Early empiric antifungal therapy of infections in neutropenic patients comparing fluconazole with amphotericin B/flucytosine

Mycoses, Supplement

Volumn 42, Issue 2, 1999, Pages 101-104

  Silling, Gerda ^a   Fegeler, W ^b   Roos, N ^b   Essink, M ^b   Buchner T ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b NONE

Author keywords

Amphotericin B; Antimycotic chemotherapy; Empiric therapy; Fluconazole; Flucytosine; Neuropenia

Indexed keywords

AMPHOTERICIN B; FLUCONAZOLE; FLUCYTOSINE;

ADOLESCENT; ADULT; AGED; ANTIFUNGAL ACTIVITY; CHILL; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FEVER; HUMAN; MAJOR CLINICAL STUDY; MALE; MYCOSIS; NEUTROPENIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TOXICITY;

EID: 0033501801     PISSN: 09437312     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1439-0507.1999.tb00023.x     Document Type: Conference Paper

References (18)

1. Armstrong, D., Young, L. S., Meyer, R. D., Blevins, A. H. (1971) Infectious complications of neoplastic disease. Med. Clin. North. Am. 55, 729-745.
2. Degregorio, M. W., Lee, W. M. F., Linker, C. A., Jacobs, R. A., Ries, C. A. (1982) Fungal infections in patients with acute leukemia. Am. J. Med. 73, 543-548.
3. Robertson, M. F., Larson, R. A. (1988) Recurrent fungal pneumonias in patients with acute nonlymphocytic leukemia undergoing multiple courses of intensive chemotherapy. Am. J. Med. 84, 233-239.
4. Mirsky, H. S., Cuttner, J. (1972) Fungal infections in acute leukemia. Cancer 50, 348-352.
5. Bodey, G. P. (1986) Infection in cancer patients - a continuing association. Am. J. Med. 81, 11-26.
6. Brown, A. E. (1984) Neutropenia, fever, and infection. Am. J. Med. 76, 421-428.
7. Maschmeyer, G., Link, H., Hiddemann, W., Meyer, P., Helmerking, M., Eisenmann, F., et al. (1994) Empirische antimikrobielle Therapie bei neutropenischen Patienten, Ergebnisse einer multizentrischen Studie der Arbeitsgruppe Infektionen in der Haematologie der Paul-Ehrlich-Gesellschaft. Med. Klin. 89, 114-123.
8. EORTC International Antimicrobial Therapy Cooperative Group. (1989). Empirical antifungal therapy in febrile granulocytopenic patients. Am. J. Med. 86, 668-672.
9. Pizzo, P. A., Robichaud, K. J., Gil, F. A., Witebsky, F. G. (1982) Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia. Am. J. Med. 72, 101-111.
10. Sugar, A. M. (1990) Empiric treatment of fungal infections in the neutropenic host. Arch. Intern. Med. 150, 2258-2261.
11. Bodey, G. P. (1986) Fungal infections and fever of unknown origin in neutropenic patients. Am. J. Med. 80 (suppl 5C), 112-119.
12. Cornely, O. A., Hiddemann, W., Link, H., Maschmeyer, G., Cilaß, B., Buchheidt, D., et al. For the Study Grouup of the PEG (1997) Interventioneal antimicrobial therapy in febrile neutropenic patietns - Paul-Ehrlich-Society for chemotherapy (PEG) Study H. Ann. Hematol. 74 (Suppl I), A 51, Abstract 204.
13. Anaissie, E. J., Darouiche, R., Abi-Said, D., Uzun, O., Mera, J., Genry, L. O., et al. (1996) Management of invasive candidal infections: Results of a prospective, randomized, multicenter study of fluconazole versus amphotericin B and review of the literature. Clin. Infect. Dis. 23, 964-972.
14. Rex, J. H., Bennett, J. E., Sugar, A. M., Pappas, P. G., van der Horst, G. M., Edwards, J. E., et al. (1994) A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia. Candidemia Study Group and the National Institute. N. Engl. J. Med. 331, 1325-1330.
15. Kujath, P., Lerch, K., Kochendörfer, P., Boos, C. (1993) Comparative study of the efficacy of fluconazole versus amphotericin B/5-flucytosine in surgical patients with systemic mycosis. Infection 21, 376-381.
16. Viscoli, C., Castagnola, E., Vant Lint, M. T., Moroni, C., Garaventa, A., Rossi, M. R., et al. (1996) Fluconazole versus amphotericin B as empirical antifungal therapy of unexplained fever in granulocytopenic cancer patients: a pragmatic, multicentre, prospective and randomised clinical trial. Eur. J. Cancer 32A, 814-820.
17. Malik, I. A., Moid, I., Aziz, Z., Khan, S., Suleman, M. (1998) A randomized comparison of fluconazole with amphotericin B as ermpiric antifungal agents in cancer patients with prolonged fever and neutropenia. Am. J. Med. 105, 479-483.
18. Abele-Horn, M., Kopp, A., Sternberg, U., Ohly, A., Dauber, A., Russwurm, W., et al. (1996) A randomized study comparing fluconazole with amphotericin B/5-flucytosine for the treatment of systemic candida infections in intensive care patients. Infection 24, 426-432.