Regulation of chromatin accessibility for V(D)J recombination

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 64, Issue , 1999, Pages 183-189

  Hernandez Munain, G ^a   McMurry, M Taylor ^a   Krangel, M S ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMATIN STRUCTURE; CONFERENCE PAPER; DNA METHYLATION; ENHANCER REGION; GENE ACTIVATION; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; PRIORITY JOURNAL; PROMOTER REGION; ALLELIC EXCLUSION; ARTICLE; CELL LINEAGE; CHROMATIN; CLONAL VARIATION; GENE; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; GERM LINE; HISTONE ACETYLATION; HUMAN; NONHUMAN; POLYMERASE CHAIN REACTION; REGULATOR GENE; TRANSCRIPTION REGULATION; VDJ RECOMBINATION;

T LYMPHOCYTE RECEPTOR;

EID: 0033498713     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.1999.64.183     Document Type: Conference Paper

References (42)

1. Alvarez J.D., Anderson S.J., and Loh D.Y. 1995. V(D)J recombination and allelic exclusion of a TCR β-chain minilocus occurs in the absence of a functional promoter. J. Immunol. 155: 1191.
2. Angelin-Duclos C. and Calame K. 1999. Evidence that immunoglobulin VH-DJ recombination does not require germ line transcription of the recombining variable gene segment. Mol. Cell. Biol. 18: 6253.
3. Blackwood E.M. and Kadonaga J.T. 1998. Going the distance: A current view of enhancer action. Science 281: 60.
4. Bories J.-C., Demengeot J., Davidson L., and Alt F.W. 1996. Gene-targeted deletion and replacement of the T-cell receptor β-chain enhancer: The role of enhancer elements in controlling V(D)J recombination accessibility. Proc. Natl. Acad. Sci. 93: 7871.
5. Bouvier G., Watrin F., Naspetti M., Verthuy C., Naquet P., and Ferrier P. 1996. Deletion of the mouse T-cell receptor β gene enhancer blocks αβ T-cell development. Proc. Natl. Acad. Sci. 93: 7877.
6. Chen J., Young F., Bottaro A., Stewart V., Smith R.K., and Alt F.W. 1993. Mutations of the intronic IgH enhancer and its flanking sequences differentially affect accessibility of the JH locus. EMBO J. 12: 4635.
7. Constantinescu A. and Schlissel M. 1997. Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development. J. Exp. Med. 185: 609.
8. Davie J.R. 1998. Covalent modifications of histones: Expression from chromatin templates. Curr. Opin. Genet. Dev. 8: 173.
9. Durum S.K., Candelais S., Nakajima H., Leonard W.J., Baird A.M., Berg L.J., and Muegge K. 1998. Interleukin 7 receptor control of T cell receptor γ gene rearrangement: Role of receptor-associated chains and locus accessibility. J. Exp. Med. 188: 2233.
10. Fernex C., Capone M., and Ferrier P. 1995. The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate. Mol. Cell. Biol. 15: 3217.
11. Ferradini L., Gu H., de Smet A., Rajewsky K., Reynaud C.-A., and Weill J.-C. 1996. Rearrangement-enhancing element upstream of the mouse immunoglobulin kappa chain J cluster. Science 271: 1416.
12. Gellert M. 1997. Recent advances in understanding V(D)J recombination. Adv. Immunol. 64: 39.
13. Grawunder U., West R.B., and Lieber M.R. 1998. Antigen receptor gene rearrangement. Curr. Opin. Immunol. 10: 172.
14. Hebbes T.R., Clayton A.L., Thorne A.W., and Crane-Robinson C. 1994. Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken β-globin chromosomal domain. EMBO J. 13: 1823.
15. Hempel W.M., Leduc I., Mathieu N., Tripathi R.K., and Ferrier P. 1998a. Accessibility control of V(D)J recombination: Lessons from gene targeting. Adv. Immunol. 69: 309.
16. Hempel W.M., Stanhope-Baker P., Mathieu N., Huang F., Schlisse! M.S., and Ferrier P. 1998b. Enhancer control of V(D)J recombination at the TCRβ locus: Differential effects on DNA cleavage and joining. Genes Dev. 12: 2305.
17. Imhof A., Imbalzano A.N., Ogryzko V.V., Nakatani Y., Wolffe A.P., and Ge H. 1997. Acetylation of general transcription factors by histone acetyltransferases. Curr. Biol. 7: 689.
