Theiler's murine encephalomyelitis virus (TMEV): The role of a small out-of-frame protein in viral persistence and demyelination

Japanese Journal of Infectious Diseases

Volumn 52, Issue 6, 1999, Pages 228-233

  Obuchi, Masatsugu ^a   Ohara, Yoshiro ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS PROTEIN; VIRUS VECTOR;

CARDIOVIRUS; DEMYELINATION; DISEASE MODEL; MACROPHAGE; MULTIPLE SCLEROSIS; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PERSISTENT VIRUS INFECTION; PICORNAVIRUS; POLIOMYELITIS; REVIEW; VIRUS MUTANT; VIRUS STRAIN;

ANIMALS; BRAIN; CARDIOVIRUS INFECTIONS; CELL LINE; CRICETINAE; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, VIRAL; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; KIDNEY; MACROPHAGES; MEMBRANE PROTEINS; MESOCRICETUS; MICE; MULTIPLE SCLEROSIS; POINT MUTATION; POLIOMYELITIS; RODENT DISEASES; THEILOVIRUS; VIRAL PROTEINS; VIRULENCE; VIRUS LATENCY;

EID: 0033497343     PISSN: 13446304     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (44)

1. Ohara, Y. and Roos, R. (1987): The antibody response in Theiler's virus infection: New perspectives on multiple sclerosis, p.156-179. In J. L. Melnick (ed.), Prog. Med. Virol. vol. 34. S. Karger, Basel.
2. Rodriguez, M., Oleszak, E. and Leibowitz, J. (1987): Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus. CRC Critical Rev. Immunol., 7, 325-365.
3. Obuchi, M. and Ohara, Y. (1998): Theiler's murine encephalomyelitis virus and mechanisms of its persistence. Neuropathology, 18, 13-18.
4. Lipton, H. L. (1980): Persistent Theiler's murine encephalomyelitis virus infection in mice depends on plaque size. J. Gen. Virol., 46, 169-177.
5. Roos, R. P., Kong, W. P. and Semler, B. L. (1989): Polyprotein processing of Theiler's murine encephalomyelitis virus. J. Virol., 63, 5344-5353.
6. Kong, W. P. and Roos, R. P. (1991): Alternative translation initiation site in the DA strain of Theiler's murine encephalomyelitis virus. J. Virol., 65, 3395-3399.
7. Pevear, D. C., Calenoff, M., Rozhon, E. and Lipton, H. L. (1987): Analysis of the complete nucleotide sequence of the picornavirus Theiler's murine encephalomyelitis virus indicates that it is closely related to cardioviruses. J. Virol., 61, 1507-1516.
8. Ohara, Y., Stein, S., Fu, J., Stillman, L., Klaman, L. and Roos, R. P. (1988): Molecular cloning and sequence determination of DA strain of Theiler's murine encephalomyelitis viruses. Virology, 164, 245-255.
9. Rueckert, R. R. (1996): Picornaviridae: The viruses and their replication. p 609-654. In B. N. Fields, D. M. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P. Monath, B. Roizman and S. E. Straus (eds.), Fields Virology. Lippincott-Raven Publishers, Philadelphia.
10. Olitsky, P. K. (1945): Certain properties of Theiler's virus, especially in relation to its use as model for poliomyelitis. Proc. Soc. Exp. Biol. Med., 58, 77-81.
11. Tsunoda, I., Kurtz, C. I. B. and Fujinami, R. S. (1997): Apoptosis in acute and chronic central nervous system disease induced by Theiler's murine encephalomyelitis virus. Virology, 228, 388-393.
12. Lipton, H. L. (1975): Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination. Infect. Immun., 11, 1147-1155.
13. Lehrich, J. R., Arnason, B. G. W. and Hochberg, F. H. (1976): Demyelinative myelopathy in mice induced by the DA virus. J. Neurol. Sci., 29, 149-160.
14. Dal Canto, M. C. and Lipton, H. L. (1975): Primary demyelination in Theiler's virus infection. An ultrastructual study. Lab. Invest., 33, 626-637.
15. Friedmann, A. and Lipton, H. L. (1980): Replication of Theiler's murine encephalomyelitis viruses in BHK21 cells: An electron microscopic study. Virology, 101, 389-398.
16. Obuchi, M., Ohara, Y., Takegami, T., Murayama, T., Takada, H. and Iizuka, H. (1997): Theiler's murine encephalomyelitis virus subgroup strain-specific infection in a murine macrophage-like cell line. J. Virol., 71, 729-733.
17. Obuchi, M., Yamamoto, J., Uddin, M. N., Odagiri, T., Iizuka, H. and Ohara, Y. (1999): Theiler's murine encephalomyelitis virus (TMEV) subgroup stain-specific infection in neural and non-neural cell lines. Microbiol. Immunol., 43, 885-892.
18. Rodriguez, M., Leibowitz, J. L. and Lampert, P. W. (1983): Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis. Ann. Neurol., 13, 426-433.
19. Brahic, M., Stroop, W. G. and Baringer, J. R. (1981): Theiler's virus persists in glial cells during demyelinating disease. Cell, 26, 123-128.
20. Ohara, Y., Konno, H., Iwasaki, Y., Yamamoto, T., Terunuma, H. and Suzuki, H. (1990): Cytotropism of Theiler's murine encephalomyelitis viruses in oligodendrocyte-enriched cultures. Arch. Virol., 114, 293-298.
21. Aubert, C., Chamorro, M. and Brahic, M. (1987): Identification of Theiler's virus infected cells in the central nervous system of the mouse during demyelinating disease. Microb. Pathog., 3, 319-326.
