeier HE, Newgard CB: Insulin producing cells as therapy in diabetes mellitus (review). Naturwissenschaften 83: 1-5, 1996.
16. Bell GI, Swain WF, Pictet R, Cordell B, Goodman HM, Rutter WJ: Nucleotide sequence of a cDNA clone encoding human preproinsulin. Nature 282: 525-527, 1979.
17. Bell GI, Pictet R, Rutter WJ, Cordell B, Tischer E, Goodman HM: Sequence of the human insulin gene. Nature 294: 26-32, 1980.
18. Ovejera AA, Houchens DP, Baker AD: Chemotherapy of human tumor xenografts in genetically athymic mice. Ann Clin Lab Sci 8: 50-56, 1978.
19. Orci L, Thorens B, Ravazzola M, Lodish HF: Localization of the pancreatic beta cell glucose transporter to specific plasma membrane domains. Science 245: 295-297, 1989.
20. Chen L, Alam T, Johnson JH, Hughes S, Newgard CB, Unger RH: Regulation of ß-cell glucose transporter gene expression. Proc Natl Acad Sci USA 87: 4988-4092, 1990.