Identification of two distinct subsets of long-term nonprogressors with divergent viral activity by stromal-derived factor 1 chemokine gene polymorphism analysis

Journal of Infectious Diseases

Volumn 180, Issue 2, 1999, Pages 285-289

  Balotta, Claudia ^a   Bagnarelli, Patrizia ^b   Corvasce, Stefano ^a   Mazzucchelli, Renata ^a   Colombo, M Chiara ^a   Papagno, Laura ^a   Santambrogio, Sara ^a   Ridolfo, Anna Lisa ^a   Violin, Michela ^a   Berlusconi, Alberto ^a   Velleca, Rossella ^a   Facchi, Guido ^a   Moroni, Mauro ^a   Clementi, Massimo ^c   Galli, Massimo ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; LIGAND;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ALLELE; ARTICLE; CELL COUNT; DNA POLYMORPHISM; FEMALE; GENETIC ANALYSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RNA TRANSLATION; VIREMIA; VIRUS REPLICATION;

ADULT; AGED; CHEMOKINES, CXC; FEMALE; GIANT CELLS; HIV INFECTIONS; HIV LONG-TERM SURVIVORS; HIV-1; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRUS REPLICATION;

EID: 0033503122     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314864     Document Type: Article

References (26)

1. 1. D'Souza MP, Harden VA, Chemokines and HIV-1 second receptors. Confluence of two fields generates optimism in AIDS researcyh. Nat Med 1996;2:1293-1300.
2. 2. Dean M, Carrington M, Winkler C, et al. Genetic restriction of HIV-1 infection and progression to AIDS by a detection allelc of the CKR5 structural gene. Science 1996;273;1856-62.
3. 3. Smith MW, Dean M, Carrington M, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Science 1997;277:959-64.
4. 4. Quillent C, Oberlin E, Braun J, et al. HIV-1 resistance phenotype conferred by combination of two separate inherited mutations of CCR5 gene. Lancet 1998;351:14-8.
5. 5. Huang Y, Paxton WA, Wolinsky SM, et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat Med 1996;2:1240 3.
6. 6. Zimmerman PA, Buckler-White A, Alkhatib G, et al. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. Mol Med 1997;3:23-36.
7. 7. Michael NL, Louie LG, Rohrbaugh AL, et al. The role of CCK5 and CCR2 polymorphisms in HIV-1 transmission and disease progression. Nat Med 1997;3:1160-2.
8. 8. Oberlin E, Amara A, Bachelerie F, et al. The CXC cheniokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line adapted HIV-1. Nature 1996;382:833-5.
9. 9. Winkler C, Modi W, Smith MW, et al. Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. Science 1998;279:389 93.
10. 10. van RiJ RP, Broersen S, Goudsmit J, Coutinho RA, Schuitemaker H. The role of a SDF-1 chemokine gene variant in the clinical course of HIV-1 infection. AIDS 1998;12:F85-90.
11. 11. Mummidi S, Ahuja S, Gonzalez E, et al. Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression. Nat Med 1998;4:786-93.
12. 12. Magierowska M, Theodorou I, Debré P, et al. Combined genotypes of CTR5. CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals. Blood 1999;93:936-41.
13. 13. Hendel H, Hénon N, Lebuanec H, et al. Distinctive effects of CCR5, CCR2, and SDF1 genetic polymorphisms in AIDS progression. J Acquir Immune Defic Syndr Hum Retrovirol 1998;19:381-6.
14. 14. Rizzuto CD, Wyatt R, Hernandez-Ramos N, et al. A conserved HIV gp120 envelope glycoprotein structure involved in chemokine receptor binding. Science 1998;280:1949-53.
15. 15. Hollinger FB, Bremer JW, Myers LE, Gold JWM, McQuay L. The NTH/ NIAID/DAIDS/ACTG Virology Laboratories. Standardization of sensitive human immunodeficiency virus coculturc procedures and establishment of a multicenter quality assurance program for the AIDS Clinical Trials Group. J Clin Microbiol 1992;30:1787-94.
16. 16. Balotta C, Viganò A, Riva C, et al. HIV-1 phenotype correlates with the stage of infection in vertically infected children. AIDS Res Hum Retro-viruses 1996;12:1247-53.
17. 17. Bagnarelli P, Valenza A, Menzo S, et al. Dynamics and modulation of human immunodeficiency virus type 1 transcripts in vitro and in vivo. J Virol 1996;70:7603-13.
18. 18. Bagnarelli P, Valenza A, Menzo S, et al. Dynamics of molecular parameters of human immunodeficiency virus type I activity in vivo. J Virol 1994; 68:2495-502.
19. 19. Mellors JW, Kingsley LA, Rinaldo CR Jr, et al. Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 1995;122:573-9.
20. 20. Clerici M, Balotta C, Meroni L, et al. Type I cytokine production and low prevalence of viral isolation correlate with long-term nonprogression in HIV infection. AIDS Res Hum Retroviruses 1996;12:1053-61.
21. 21. Cao Y. Qin L, Zhang L, Sfrit J, Ho DD. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type I infection. N Engl J Med 1995;332:201-8.
22. 22. Bleul CC, Parolin C, Clark-Lewis I, et al. The lymphocyte chemoaltractant SDF-1 is a Iigand for LESTR/fusin and blocks HIV-1 entry. Nature 1996;382:829-32.
23. 23. Amara A, Le Gall S, Schwartz O, et al. HIV coreceptor downregulation as antiviral principle: SDF-1α-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J Exp Med 1997;186:139-46.
24. 24. Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A. Springer TA. A highly efficacious lymphocyte chemoattractant, stromal cell derived factor 1 (SDF-1). J Exp Med 1996;184:1101-9.
25. 25. Schuitemaker H, Koot M, Kootstra NA, et al. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell tropic virus population. J Virol 1992;66:1354-60.
26. 26. Berger EA, Doms RW, Fenyo EM, et al. A new classification of HIV-1 [letter]. Nature 1998;391:240.