Adenosine mediates nitric-oxide-independent renal vasodilation by activation of A(2A) receptors

Journal of Hypertension

Volumn 17, Issue 12 SUPPL., 1999, Pages 1987-1993

  Rump, Lars Christian ^a   Jabbari T, Javad ^a   Von Kügelgen, Ivar ^b   Oberhauser, Vitus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

A(2A) receptor; Adenosine; Dilation; EDHF; Endothelium; Nitric oxide; Potassium channels; Rabbit renal arteries

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ACETYLCHOLINE; ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2 RECEPTOR; ENDOTHELIUM DERIVED RELAXING FACTOR; IBERIOTOXIN; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHLORIDE; PURINERGIC RECEPTOR BLOCKING AGENT;

ANIMAL TISSUE; ARTERY DIAMETER; CONFERENCE PAPER; ENZYME INHIBITION; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RENAL ARTERY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASODILATATION;

EID: 0033499091     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199917121-00032     Document Type: Conference Paper

References (26)

1. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, et al. Nomenclature and classification of purinoceptors. Pharmacol Rev 1994; 46:143-156.
2. Holz FG, Steinhausen M. Renovascular effects of adenosine receptor agonists. Ren Physiol 1987; 10:272-282.
3. Weihprecht H, Lorenz JN, Briggs JP, Schnermann J. Vasomotor effects of purinergic agonists in isolated afferent arterioles. Am J Physiol 1992; 263:F1026-F1033.
4. 2 adenosine receptor-mediated relaxation induced by 5′-N-ethylcarboxamido-adenosine and N6-cyclopentyladenosine. J Pharmacol Exp Ther 1994; 270:893-899.
5. 2 receptors in guinea-pig aorta. Eur J Pharmacol 1990; 190:329-335.
6. Inscho EW, Carmines PK, Navar LG. Juxtamedullary afferent arteriolar responses to P1 and P2 purinergic stimulation. Hypertension 1991; 17:1033-1037.
7. Bohmann C, von Kugelgen I, Rump LC. P2-receptor modulation of noradrenergic neurotransmission in rat kidney. Br J Pharmacol 1997, 121:1255-1262.
8. Churchill PC, Bidani AK. Adenosine and renal function. In: Williams M (editor): Adenosine and adenosine receptors. Clifton: Humana Press; 1991:335-380.
9. Marraccini P, Fedele S, Marzilli M, Orsini E, Dukic G, Serasini L, L'Abbate A. Adenosine-induced renal vasoconstriction in man. Cardiovasc Res 1996; 32:949-953.
10. Wierema TK, Postma CT, Houben AJ, Kroon AA, Thien T, Smits P, de Leeuw PW. Adenosine-induced renal vasodilatation is prolonged in renal artery stenosis. J Hypertens 1998; 16:2109-2112.
11. Rump LC, Oberhauser V, von Kügelgen I. Purinoceptors mediate renal vasodilation by nitric oxide dependent and independent mechanisms. Kidney Int 1998; 54:473-481.
12. + is an endothelium-derived hyperpolarizing factor in rat arteries. Nature 1998; 396:269-272.
13. 2A adenosine receptor-mediated dilation of the pressurized renal arcuate artery. Br J Pharmacol 1999; 126:494-500.
14. Bohmann C, Rump LC, Schaible U, von Kügelgen I. Alpha-adrenoceptor modulation of norepinephrine and ATP release in isolated kidneys of spontaneously hypertensive rats. Hypertension 1995; 25:1224-1231.
15. 2A-receptors in rat portal vein. Br J Pharmacol 1998; 123:1732-1740.
16. 2A adenosine receptor antagonist. J Pharmacol Exp Ther 1996, 276:398-404.
17. Lewis CD, Hourani SM, Long CJ, Collis MG. Characterization of adenosine receptors in the rat isolated aorta. Gen Pharmacol 1994; 25:1381-1387.
18. Broadley KJ, Maddock HL. P1-purinoceptor-mediated vasodilatation and vasoconstriction in hypoxia. J Auton Pharmacol 1996; 16:363-366.
19. Randall MD. The involvement of ATP-sensitive potassium channels and adenosine in the regulation of coronary flow in the isolated perfused rat heart. Br J Pharmacol 1995; 116:3068-3074.
20. Kuo L, Chancellor JD. Adenosine potentiates flow-induced dilation of coronary arterioles by activating KATP channels in endothelium. Am J Physiol 1995; 269:H541-H549.
21. + channels. Am J Physiol 1994; 267:H1455-H1460.
22. + channels. Life Sci 1996; 58:2225-2232.
23. Jiang P, Collins C. Inhibition of hypoxia-induced relaxation of rabbit isolated coronary arteries by NG-monomethyl-L-arginine but not glibenclamide. Br J Pharmacol 1994, 111:711-716.
24. + channels mediate dilatation of cerebral arterioles during hypoxia. Circ Res 1994, 74:1005-1008.
25. Vanhoutte PM. Old-timer makes a comeback. Nature 1998, 396: 213, 215-216.
26. 2+ channel by targeting the alpha 1C subunit. Arterioscler Thromb Vase Biol 1999, 19:959-966.