22. Dal Canto, M. C. and Lipton, H. L. (1982): Ultrastructural immunohistochemical localization of virus in acute and chronic demyelinating Theiler's virus infection. Am. J. Pathol., 106, 20-29.
23. Clatch, R. J., Miller, S. D., Metzner, R., Dal Canto, M. C. and Lipton, H. L. (1990): Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV). Virology, 176, 244-254.
24. Lipton, H. L., Twaddle, G. and Jelachich, M. L. (1995): The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease. J. Virol., 69, 2525-2533.
25. Levy, M., Aubert, C. and Brahic, M. (1992): Theiler's virus replication in brain macrophages cultured in vitro. J. Virol., 66, 3188-3193.
26. Rossi, C. P., Delcroix, M., Huitinga, I., McAllister, A., Rooijen, N. V., Claassen, E. and Brahic, M. (1997): Role of macrophages during Theiler's virus infection. J. Virol., 71, 3336-3340.
27. Grant, R. A., Filman, D. J., Fujinami, R. S., Icenogle, J. P. and Hogle, J. M. (1992): Three-dimensional structure of Theiler virus. Proc. Natl. Acad. Sci. USA, 89, 2061-2065.
28. Luo, M., He, C., Toth, K. S., Zhang, C. X. and Lipton, H. L. (1992): Three-dimensional structure of Theiler murine encephalomyelitis virus (BeAn strain). Proc. Natl. Acad. Sci. USA, 89, 2409-2413.
29. Pevear, D. C., Borkowski, J., Calenoff, M., Oh, C. K., Ostrowski, B. and Lipton, H. L. (1988): Insights into Theiler's virus neurovirulence based on a genomic comparison of the neurovirulent GDVII and less virulent BeAn strains. Virology, 165, 1-12.
30. Ohara, Y., Senkowski, A., Fu, J., Klaman, L., Goodall, J., Toth, M. and Roos, R. P. (1988): Trypsin-sensitive neutralization site on VP1 of Theiler's murine encephalomyelitis viruses. J. Virol., 62, 3527-3529.
31. Zurbriggen, A., Thomas, C., Yamada, M., Roos, R. P. and Fujinami, R. S. (1991): Direct evidence of a role for amino acid 101 of VP-1 in central nervous system disease in Theiler's murine encephalomyelitis virus infection. J. Virol., 65, 1929-1937.
32. Sato, S., Zhang, L., Kim, J., Jakob, J., Grant, R. A., Wollmann, R. and Roos, R. P. (1996): A neutralization site of DA strain of Theiler's murine encephalomyelitis virus important for disease phenotype. Virology, 226, 327-337.
33. Roos, R. P., Stein, S., Ohara, Y., Fu, J. and Semler, B. L. (1989): Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus. J. Virol., 63, 5492-5496.
34. Tangy, F., McAllister, A. and Brahic, M. (1989): Molecular cloning of the complete genome of strain GDVII of Theiler's virus and production of infectious transcripts. J. Virol., 63, 1101-1106.
35. Kong, W-P., Ghadge, G. D. and Roos, R. P. (1994): Involvement of cardiovirus leader in host cell-restricted virus expression. Proc. Natl. Acad. Sci. USA, 91, 1796-1800.
36. Michiels, T., Jarousse, N. and Brahic, M. (1995): Analysis of the leader and capsid coding regions of persistent and neurovirulent strains of Theiler's virus. Virology, 214, 550-558.
37. Takata, H., Obuchi, M., Yamamoto, J., Odagiri, T., Roos, R. P., Iizuka, H. and Ohara, Y. (1998): L* Protein of the DA strain of Theiler's murine encephalomyelitis virus is important for virus growth in a murine macrophage-like cell line. J. Virol., 72, 4950-4955.
38. Ghadge, G. D., Ma, L., Sato, S., Kim, J. and Roos, R. P. (1998): A protein critical for a Theiler's virus-induced immune system-mediated demyelinating disease has a cell type-specific antiapoptotic effect and a key role in virus persistence. J. Virol., 72, 8605-8612.
39. Ahmed, R., Morrison, L. A. and Knipe, D. M. (1997): Viral persistence. p181-205. In N. Nathanson, R. Ahmed, F. Gonzalez-Scarano, D. E. Griffin, K. V. Holmes, F. A. Murphy and H. L. Robinson (eds.), Viral Pathogenesis. Lippincott-Raven Publishers, Philadelphia.
40. Chen, H. H., Kong, W. P., Zhang, L., Ward, P. L. and Roos, R. P. (1995): A picornaviral protein synthesized out of frame with the polyprotein plays a key role in a virus-induced immune-mediated demyelinating disease. Nature Med., 1, 927-931.
41. Lin, X., Roos, R. P., Pease, L. R., Wettstein, P. and Rodriguez, M. (1999): A Theiler's virus alternatively initiated protein inhibits the generation of H-2K-restricted virus-specific cytotoxicity. J. Immunol., 162, 17-24.
42. Yamasaki, K., Weihl, C. C. and Roos, R. P. (1999): Alternative translation initiation of Theiler's murine encephalomyelitis virus. J. Virol., 73, 8519-8526.
43. Obuchi, M., Odagiri, T., Iizuka, H. and Ohara, Y. (1999): Expression of lymphotoxin gene inserted into Theiler's murine encephalomyelitis virus. Microbiol. Immunol., 43, 83-86.
44. Zhang, L., Sato, S., Kim, J. I. and Roos, R. P. (1995): Theiler's virus as a vector for foreign gene delivery. J. Virol., 69, 3171-3175.