18. Jenuwein T., Forrester W.C., Qiu R.-G., and Grosschedl R. 1993. The immunoglobulin μ enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation. Genes Dev. 1: 2016.
19. Jenuwein T., Forrester W.C., Fernandez-Herrero L.A., Laible G., Dull M., and Grosschedl R. 1997. Extension of chromatin accessibility by nuclear matrix attachment regions. Nature 385: 269.
20. Jones P.L., Veenstra G.J.C., Wade P.A., Vermaak D., Kass S.U., Landsberger N., Strouboulis J., and Wolffe A.P. 1998. Methylated DNA and MeCP2 recruit histone deacctylase to repress transcription. Nat. Genet. 19: 187.
21. Kuo M.-H., Zhou J., Jambeck P., Churchill M.E.A., and Allis C.D. 1998. Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo. Genes Dev. 12: 627.
22. Kwon J., Imbalzano A.N., Matthews A., and Oettinger M.A. 1998. Accessibility of nucleosomal DNA to V(D)J cleavage is modulated by RSS positioning and HMG1. Mol. Cell 2: 829.
23. Lauzurica P. and Krangel M.S. 1994. Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor δ transgene. J. Exp. Med. 179: 43.
24. McMurry M.T., Hernandez-Munain C., Lauzurica P., and Krangel M.S. 1997. Enhancer control of local accessibility to V(D)J recombinase. Mol. Cell. Biol. 17: 4553.
25. Mostoslavsky R. and Bergman Y. 1997. DNA methylation: Regulation of gene expression and role in the immune system. Biochim. Biophys. Acta 1333: F29.
26. Mostoslavsky R., Singh N., Kirillov A., Pelanda R., Cedar H., Chess A., and Bergman Y. 1998. K chain monoallelic demethylation and the establishment of allelic exclusion. Genes Dev. 12: 1801.
27. Nan X., Ng H.-H., Johnson C.A., Laherty C.D., Turner B.M., Eisenman R.N., and Bird A. 1998. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393: 386.
28. Okada A., Mendelsohn M., and Alt F. 1994. Differential activation of transcription versus recombination of transgenic T cell receptor β variable region gene segments in B and T lineage cells. J. Exp. Med. 180: 261.
29. Parekh B.S. and Maniatis T. 1999. Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-β promoter. Mol. Cell 3: 125.
30. Roth D.B., Zhu C., and Gellert M. 1993. Characterization of broken DNA molecules associated with V(D)J recombination. Proc. Natl. Acad. Sci. 90: 10788.
31. Schatz D.G. 1997. V(D)J recombination moves in vitro. Semin. Immunol. 9: 149.
32. Schlissel M.S. and Stanhope-Baker P. 1997. Accessibility and the developmental regulation of V(D)J recombination. Semin. Iinmunol. 9: 161.
33. Schlissel M., Constantinescu A., Morrow T., Baxter M., and Peng A. 1993. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev. 7: 2520.
34. Sikes M.L., Suarez C.C., and Oltz E.M. 1999. Regulation of V(D)J recombination by transcriptional promoters. Mol. Cell. Biol. 19: 2773.
35. Sleckman B.P., Gorman J.R., and Alt F.W. 1996. Accessibility control of antigen receptor variable region gene assembly: Role of cis-acting elements. Annu. Rev. Iinmunol. 14: 459.
36. Sleckman B.P., Bardon C.G., Ferrini R., Davidson L., and Alt F.W. 1997. Function of the TCRa enhancer in αβ and γδ T cells. Immunity 7: 505.
37. Stanhope-Baker P., Hudson K.M., Shaffer A.L., Constantinescu A., and Schlissel M.S. 1996. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell 85: 887.
38. Strahl K. 1998. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 12: 599.
39. Villey I., Caillol D., Selz F., Ferrier P., and de Villartay J.-P. 1996. Defect in rearrangement of the most 5′ TCR-Jα following targeted deletion of T early α (TEA): Implications for TCRα locus accessibility. Immunity 5: 331.
40. Whitehurst C.E., Chattopadhyay S., and Chen J. 1999. Control of V(D)J recombinational accessibility of the Dβ1 gene segment at the TCRβ locus by a germline promoter. Immunity 10: 313.
41. Wolffe A.P., Wong J., and Pruss D. 1997. Activators and repressors: Making use of chromatin to regulate transcription. Genes Cells 2: 291-302.
42. H gene segments. Cell 40: 271.